A5100741599- Heart Failure Treatment and Management
- Bone Metabolism and Diseases
- Bone and Dental Protein Studies
- dental development and anomalies
- Immune cells in cancer
- Cardiovascular Function and Risk Factors
- Chemokine receptors and signaling
- Neuroblastoma Research and Treatments
- Electrolyte and hormonal disorders
- Craniofacial Disorders and Treatments
- Galectins and Cancer Biology
- Potassium and Related Disorders
- Bone health and treatments
- Parathyroid Disorders and Treatments
- Cleft Lip and Palate Research
- Oral microbiology and periodontitis research
- Peptidase Inhibition and Analysis
- Temporomandibular Joint Disorders
- Anesthesia and Neurotoxicity Research
- Cardiac Health and Mental Health
- Oral and Maxillofacial Pathology
- Ion channel regulation and function
- Dental Trauma and Treatments
- S100 Proteins and Annexins
- Sepsis Diagnosis and Treatment
Peking University
2025
Peking University Cancer Hospital
2025
Hangzhou Medical College
2025
Shenzhen Children's Hospital
2025
Air Force Medical University
2012-2024
Huashan Hospital
2024
Fudan University
2024
Chinese PLA General Hospital
2023-2024
First Hospital of China Medical University
2023-2024
China Medical University
2023-2024
Objectives: Otitis media is one of the most important causes hearing loss at an early age. Effective vaccination with routine 7-valent pneumococcal conjugate vaccine (PCV-7) was introduced in 2000. It has been gradually replaced by nontypeable Haemophilus influenzae protein D or higher-valent 13-valent PCV (PCV-13) since 2010. Data on change otitis burden recent years are sparse global, regional, and national levels. Design: The Global Burden Disease 2019 study used to evaluate prevalence,...
Teratozoospermia is the main pathogenic factor of male infertility. However, genetic etiology teratozoospermia largely unknown. This study aims to clarify relationship between novel variations in TENT5D and infertile patients.
This study evaluates and compares ChatGPT-4.0, Gemini Pro 1.5(0801), Claude 3 Opus, Qwen 2.0 72B in answering dental implant questions. The aim is to help doctors underserved areas choose the best LLMs(Large Language Model) for their procedures, improving care accessibility clinical decision-making. Two specialists with over twenty years of experience evaluated models. Questions were categorized into simple true/false, complex short-answer, real-life case analyses. Performance was measured...
The psychological symptoms of temporomandibular joint (TMJ) ankylosis were similar to that depressive disorder, but there no relevant evidences confirm the humans or animals with TMJ had disorder. aim this study was investigate association between and disorder in rat model. Thirty 3-week-old male Sprague-Dawley (SD) rats used study. damage complexes narrowed space performed unilateral test group induce bony (experimental side). other underwent a sham operation (sham TMJs control did not...
Abstract Objectives To clarify the possible role and mechanism of Cathepsin K (CTSK) in alveolar bone regeneration mediated by jaw marrow mesenchymal stem cells (JBMMSC). Materials Methods Tooth extraction models Ctsk knockout mice ( ‐/‐ ) their wildtype (WT) littermates were used to investigate effect CTSK on regeneration. The influences deletion or inhibition odanacatib (ODN) proliferation osteogenic differentiation JBMMSC assessed CCK‐8, Western blot alizarin red staining. explore...
Chronic changes caused by a high-fat diet (HFD) may be associated with weakened lung function in obese patients. However, few studies have focused on the role of senescent cells HFD-induced pulmonary fibrosis. This study aimed to determine whether (i) obesity causes accumulation aging lungs, (ii) p16 epithelial or fibroblasts exacerbates long-term senescence-associated fibrosis (SAPF) and (iii) deletion clearance ameliorates SAPF through inactivation inflammasome metabolic...
Objective To investigate the safety and efficacy of servo-controlled cooling during transport neonates with perinatal asphyxia. Methods We conducted a retrospective non-randomized case-control study at single-center,which included 65 diagnosed Hypoxic-Ischemic Encephalopathy (HIE). These were referred by Shenzhen Children's Hospital medical team between January 2020 June 2024. All subjects received 72 h mild hypothermia treatment upon admission. Participants categorized into an active group...
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare inherited disorder of the peripheral nervous system resulting from mutations in neurotrophic tyrosine kinase receptor 1 gene (NTRK1), which encodes high-affinity nerve growth factor TRKA. Here, we investigated oral and craniofacial manifestations Chinese patient affected by autosomal-recessive CIPA identified compound heterozygosity NTRK1 gene. The boy has multisystemic lack reaction stimuli accompanied self-mutilation...
Cathepsin K (CTSK) is an important protease responsible for degrading type I collagen, osteopontin, and other bone matrix proteins. The mutations in the CTSK gene can cause pycnodysostosis (OMIM 265800), a rare autosomal recessive dysplasia. Patients with have been reported to present specific dental abnormalities; however, whether these abnormalities are related dysfunctional has never reported. Here we investigated histologic changes of cementum alveolar patient, caused by novel compound...
ClC-3 chloride channel has been speculated to contribute the acidification of synaptic vesicles and endosomes. However, biological function in osteogenesis remains be determined. In this study, we first analyzed expression MC3T3-E1 cells primary mouse osteoblasts then performed osteoinductive procedure determine effects on gene expression. Subsequently, transiently transfected cDNA or ClC-3-siRNA into changed phenotype Lastly, assessed underlying mechanism responsible for ClC-3-induced...
Lipoid proteinosis (LP) is known to be resulted from mutations of the extracellular matrix protein 1 gene (ECM1). However, no effective or sustained therapeutic methods alleviate LP symptoms have been reported. Here, we report a 12-year-old boy with and recurrent anaphylaxis. The laboratory histopathological investigations were adopted confirm diagnosis, sequencing was performed. We treated this patient glucocorticoid for three years relieve patient's lipid metabolism disorder related...
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause (CF). Both CF and dental fluorosis result protein retention mature enamel. We hypothesized that excess fluoride might by interfering with CFTR function, resulting abnormal expression of proteases pathological endocytosis. Millimolar concentrations reduced uptake Emdogain, an enamel matrix derivative, ameloblast-like PABSo-E cells, while stimulating acidic intracellular environment at same time. When...