A5029341426- Extracellular vesicles in disease
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- interferon and immune responses
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Wound Healing and Treatments
- Amoebic Infections and Treatments
- Antimicrobial agents and applications
- Cancer, Hypoxia, and Metabolism
- Erythrocyte Function and Pathophysiology
- Gout, Hyperuricemia, Uric Acid
- Reproductive System and Pregnancy
- Advanced Nanomaterials in Catalysis
- Linguistic Variation and Morphology
- Iron Metabolism and Disorders
- Cardiac Fibrosis and Remodeling
- Antimicrobial Peptides and Activities
- Bone and Joint Diseases
- Bacterial Infections and Vaccines
- Heme Oxygenase-1 and Carbon Monoxide
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Air Force Medical University
2020-2025
State Council of the People's Republic of China
2022
Office for Students
2016
As the major interface between body and external environment, skin is liable to various injuries. Skin injuries often lead severe disability, exploration of promising therapeutic strategies great importance. Exogenous mesenchymal stem cell (MSC)-based therapy a potential strategy due apparent effects, while underlying mechanism still elusive. Interestingly, we observed extensive apoptosis exogenous bone marrow cells (BMMSCs) in short time after transplantation mouse wound healing models....
Chimeric apoptotic bodies promote M2 polarization of macrophages to modulate inflammation.
Inflammatory response plays a critical role in myocardial infarction (MI) repair. The neutrophil apoptosis and subsequent macrophage ingestion can result inflammation resolution initiate regeneration, while the therapeutic strategy that simulates enhances this natural process has not been established. Here, we constructed engineered apoptotic bodies (eNABs) to simulate apoptosis, which regulated enhanced MI eNABs were fabricated by combining body membrane excellent inflammation-tropism...
Inflammation plays a crucial role in triggering regeneration, while inadequate or chronic inflammation hinders the regenerative process, resulting refractory wounds. Inspired by ideal regeneration mode lower vertebrates and human oral mucosa, realigning dysregulated to heightened acute response provides promising option for wound therapy. Neutrophils play important roles initiation resolution. Here, hybrid biomaterial is used stimulate transiently inflammatory responses precise tempospatial...
Estrogen deficiency is one of the most frequent causes osteoporosis in postmenopausal women. Under chronic inflammatory conditions caused by estrogen deficiency, activated T cells contribute to elevated levels proinflammatory cytokines, impaired osteogenic differentiation capabilities bone marrow mesenchymal stem (BMMSCs), and disturbed regulatory cell (Treg)/Th17 balance. However, therapeutic strategies that re-establish immune homeostasis this disorder have not been well developed. Here,...
Background: Osteoporosis is a highly prevalent disease that causes fractures and loss of motor function. Current drugs targeted for osteoporosis often have inevitable side effects. Bone marrow mesenchymal stem cell (BMSCs)-derived apoptotic extracellular vesicles (ApoEVs) are nanoscale vesicles, which has been shown to promote bone regeneration with low immunogenicity high biological compatibility. However, natural ApoEVs cannot inherently target bones, eliminated by macrophages in the liver...
Although stem cell therapy is proved to be a promising strategy for bone repair and regeneration, transplanted allogeneic cells generally suffer from unfavorable apoptosis instead of differentiation into osteocytes. How the apoptotic promote regeneration still needs uncovered. In this work, we found that extracellular vesicles released by are critical mediators promoting regeneration. Based on results in vivo experiments, mechanism determined autologous recruitment enhance osteogenesis was...
Abstract Radiation enteritis is the most common complication of pelvic radiotherapy, but there no effective prevention or treatment drug. Apoptotic T cells and their products play an important role in regulating inflammation maintaining physiological immune homeostasis. Here it shown that systemically infused cell‐derived apoptotic extracellular vesicles (ApoEVs) can target mice irradiated intestines alleviate radiation enteritis. Mechanistically, elevates synthesis intestinal 2′3′ cyclic...
The application of apoptotic extracellular vesicles (ApoEVs) derived from stem cell in skin wound healing has garnered significant attention. In recent decades, scholars have shown that (EVs) established intercellular communication by carrying proteins or microRNAs, the role lipids EVs yet to be clarified. Here, we focus on key group X secretory phospholipase A2 (sPLA2-X) lipid metabolism. Specifically, sPLA2-X significantly increased production anti-inflammatory mediators, resolvin D5...
Bacterial infection is one of serious problems hindering tissue regeneration, but strategies able to perform proper antibiosis with spatiotemporal controllability manipulate the local inflammation and immunity for effective healing infected wound still a challenge. Herein, we fabricated smart hydrogel ([email protected]) multiple responsiveness near infrared radiation, visible light, hyaluronidase hydrogen peroxide promoted via controllable anti-bacteria at designed locations time periods as...
Abstract Sepsis poses a significant challenge in clinical management. Effective strategies targeting iron restriction, toxin neutralization, and inflammation regulation are crucial combating sepsis. However, comprehensive approach simultaneously these multiple processes has not been established. Here, an engineered apoptotic extracellular vesicles (apoEVs) derived from macrophages is developed their potential as multifunctional agents for sepsis treatment investigated. The extensive...
Type 2 diabetes mellitus (T2DM) exacerbates irreversible bone loss in periodontitis, but the mechanism of impaired regeneration caused by abnormal metabolic process T2DM remains unclear. Exosomes are regarded as critical mediator diabetic impairment via organ or tissue communication. Here, we find that abnormally elevated exosomes derived from metabolically liver significantly enriched periodontal region and induced pyroptosis ligament cells (PDLCs). Mechanistically, fatty acid synthase...
The present study aimed to evaluate the feasibility, accuracy, and clinical effect of intraoperative navigation for resection elongated styloid process (ESP) in Eagle's syndrome.Twelve patients with syndrome clinically radiologically established diagnoses ESP were included this study. Preoperatively, all accepted three-dimensional computed tomography scan, their skulls' digital imaging communications medicine data inputed into system workstation make a virtual surgical plan advance. During...
Psychological stress emerges to be a common health burden in the current society for its highly related risk of mental and physical disease outcomes. However, how quickly-adaptive response process connects long-observed organismal alterations still remains unclear. Here, we investigated profile circulatory extracellular vesicles (EVs) after acute (AS) restraint mice by phenotypic proteomic analyses. We surprisingly discovered that AS-EVs demonstrated significant changes size distribution...
Abstract Immediate iron restriction by the host is a critical process to protect against bacterial infections. Although cell-dependent sequestration mechanism in liver or spleen has been identified, it still unclear that whether launched humoral regulation promptly acquire widely distributes throughout body fluids. Here, we showed after invasion, immediately releases nanosized exosomes capture circulating iron-containing proteins, which required for prompt systemic and antibacterial defense....
Psychological stress emerges to be a common health burden in the current society for its highly related risk of mental and physical disease outcomes. However, how quickly-adaptive response process connects long-observed organismal alterations is still unclear. Here, we investigated profile circulating extracellular vesicles (EVs) after acute (AS) restraint mice by phenotypic proteomic analyses. We surprisingly discovered that AS-EVs demonstrated significant changes size distribution plasma...