A5101529952- Ocular Surface and Contact Lens
- Fungal Biology and Applications
- Microbial Inactivation Methods
- Cancer-related molecular mechanisms research
- Algal biology and biofuel production
- Magnetic and Electromagnetic Effects
- Asthma and respiratory diseases
- Corneal Surgery and Treatments
- Epilepsy research and treatment
- Chemical synthesis and alkaloids
- Corneal surgery and disorders
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Neuroscience and Neuropharmacology Research
- Advanced Photocatalysis Techniques
- Polysaccharides and Plant Cell Walls
- IL-33, ST2, and ILC Pathways
- Advanced oxidation water treatment
- Coenzyme Q10 studies and effects
- Cerebrospinal fluid and hydrocephalus
- Advanced Drug Delivery Systems
- Toxin Mechanisms and Immunotoxins
- Medicinal Plants and Neuroprotection
- Phagocytosis and Immune Regulation
- Pituitary Gland Disorders and Treatments
Sun Yat-sen University
2023-2025
Beijing Tian Tan Hospital
2025
Capital Medical University
2025
Jinan University
2024
East China University of Science and Technology
2024
Guilin Medical University
2024
Zhengzhou Children's Hospital
2017-2023
University of Shanghai for Science and Technology
2021-2022
Northwest University
2022
First Affiliated Hospital of Xi'an Jiaotong University
2020-2021
In this study, we investigated the hepatoprotective effects of AdA and underlying mechanism at liver metabolomics gut microbiota levels under alcohol-induced injury conditions.
It is imperative to devise effective removal strategies for high ionization potential (IP) organic pollutants in wastewater as their reduced electron-donating capacity challenges the efficiency of advanced oxidation systems degradation. Against this backdrop, leveraging metal-based carbon material structure meticulously, we employed metal-pyridine-N (M-N-C, M=Fe, Co, and Ni) electron transfer bridge. This distinctive design facilitated ordered electrons from adsorbent surface IP value...
Abstract Circadian disruption, as a result of shiftwork, jet lag, and other lifestyle factors, is common public health problem associated with wide range diseases, such metabolic disorders, neurodegenerative cancer. In the present study, we established chronic lag model using time shift method every 3 days assessed effects circadian disruption on ocular surface homeostasis. Our results indicated that increased corneal epithelial defects, cell apoptosis, proinflammatory cytokine expression....
Abstract Dry eye disease (DED) is a multifaceted ocular surface disorder that significantly impacts patients’ daily lives and imposes substantial economic burden on society. Oxidative stress, induced by the overproduction of reactive oxygen species (ROS), critical factor perpetuating inflammatory cycle in DED. Effectively scavenging ROS essential to impede progression In this study, boronophenylalanine‐ containing polydopamine (PDA‐PBA) nanoparticles are developed loaded with melatonin (MT),...
The role of the conjunctiva in pathophysiology Sjögren's syndrome (SS) related dry eye disease (DED) remains obscure especially view functional conjunctival epithelia. In order to illustrate effects SS, we investigated interactions between parenchymal cells and immune with single-cell RNA sequencing technique. Freshly collected from a canonical SS model was prepared for 10 × Genomics T cell receptor (TCR) sequencing. Conjunctiva Western blot, immunofluorescence, multiplex immunohistochemical...
α-Asaronol from Acorus tatarinowii (known as "Shichangpu" in Traditional Chinese medicine) has been proved to possess more efficient antiepileptic activity and lower toxicity than α-asarone (namely "Xixinnaojiaonang" an drug China) our previous study. However, the molecular mechanism of α-asaronol against epilepsy needs be known if become a novel medicine. Nuclear magnetic resonance (NMR)-based metabolomics was applied investigate metabolic patterns plasma brain tissue extract...
The accumulation of giant lipid droplets (LDs) increases the risk metabolic disorders including obesity and insulin resistance. lipolysis process involves activation transfer lipase, but molecular mechanism is not completely understood. translocation ATGL, a critical from ER to LD surface mediated by an energy catabolism complex. Oxysterol-binding protein-like 2 (OSBPL2/ORP2) one proteins that regulates intracellular cholesterol homeostasis. A recent study has proven Osbpl2−/− pigs exhibit...
Niemann-Pick type C disease (NPCD) is a rare genetic syndrome characterized by cholesterol accumulation in multiple organelles. NPCD mainly caused gene deficiency of NPC intracellular transporter 1 (NPC1). It has been reported that some the patients exhibit clinical features progressive hearing loss at high frequency and iron disorder, but underlying relationship unknown. A recent study ferroptosis contributes to impairment cochlear hair cells are related sensory hearing. In this study, we...
BACKGROUND Bronchial epithelial cells proliferation plays a pivotal role in airway remodeling children with severe asthma. MicroRNAs (miRNAs) have gained great attention for many diseases, including The purpose of this study was to explore the mechanisms that underlie miR-744 modulating bronchial asthma children. MATERIAL AND METHODS were isolated from biopsies normal controls and asthmatic subjects. transforming growth factor-ß1 (TGF-ß1) expressions measured by quantitative reverse...
Antrodia camphorata is rich in a variety of bioactive ingredients; however, the utilization efficiency residue A. low, resulting serious waste. It necessary to deeply study functional components residues achieve high-value utilization. In this study, components, structural characteristics, and properties alkali-extracted dietary fiber extracted from (basswood dish cultured fruiting body, respectively) were investigated. There similar characteristics ACA-DK (extract basswood cultured) ACA-DF...
The purpose of the study was to detect level T-helper type 9 (Th9) cells and cytokine interleukin-9 (IL-9) in peripheral blood mice with bronchial asthma, explore relationship between expression Th9 pathogenesis asthma. Thirty female‑specific pathogen-free (SPF) Bagg' albino (BALB)/c were selected randomly divided into control group (n=15) observation (n=15). Mice treated ovalbumin (OVA) for sensitization induction a mouse model airway reactivity measured by pulmonary function apparatus...
Asthma is the most common chronic childhood disease worldwide, characterized by airway remodeling and inflammation, orchestrated primarily Th2 cytokines. The aim of current study was to explore influences milk fat globule epidermal growth factor 8 (MFG-E8)/integrin β3 signaling involved in inflammation asthma. BALB/c mice were sensitized intraperitoneal injection ovalbumin (OVA), followed OVA nebulization. levels MFG-E8 expression declined markedly OVA-induced allergy murine model. In...
Abstract Background Irreversible electroporation (IRE) is an emerging tissue ablation technique with widespread potential, especially for cancer treatment. Although the safety and efficacy of IRE gastric have been demonstrated, there a gap knowledge regarding effect pulse (EP) on physiology histopathology stomach. This study applied EP to stomach healthy rats investigated digestive function, serum marker levels, structure EP-treated rats. Methods Ninety male were divided into nine groups...
Abstract The solid-state fermentation of Antrodia camphorata could produce a variety ubiquinone compounds, such as antroquinonol (AQ). However, AQ is hardly synthesized during liquid-state (LSF). To investigates the mechanism synthesis, three precursors (ubiquinone 0 UQ0, farnesol and farnesyl diphosphate FPP) were added in LSF. results showed that UQ0 successfully induced production; however, FPP not induce synthesis. precursor restricts synthesis quinone ring, isoprene side chain. Then,...
Zhong, Guangyao MB; Liang, Lihong MM; Chen, Xiaozhuo Guorong Huang, Chengzhao Lin, Ping Kuang, Zhongshen MM, MD Author Information
BackgroundAsthma is a chronic inflammatory disorder with high prevalence in childhood. Airway remodeling, an important structural change of the airways, resulted from epithelial-mesenchymal transition. Long non-coding RNA activated by DNA damage (NORAD) has been found to promote transition multiple cancers. This study aimed analyze role NORAD asthma, mainly focusing on transition-mediated airway and further explored NORAD-miRNA-mRNA network.MethodsNORAD expression was analyzed transforming...
The effect of CASZI on bronchopulmonary development in neonatal rats was investigated. Forty SD were randomly divided into the control group (n=20) and experimental using a random number table. treated with hyperoxia to establish dysplasia (BPD) model, while received no treatment. At 14 days experiment, each treated, lung tissues taken for hematoxylin eosin (H&E) staining. Radial alveolar count (RAC) morphological changes observed under microscope, thickness respiratory membrane detected via...
<title>Abstract</title> Circadian disruption, as a result of shiftwork, jet lag and other lifestyle factors, is common public health problem associated with wide range diseases, such metabolic disorders, neurodegenerative diseases cancer. In the present study, we established chronic model using time shift every 3 days method assessed effects circadian disruption on ocular surface homeostasis. Our results indicated that increased corneal epithelial defects, cell apoptosis, proinflammatory...