A5100620146- Craniofacial Disorders and Treatments
- dental development and anomalies
- Autophagy in Disease and Therapy
- COVID-19 Impact on Reproduction
- Animal Virus Infections Studies
- Erythrocyte Function and Pathophysiology
- Esophageal and GI Pathology
- Folate and B Vitamins Research
- Cleft Lip and Palate Research
- Enhanced Recovery After Surgery
- Porphyrin Metabolism and Disorders
- SARS-CoV-2 and COVID-19 Research
- Neonatal Health and Biochemistry
- Ophthalmology and Visual Impairment Studies
- Ocular Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Glaucoma and retinal disorders
- Resilience and Mental Health
- Poxvirus research and outbreaks
- Neonatal Respiratory Health Research
- Oral and Craniofacial Lesions
- Music Therapy and Health
- Lipid metabolism and disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Wound Healing and Treatments
National Clinical Research Center for Digestive Diseases
2024-2025
Capital Medical University
2023-2025
Beijing Friendship Hospital
2023-2025
Air Force Medical University
2020-2024
Huazhong University of Science and Technology
2020-2024
Tongji Hospital
2020-2024
Hunan Provincial Maternal and Child Health Hospital
2024
Nanjing University
2023
South China Agricultural University
2022
Northwest A&F University
2021
The aim of this study was to investigate the clinical characteristics neonates born SARS-CoV-2 infected mothers and increase current knowledge on perinatal consequences COVID-19. Nineteen were admitted Tongji Hospital from January 31 February 29, 2020. Their clinically diagnosed or laboratory-confirmed with We prospectively collected analyzed data infants. There are 19 included in research. Among them, 10 confirmed COVID-19 by positive RT-PCR throat swab, 9 Delivery occurred an isolation...
Mesenchymal stem cell (MSC) transplantation has been widely applied as a potential therapeutic for multiple diseases. However, the underlying mechanisms are not fully understood, especially paradox between low survival rate of transplanted cells and beneficial effects generated by these cells. Herein, in myocardial infarction (MI) model, we found that MSCs released apoptotic bodies (ABs) to enhance angiogenesis improve cardiac functional reclovery via regulating macroautophagy/autophagy...
Inflammation plays a crucial role in triggering regeneration, while inadequate or chronic inflammation hinders the regenerative process, resulting refractory wounds. Inspired by ideal regeneration mode lower vertebrates and human oral mucosa, realigning dysregulated to heightened acute response provides promising option for wound therapy. Neutrophils play important roles initiation resolution. Here, hybrid biomaterial is used stimulate transiently inflammatory responses precise tempospatial...
Abstract The interplay between bacteria and their host influences the homeostasis of human immune microenvironment, this reciprocal interaction also affects process tissue damage repair. A variety immunomodulatory commensal reside in body, capable delivering membrane vesicles (MVs) to cells regulate local microenvironment. This research revealed, for initial time, significant enhancement mucosal cutaneous wound healing by MVs secreted Lactobacillus reuteri (RMVs) through modulation...
Isoflurane has a pharmacological preconditioning effect against ischemia injury in the heart, kidney, and brain, but whether how isoflurane protects livers reperfusion (IR) is unclear.Mice were randomly divided into an (ISO) group control group, receiving 1.5% or carrier gas for 40 minutes, respectively (n = 8/group). A partial warm liver IR model was used, evaluated. Primary hepatocytes pretreated with 2 hours before induction of cell death by hydrogen peroxide. Cell survival evaluated...
Acute pancreatitis (AP), an inflammatory disorder of the pancreas with a high hospitalization rate, frequently leads to systemic response syndrome (SIRS) and multiple organ dysfunction (MODS). However, therapeutic targets for effective treatment early intervention AP are still urgently required be identified. Here, we have observed that expression pancreatic lincRNA-EPS, long intergenic non-coding RNA, is dynamically changed during both caerulein-induced (Cer-AP) sodium taurocholate-induced...
Background: The detection of mutations from circulating tumor DNA (ctDNA) represents a promising enrichment technique. In this retrospective study, the significance ctDNA and imaging in Langerhans cell histiocytosis (LCH) monitoring was first examined, broader role LCH additionally explored. Methods: First, data visualization survival analysis models were used to generalize concordance between cfBRAFV600E molecular response radiographic on clinical outcomes. Next, observed dynamic...
The perinatal consequences of neonates born to severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) infected mothers are uncertain. This study aimed compare the differences in clinical manifestation, laboratory results, and outcomes with or without coronavirus disease 2019 (COVID-19).A total 48 were admitted Tongji Hospital HuangShi Maternal Child Healthcare from January 17 March 4, 2020. divided into three groups according mothers' conditions: confirmed COVID-19,...
Abstract Background Auriculocondylar syndrome (ARCND) is an extremely rare autosomal dominant or recessive condition that typically manifests as question mark ears (QMEs), mandibular condyle hypoplasia, and micrognathia. Severe dental maxillofacial malformations present considerable challenges in patients’ lives clinical treatment. Currently, only a few ARCND cases have been reported worldwide, but most of them are related to genetic mutations, symptoms, ear correction; there reports...
AbstractTo investigate the effects of palygorskite on chemical forms heavy metal and microbial functional diversity in sewage sludge composting, a compost matrix sludge, wheat straw varying contents were inoculated with compound preparation. The speciation analysis by Community Bureau Reference-sequential extraction indicated contribution to reduce bioavailability model metal, Cu, during composting process. Biolog EcoPlateTM test revealed that community showed better capability utilizing...
Excessive and uncontrolled induction release of proinflammatory cytokines chemokines, the so-called cytokine syndrome (CRS), would cause life-threatening complications multiple organ failure in severe coronavirus infections, including acute respiratory (SARS), Middle East (MERS) COVID-19. This study reveals that infection also induces expression ZFP36, an anti-inflammatory ARE-binding protein, promoting degradation ARE-containing transcripts coding for IL-6 IL-8 as well a number other...
The European Society of Gastrointestinal Endoscopy recommends routine clip closure for defects ≤ 20 mm following duodenal endoscopic mucosal resection or submucosal dissection (ESD) [1]. However, large sites that cannot be fully closed by this kind are associated with higher adverse event rates [2]. A through-the-scope twin (TTS-TC) can close wounds a size up to 4.8 cm via an endoscope working channel 3.2 [3]. We present initial application TTS-TC defect ([Video 1]).
Background: Hereditary spherocytosis (HS) is a congenital haemolytic anaemia attributed to dysregulation or abnormal quantities of erythrocyte membrane proteins. Currently, the most common erythrocytic gene, spectrin β (SPTB), variants are located in exons and give rise mRNA defects. However, genetic characteristics pathogenic mechanisms SPTB intronic not completely understood. This study aimed analyse rare inversion variant gene associated with HS, explore impact on splicing. Method: The...
The purpose of this study was to investigate the role DGUOK in pro-gression colorectal cancer (CRC) and its impact on sensitivity CRC cells 5-FU treatment.
Auriculocondylar syndrome (ARCND) is an extremely rare monogenic condition; fewer than 100 cases of ARCND have been reported in the literature, and there are few reports on its treatment. Here, we present a novel guanine nucleotide-binding protein alpha-inhibiting activity polypeptide 3 (GNAI3) mutation Chinese patient with clinical features patient’s family. Sequential preoperative orthodontic treatment craniofacial surgery using digital technology were performed to treat dentofacial...
<title>Abstract</title> Background Auriculocondylar syndrome (ARCND) is an extremely rare autosomal dominant or recessive condition and the typical triad manifestations of ARCND are question mark ears (QMEs), mandibular condyle hypoplasia, micrognathia. This severe dental maxillofacial malformations have caused great trouble to patient’s life clinical treatment. Now only a few cases reported in world, but most them about genetic mutations, symptoms, ear correction, reports concerning...