A5102258365- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Digital Media and Visual Art
- China's Socioeconomic Reforms and Governance
- Connexins and lens biology
- Extracellular vesicles in disease
- Developmental Biology and Gene Regulation
- Vestibular and auditory disorders
- Orthopaedic implants and arthroplasty
- Acoustic Wave Phenomena Research
- Pancreatic function and diabetes
- E-commerce and Technology Innovations
- Circular RNAs in diseases
- Privacy, Security, and Data Protection
- Orthopedic Infections and Treatments
- Plant Molecular Biology Research
- Adipose Tissue and Metabolism
- Cybersecurity and Cyber Warfare Studies
- Bone Tissue Engineering Materials
- Lipid metabolism and biosynthesis
- Inflammasome and immune disorders
Zhongda Hospital Southeast University
2024-2025
State Key Laboratory of Digital Medical Engineering
2024-2025
Southeast University
2024
Chinese Academy of Social Sciences
2017-2021
Nanjing Medical University
2020
Jining First People's Hospital
2018-2019
Abstract Neonatal cochlear Lgr5+ progenitors retain limited hair cells (HCs) regenerative capacity, but the regulatory network remains incompletely defined. Serpin family E member 2 ( Serpine2 ) is shown to participate in regulating proliferation and differentiation of previous vitro study. Here, expression pattern vivo roles HC regeneration are explored by transgenic mice. It found that expressed mouse cochlea after birth with a downward trend as mice age. In addition, conditional...
Abstract Cisplatin‐induced ototoxicity remains a clinical dilemma with limited mechanistic understanding and no food drug administration (FDA)‐approved therapies. Despite emerging roles of small extracellular vesicles (sEV) in ototoxicity, their molecular cargo profiles causal to cisplatin‐induced are unexplored. This study systematically investigates sEV derived from cochlear explants treated cisplatin (Cis‐sEV) controls (Ctrl‐sEV) using multi‐omics profiling. Through RNA sequencing, 83...
The accumulation of giant lipid droplets (LDs) increases the risk metabolic disorders including obesity and insulin resistance. lipolysis process involves activation transfer lipase, but molecular mechanism is not completely understood. translocation ATGL, a critical from ER to LD surface mediated by an energy catabolism complex. Oxysterol-binding protein-like 2 (OSBPL2/ORP2) one proteins that regulates intracellular cholesterol homeostasis. A recent study has proven Osbpl2−/− pigs exhibit...
Abstract Small extracellular vesicles (sEVs) act as a critical mediator in intercellular communication. Compared to sEVs derived from vitro sources, tissue‐derived can reflect the vivo signals released specific tissues more accurately. Currently, studies on role of cochlea have relied studying sources. This study evaluates three cochlear tissue digestion and sEV (CDsEV) isolation methods, first proposes that optimal approach for isolating CDsEVs using collagenase D DNase І combined with...
MicroRNAs serve an important role in the development of several diseases. Numerous genes regulate skeletal muscle differentiation C2C12 myoblasts. The miR‑760 rheumatoid arthritis (RA) has not been reported, to best our knowledge. Therefore, aim present study was examine regulating proliferation RA. Potential functionally involved tarsal joint a collagen‑induced RA model were identified using Gene Expression Omnibus. Reverse transcription‑quantitative PCR and western blot analyses performed...
With the widespread application of monitoring technology and network storage technology, there are some privacy issues in process public service advertising visual design pushing works. Researching protection method is great significance to protecting data security designers personal other citizens. This paper proposes a digital watermark work push method, conducts experiment study on design. The used provide an innovative solution for protection. shows that evaluation score 11.05% higher...
ABSTRACT Sensorineural hearing loss is mainly caused by damage to hair cells (HC), which cannot be regenerated spontaneously in adult mammals once damaged. Cochlear Lgr5 + progenitors are characterised HC regeneration capacity neonatal mice, and we previously screened several new genes that might induce from progenitors. Net1 , a guanine nucleotide exchange factor, one of the particularly active cancer involved cell proliferation differentiation. Here, explore vivo roles regeneration,...
Utricle is an important vestibular sensory organ for maintaining balance. 3,3′-iminodipropionitrile (IDPN), a prototype nitrile toxin, has been reported to be neurotoxic and vestibulotoxic, can used establish in vivo damage model of dysfunction. However, the mechanism utricular HCs caused by IDPN unclear. Here, we first studied mice balance behavior utricle model, found that injection cause dysfunction damage, which more pronounced than neomycin model. Then RNA-seq characterize transcriptome...
As the number of joint arthroplasty and internal fixation surgeries continues to rise, infection involving orthopaedic surgical implants is a devastating complication. The prospect increasing burden these its tremendous impact on patients, health institutions, society significant public concern. Biofilm formation essential characteristic infections. success rate treatment biofilm infections such as antibiotic debridement lower than what excepted. Due recognized difficulty in eradicating...