A5103265368- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Neuroscience of respiration and sleep
- Systemic Lupus Erythematosus Research
- Nitric Oxide and Endothelin Effects
- Maternal and fetal healthcare
- Adipose Tissue and Metabolism
- Mechanical Circulatory Support Devices
- Healthcare Decision-Making and Restraints
- Inflammatory Biomarkers in Disease Prognosis
- Sodium Intake and Health
- Mitochondrial Function and Pathology
- Nosocomial Infections in ICU
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy and Medication Impact
- Gestational Diabetes Research and Management
- Gestational Trophoblastic Disease Studies
- Bone Metabolism and Diseases
- Neurological Complications and Syndromes
- Circadian rhythm and melatonin
- Parvovirus B19 Infection Studies
- Cardiac Ischemia and Reperfusion
Affiliated Hospital of Jining Medical University
2020-2025
Nanchang University
2020-2025
Second Affiliated Hospital of Nanchang University
2020-2024
Soochow University
2015-2021
First Affiliated Hospital of Soochow University
2015-2021
Jining Medical University
2021
Sun Yat-sen University
2017
Neutrophil extracellular traps (NETs) is an important process involved in the pathogenesis of systemic lupus erythematosus (SLE), but potential mechanisms NETs contributing to SLE at genetic level have not been clearly investigated. This investigation aimed explore molecular characteristics NETs-related genes (NRGs) based on bioinformatics analysis, and identify associated reliable biomarkers clusters. Dataset GSE45291 was acquired from Gene Expression Omnibus repository used as a training...
Abstract Background Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease characterized by clinical and pathological diversity. Mitochondrial dysfunction has been identified as critical pathogenetic factor in SLE. However, the specific molecular aspects regulatory roles of this SLE are not fully understood. Our study aims to explore characteristics mitochondria-related genes (MRGs) SLE, with focus on identifying reliable biomarkers for classification therapeutic purposes....
Prenatal high sucrose diet (HS) generates profound effects on vascular diseases in offspring later life. This study aimed to determine whether and how prenatal HS affect vasoreactivity resistance arteries from adult offspring. Pregnant Sprague-Dawley rats were fed with normal drinking water or 20% high-sucrose solution during the whole gestational period. Mesenteric (MAs) obtained tested for functions DMT. The whole-transcriptome sequencing (RNA-seq) of MAs was performed reveal different...
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have great potential in biomedical applications.However, the immature state of obtained using existing protocols limits application hPSC-CMs.Unlike adult cardiac myocytes, hPSC-CMs generate ATP through an metabolic pathway-aerobic glycolysis, instead mitochondrial oxidative phosphorylation (OXPHOS).Hence, switching is critical for functional maturation hPSC-CMs.Peroxisome proliferator-activated receptor gamma coactivator 1α...
Abstract Systemic lupus erythematosus (SLE), a chronic autoimmune disease, is marked by impaired immune tolerance and heightened activity in both innate adaptive systems. Hallmarks of SLE include elevated type I interferons autoantibody production, though the exact causes remain elusive despite advances research techniques. Crucial to understanding its pathogenesis developing effective diagnostic therapeutic methods. Recent studies have highlighted significant link between mitochondrial...
Background One of the most terrible famines last century was Great Chinese Famine (GCF) in 1959~1961 when millions people died from starving. Under-nutrition during famine between Western and Eastern (Dutch Hungry vs. GCF) similar, while cardiovascular consequences might not be same. Addressing such questions may gain new insight into prevention diseases. Methods A retrospective cohort 18,593 participants aged 43–49 years old, Suzhou, China. Logistic regression model used to calculate...
Scope Prenatal nutrition imbalance correlates with developmental origin of cardiovascular diseases; however whether maternal high‐sucrose diet (HS) during pregnancy causes vascular damage in renal interlobar arteries (RIA) from offspring still keeps unclear. Methods and results Pregnant rats are fed normal drinking water or 20% solution the whole gestational period. Swollen mitochondria distributed myofilaments observed smooth muscle cells RIA exposed to prenatal HS. Maternal HS increases...
// Qinqin Gao 1,* , Jiaqi Tang Na Li Xiuwen Zhou Xiaolin Zhu 1 Weisheng Bailin Liu Xueqin Feng Jianying Tao 1,3 Bing Han 3 Hong Zhang Miao Sun and Zhice Xu 1,2 Institute for Fetology, First Affiliated Hospital of Soochow University, Suzhou, China 2 Center Perinatal Biology, Loma Linda California, USA Department Obstetrics Gynecology, Second Municipal Hospital, * These authors have contributed equally to this work Correspondence to: Xu, email: Sun, Keywords : nitric oxide, cGMP/sGC pathway,...
Background . Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that commonly causes kidney damage. Therefore, we measured plasma levels of cytokines may be related to renal dysfunction in SLE patients. Methods To explore the differences between patients with and healthy volunteers, were screened using human cytokine antibody array. Then, chose fourteen elevated for verification an expanded sample size by magnetic Luminex assay. Plasma samples isolated from...
Background/Aims: Chronic hypoxia in utero could impair vascular functions the offspring, underlying mechanisms are unclear. This study investigated functional alteration large-conductance Ca2+-activated K+ (BK) channels offspring mesenteric arteries following prenatal hypoxia. Methods: Pregnant rats were exposed to normoxic control (21% O2, Con) or hypoxic (10.5% Hy) conditions from gestational day 5 21, their 7-month-old adult male tested for blood pressure, BK channel and expression using...
Prenatal hypoxia is suggested to be associated with increased risks of hypertension in offspring. This study tested whether prenatal resulted salt-sensitive offspring and its related mechanisms vascular ion channel remodeling.Pregnant rats were housed a normoxic (21% O2) or hypoxic (10.5% chamber from gestation days 5 21. A subset male received high-salt diet (8% NaCl) 4 12 weeks after birth. Blood pressure was significantly only the salt-loading exposed hypoxia, not that regular diets...
Abstract Human placental vessels (HPVs) play important roles in the exchange of metabolites and oxygen maternal-fetal circulation. Endothelial-derived prostacyclin (prostaglandin I2, PGI2) is a critical endothelial vasodilator body. However, physiological pharmacological functions PGI2 human placenta are still unclear. Human, sheep, rat blood were used this study. Unlike non-placental (non-PVs), synthesis inhibitor tranylcypromine (TCP) did not modify 5-hydroxytryptamine (5-HT)-induced...
Scope The fetal programming in response to over‐nutrition during pregnancy is involved pathogenesis of cardiovascular diseases later life. authors’ previous work reported that prenatal high‐sucrose (HS) diet impaired functions large‐conductance Ca 2+ ‐activated K + channels (BK) mesenteric arteries the adolescent offspring rats. This study determines whether HS has a long‐term impact on resistance vasculature aged Methods and results Pregnant rats are fed with until delivery. Aged from...
Background: Placental blood vessels play important roles in maternal-fetal circulation. Although pathologic mechanisms of preeclampsia are unclear, it is known that placental vascular dysfunction could contribute to pregnant hypertension. However, micro-vessel function or at preterm has not been investigated. Methods: Human placentas from normal and preeclamptic pregnancies term were obtained. micro-vessels used for determining tension responses various vasoconstrictors as well intracellular...
Overnutrition during pregnancy could increase risks of cardiovascular diseases in late life. This study investigated whether and how reactive oxygen species (ROS) may influence functions large-conductance Ca2+-activated K+ channels (BKCa) the offspring exposed to prenatal high sucrose (HS). We found that HS diets significantly increased phenylephrine (PE)-induced vessel contractions mesenteric arteries adult offspring. Pretreatment with iberiotoxin (BKCa blocker, IBTX) PE-mediated vascular...
Abstract Background This study aimed to examine whether and how postnatal high‐fat diet had additional impact on promoting vascular dysfunction in the offspring exposed prenatal hypoxia. Methods Results Pregnant Sprague‐Dawley rats were randomly assigned hypoxia (10.5% oxygen) or normoxia (21% O 2 ) groups from gestation days 5‐21. A subset of male was placed a ( HF , 45% fat) 4‐16 weeks age. Prenatal induced decrease birth weight. In offspring‐fed diet, associated with increased fasting...
The co-stimulatory molecule B7-H3, a cell surface transmembrane glycoprotein, was assessed for its functional and prognostic role in lichen simplex chronicus (LSC).To investigate if abnormal expression of the B7-H3 LSC is associated with Langerhans (LC) expansion.We used immunohistochemistry to stain skin tissue, evaluated immunostaining interleukin (IL)-6 significantly different.Our results indicated that abnormally expressed tissue positively regulates LC expansion. We also found IL-6...