A5112121352- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Pneumocystis jirovecii pneumonia detection and treatment
- Adenosine and Purinergic Signaling
- E-commerce and Technology Innovations
- Luminescence Properties of Advanced Materials
- Optical Network Technologies
- Energy, Environment, Economic Growth
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Advanced Neural Network Applications
- Inorganic Fluorides and Related Compounds
- Urbanization and City Planning
- ZnO doping and properties
- Language, Metaphor, and Cognition
- Economic and Technological Innovation
- Corporate Finance and Governance
- Software-Defined Networks and 5G
- Neural Networks and Reservoir Computing
- Error Correcting Code Techniques
- Nanoparticle-Based Drug Delivery
- Wireless Communication Security Techniques
- X-ray Diffraction in Crystallography
- Numerical Methods and Algorithms
- Ga2O3 and related materials
Chongqing Medical University
2021-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Southwest University
2024
Southwestern University of Finance and Economics
2023-2024
Xi’an University of Posts and Telecommunications
2011-2023
Northwest A&F University
2022
Chengdu Sport University
2022
PetroChina Southwest Oil and Gas Field Company (China)
2022
Zhengzhou University
2020
Shanghai University of Political Science and Law
2011
Abstract The limited infiltration of CD8+ T cells in tumors hampers the effectiveness cell–based immunotherapy, yet mechanisms that limit tumor by remain unclear. Through bulk RNA sequencing human tumors, we identified a strong correlation between WNT7A expression and reduced T-cell infiltration. Further investigation demonstrated inhibiting substantially enhanced MHC-I on cells. Mechanistically, inhibition inactivated Wnt/β-catenin signaling pathway thus resulted physical interaction...
<p>Figure S3 WNT7A blockage inhibits tumor growth and enhances anti-tumor immunity.</p>
<p>Figure S6 Discovery of small chemical inhibitors targeting WNT7A–FZD5.</p>
<p>Figure S4 Inhibition of WNT7A leads to the upregulation MHC-I via NF-κB pathway.</p>
<p>Figure S2 Blocking WNT7A leads to an increase in MHC-I expression.</p>
<div>Abstract<p>The limited infiltration of CD8<sup>+</sup> T cells in tumors hampers the effectiveness cell–based immunotherapy, yet mechanisms that limit tumor by remain unclear. Through bulk RNA sequencing human tumors, we identified a strong correlation between WNT7A expression and reduced T-cell infiltration. Further investigation demonstrated inhibiting substantially enhanced MHC-I on cells. Mechanistically, inhibition inactivated Wnt/β-catenin signaling pathway...
<p>Figure S5 Blocking WNT7A synergizes with ICB.</p>
<p>Figure S1 High WNT7A expression correlates with low CTL cell infiltration, reduced MHC-I expression, and unfavorable patient survival.</p>
<p>Figure S7 1,365-0,109 improves ICB efficacy without significant toxic side effects.</p>
Astragalus variabilis is a locoweed of northwest China that can seriously impede livestock development. However, it also plays various ecological roles, such as wind protection and sand fixation. Here, we used an optimized MaxEnt model to predict the distribution suitable habitat A. under current (1970–2000) conditions future (2021–2080) climate change scenarios based on recent occurrence records. The most important environmental variables (suitability ranges in parentheses) affecting were...
The orthogonal time frequency space (OTFS) technique proposed in recent years has excellent anti-Doppler shift and delay performance, enabling its application high speed communication scenarios. In this article, a particle swarm optimization (PSO) signal detection algorithm for OTFS system is proposed, an adaptive mechanism the individual learning factor global formula of designed, position update method particles improved, so as to increase convergence accuracy avoid fall into local...
The elementary function approximation using piecewise quadratic polynomial interpolation requires larger area of the look-up table (LUT) and circuit. To solve problem, this paper presents an algorithm for in single-precision floating-point format, which is based on minimax cubic approximation. can efficiently achieve reciprocal, square root, root exponentials, logarithm, trigonometric format. According to range parameters narrowed first, then we get optimal truncated bit width coefficients...
In this work, one-step solvothermal synthesis of KBi 3 F 10 :Eu 3+ phosphors and sensitive detection Cr , CrO 4 2− 2 O 7 ions in solution are presented.
It is important to enhance penetration depth of nanomedicine and realise rapid drug release simultaneously at targeted tumour for improving anti-tumour efficiency chemotherapeutic drugs. This project employed sodium alginate (Alg) as matrix material, establish tumour-responsive nanogels with particle size conversion controlled functions. Specifically, tumour-targeting peptide CRGDK was conjugated Alg first (CRGDK-Alg). Then, doxorubicin (DOX) efficiently encapsulated in CRGDK-FeAlg nanogel...
Mixed-precision quantization can compress the size of Convolution Neural Networks (CNNs) without reducing accuracy network. A fixed bit width CNN accelerator needs to match largest in mixed- precision CNNs, which cause a huge waste resource. In order multiple we propose reconfigurable microprocessing element (RmPE) that supports multi-precision parallel multiplication and addition operations. After testing, when with RmPE infers mixed-precision VGG-16 ResNet-50 on Ultra96-V2 platform,...
In order to improve the accuracy of feature classification and reduce identification time, this study designed a recognition method soccer players' leg movements based on decision tree algorithm. Firstly, basis collecting movement images players, image quality is improved by preprocessing. Then, players are classified algorithm, sequence potential function established according results. Finally, AdaBoost algorithm used identify characteristics players. The experimental results show that...