A5056348970- Congenital heart defects research
- Dietary Effects on Health
- Glycogen Storage Diseases and Myoclonus
- Diabetes and associated disorders
- Bone health and osteoporosis research
- Neonatal Respiratory Health Research
- Pituitary Gland Disorders and Treatments
- Cancer Cells and Metastasis
- Adipokines, Inflammation, and Metabolic Diseases
- Signaling Pathways in Disease
- Diabetes Treatment and Management
- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- Acupuncture Treatment Research Studies
- RNA modifications and cancer
- Circadian rhythm and melatonin
- Diabetes Management and Research
- Sexual Differentiation and Disorders
- Reconstructive Surgery and Microvascular Techniques
- Metabolism, Diabetes, and Cancer
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Bone and Joint Diseases
- Bladder and Urothelial Cancer Treatments
- Sexual function and dysfunction studies
- Sleep and Wakefulness Research
South China University of Technology
2022-2024
Peking University
2024
National Clinical Research Center for Digestive Diseases
2024
Guangxi University
2024
Guangxi University of Chinese Medicine
2024
Southern Medical University
2006-2022
China International Science and Technology Cooperation
2019
Children's Hospital of Chongqing Medical University
2019
Chongqing Medical University
2019
Objective. To investigate the effect of dapagliflozin (DAPA) on cardiac hypertrophy induced by type 2 diabetes mellitus (T2DM) and its mechanism. Methods. SD rats with T2DM were divided into a group ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>n</mi> <mo>=</mo> <mn>6</mn> </math> ) DAPA id="M2"> ). They were, respectively, fed same amount normal saline 1 mg/kg DAPA. The control id="M3"> was also saline. hearts tested application echocardiography hemodynamics. Subsequently,...
This study investigated the association of capillary blood glucose (CBG)-assessed time in range (TIR) (3.9-10.0 mmol/L) with insulin sensitivity and islet β-cell function.We recruited 455 patients type 2 diabetes mellitus. Seven-point glucose-profile data (pre- 120 min post-main meals, bedtime) were collected over three consecutive days. Plasma serum concentrations measured at 0, 60, after a 100 g standard steamed bread meal test. The homeostasis model assessment resistance (HOMA-IR) Matsuda...
<title>Abstract</title> Background 18p deletion (18p-) syndrome is a rare chromosomal abnormality with wide range of phenotypes. Its main clinical features are short stature, intellectual disability, and facial dysmorphism, which rarely accompanied by autoimmune thyroid disease (ATD) or pituitary abnormalities. Herein, we report the first Chinese patient de novo who presented ATD. Case presentation: A 24-year-old female severe ptosis, hypothyroidism associated Hashimoto’s thyroiditis,...
Abstract Background Vascularized bone grafting (VBG) is preferred for mandibular reconstruction post‐tumor ablation. Although various bone‐free flaps are used, their application compromised by limitations including insufficient volume and poor shape. Here, we report using axial split‐step osteotomy with an iliac crest‐free flap. Methods Over December 2018–November 2020, 12 patients underwent via split a free iliac‐crest Results The preoperative length was 5.7–9.5 mm (median, 7.5 cm); the...
ObjectiveTo evaluate two osteoporosis screening tools, the self-assessment tool for Asians (OSTA) and Chinese (OSTC), in postmenopausal women with type 2 diabetes mellitus (T2DM).MethodsThis retrospective study enrolled female patients T2DM. Bone mineral density at lumbar spine (L1–4) left femoral neck was measured using dual-energy X-ray absorptiometry (DXA). The OSTA OSTC scores were calculated compared bone anatomical sites.ResultsA total of 404 T2DM this study. detection rates (L1–L4) by...
目的建立造血干细胞特异性Hdac3条件性敲除小鼠模型，探讨Hdac3基因对小鼠造血发育的影响。 方法Hdac3fl/fl小鼠与Mx1-Cre小鼠杂交获得Hdac3fl/fl Mx1-Cre小鼠，PCR鉴定小鼠基因型。连续注射poly(I:C)，诱导Cre表达，得到造血干细胞Hdac3敲除鼠Hdac3fl/flMx1-Cre+(CKO)及对照组小鼠Hdac3+/+Mx1-Cre+(WT)，Q-PCR分析Hdac3 mRNA表达水平。流式细胞术检测小鼠外周血淋巴细胞数量及比例。HE染色观察小鼠胸腺、脾脏形态学改变。流式细胞术检测小鼠外周血CD3+、B220+细胞比例。克隆形成实验分析小鼠造血干/祖(LSK)细胞的分化能力。 结果成功建立造血干细胞Hdac3fl/flMx1-Cre+(CKO)小鼠模型。与对照组相比，CKO小鼠外周血淋巴细胞绝对数量(P 结论造血干细胞中Hdac3基因促进造血干细胞向淋巴细胞分化。