A5100422738- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- COVID-19 Impact on Reproduction
- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Dermatological diseases and infestations
- Maternal and fetal healthcare
- Genetic Syndromes and Imprinting
- Blood groups and transfusion
- Breastfeeding Practices and Influences
- Cancer-related molecular mechanisms research
- Renin-Angiotensin System Studies
- Child Nutrition and Feeding Issues
- Bariatric Surgery and Outcomes
- Endometrial and Cervical Cancer Treatments
- Maternal and Perinatal Health Interventions
- Insect and Pesticide Research
- Fatty Acid Research and Health
- Cervical Cancer and HPV Research
- Global Public Health Policies and Epidemiology
- Scoliosis diagnosis and treatment
Shanxi Medical University
2025
Sir Run Run Shaw Hospital
2023-2025
Zhejiang University
2023-2025
Stomatological Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Zhejiang University of Technology
2023
Capital Medical University
2023
Sichuan Agricultural University
2022
Soochow University
2017-2022
First Affiliated Hospital of Soochow University
2017-2022
To investigate the changes in gut microbiome second trimester of pregnancy associated with later-diagnosed gestational diabetes mellitus (GDM) and their relationship fasting serum levels metabolites, especially glucose.We carried out a case-control study 110 GDM patients 220 healthy pregnant women who provided fecal samples for 16S ribosomal ribonucleic acid sequencing pregnancy.Our results showed that had lower α-diversity was significantly glycemic traits. Principal coordinates analysis...
Using 16S rRNA sequencing analysis, regression analysis and mediation were used to explore whether maternal gestational diabetes mellitus (GDM) changed the function composition of meconium microbiota this explained GDM-induced alterations infant body mass index (BMI). This study showed that gut microbiome dysbiosis induced by GDM might play an important role in increased BMI during first 12 months life.
Abstract Background and Objectives The A weak B is a rare phenotype in the ABO blood group system. Here, we first report novel mutation discovered Chinese woman with an B. Third‐generation sequencing was employed to investigate molecular mechanisms underlying By correctly identifying phenotype, it useful for increasing safety of transfusion. Materials Methods identified by standard serological test polymerase chain reaction sequence‐specific primers (PCR‐SSP). To analyse gene sequence,...
Introduction Mid-gestation is a critical period for the development of nervous system. Exposure to exogenous harmful chemicals during this may lead longterm neurological developmental abnormalities in offspring. Benzo[a]pyrene (B[a]P) commonly occurring neurotoxic environmental pollutant that can pass through placental barrier and blood-brain (BBB), thereby affecting nerve development. Methods To investigate mechanism B[a]P on offspring exposed mid-gestation, pregnant rats were (25 mg/kg)...
Recurrent aphthous ulcer (RAU) is a prevalent oral mucosal disease, affecting around 20% of the global population. It can greatly impair quality life for affected individuals. However, exact etiology RAU remains unknown.
Organophosphate esters (OPEs) are extensively manufactured and used in China. Whether exposure to OPEs during pregnancy increases the risk of gestational diabetes mellitus (GDM) is unknown. Between 2011 2012, a case-control study including 130 67 women with without GDM, respectively, was conducted Hangzhou, The levels 10 maternal serum samples at delivery were quantified, relationships between OPE concentrations GDM investigated. results show that all participants, tri-n-butyl phosphate...
Hypoxia during pregnancy could cause abnormal development and lead to increased risks of vascular diseases in adults. This study determined angiotensin II (AII)-mediated dysfunction offspring middle cerebral arteries (MCA).
BackgroundDengue virus (DENV) infection during pregnancy increases the risk of adverse fetal outcomes, which has become a new clinical challenge. However, underlying mechanism remains unknown.MethodsThe effect DENV-2 on fetuses was investigated using pregnant interferon α/β receptor-deficient (Ifnar1−/−) mice. The histopathological changes in placentas were analyzed by morphological techniques. A mouse inflammation array used to detect cytokine and chemokine profiles serum placenta....
The aim of this study was to investigate the application ultrasonic elastography in diagnosis clinical staging cervical cancer (CC) and its evaluation value treatment effect CC. A total 160 suspected CC patients treated our hospital from September 2016 March 2018 were collected. Transvaginal conventional ultrasound performed on compare results two pathology Radiotherapy used for confirmed as CC75 patients. difference strain ratio (SR) between elastic efficacy compared. sensitivity (94.67%),...
Abstract Human placental vessels (HPVs) play important roles in the exchange of metabolites and oxygen maternal-fetal circulation. Endothelial-derived prostacyclin (prostaglandin I2, PGI2) is a critical endothelial vasodilator body. However, physiological pharmacological functions PGI2 human placenta are still unclear. Human, sheep, rat blood were used this study. Unlike non-placental (non-PVs), synthesis inhibitor tranylcypromine (TCP) did not modify 5-hydroxytryptamine (5-HT)-induced...
Maternal antibodies may partially confer protection to neonates from some viral infections1; however, understanding the nature and durability of perinatal humoral immune responses infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is limited.2 In this study, dynamic changes antibody levels six newborns born mothers corona virus disease-2019 (COVID-19) were investigated.
Background: Placental blood vessels play important roles in maternal-fetal circulation. Although pathologic mechanisms of preeclampsia are unclear, it is known that placental vascular dysfunction could contribute to pregnant hypertension. However, micro-vessel function or at preterm has not been investigated. Methods: Human placentas from normal and preeclamptic pregnancies term were obtained. micro-vessels used for determining tension responses various vasoconstrictors as well intracellular...
Background Antenatal intrauterine fetal hypoxia is a common pregnancy complication that has profound adverse effects on an individual's vascular health later in life. Pulmonary arteries are sensitive to hypoxia, but of antenatal pulmonary vasoreactivities the offspring remain unknown. This study aimed determine and related mechanisms artery functions adult male offspring. Methods Results Pregnant Sprague-Dawley rats were housed normoxic or hypoxic (10.5% O2) chamber from gestation days 10...
Octadecanoic acid-3,4-tetrahydrofuran diester is a compound with acaricidal activity isolated and extracted from neem oil. In this study, series of derivatives were obtained by structural modification octadecanoic diester. The these indicated that introduction benzyloxy substitution at the 2-position furan ring formation benzoate 3,4-position (benzoic acid-2-benzyloxy-3,4-tetrahydrofuran diester) could enhance activity. At concentration 20, 10, 5 mg/ml, median lethal time (LT50) values...
Abstract Exclusive breastfeeding (EBF) is affected by multiple risk factors. Therefore, it difficult for clinical professionals to identify women who will not practice EBF well and provide subsequent medical suggestions treatments. This study aimed apply a decision tree (DT) model predict at two months postpartum. The socio-demographic, parameters of 1,141 from Nanjing were evaluated. Decision modelling was used analyse screen factors establish assessment EBF. Chinese version the...
Assisted reproductive technology (ART) has been used globally among infertile couples. However, many epidemiological investigations have indicated that ART is associated with a range of long-term adverse health outcomes in offspring, including cardiovascular disease, obesity, and increased plasma lipid levels. Until now, direct evidence limited regarding the pathological changes vascular function fetuses ART. In this study, human umbilical cords were collected from healthy normal pregnancies...