A5100654093- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Oral microbiology and periodontitis research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Dental Trauma and Treatments
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Immune cells in cancer
- Mycobacterium research and diagnosis
- Antimicrobial Peptides and Activities
- Probiotics and Fermented Foods
- Craniofacial Disorders and Treatments
- Traditional Chinese Medicine Studies
- Autophagy in Disease and Therapy
- Periodontal Regeneration and Treatments
- Hematopoietic Stem Cell Transplantation
- S100 Proteins and Annexins
- Bone fractures and treatments
- Wound Healing and Treatments
- Bone and Dental Protein Studies
- Dental Erosion and Treatment
- Cancer Cells and Metastasis
- Luminescence and Fluorescent Materials
Air Force Medical University
2021-2025
Xinjiang Medical University
2024
Xinjiang University
2024
Sichuan Agricultural University
2023
Dalian Medical University
2023
Extracellular vesicles (EVs) derived from living cells play important roles in donor cell-induced recipient tissue regeneration. Although numerous studies have found that undergo apoptosis after implantation an ischemic-hypoxic environment, the played by EVs released apoptotic are largely unknown. In this study, we obtained (apoVs) human deciduous pulp stem and explored their effects on dental regeneration process. Our work showed apoVs were ingested endothelial (ECs) elevated expression of...
Abstract Objectives Pulp regeneration brings big challenges for clinicians, and vascularization is considered as its determining factor. We previously accomplished pulp with autologous stem cells from deciduous teeth (SHED) aggregates implantation in teenager patients, however, the underlying mechanism needs to be clarified regenerating adults. Serving an important effector of mesenchymal (MSCs), exosomes have been reported promote angiogenesis tissue effectively. Here, we aimed investigate...
Inflammation plays a crucial role in triggering regeneration, while inadequate or chronic inflammation hinders the regenerative process, resulting refractory wounds. Inspired by ideal regeneration mode lower vertebrates and human oral mucosa, realigning dysregulated to heightened acute response provides promising option for wound therapy. Neutrophils play important roles initiation resolution. Here, hybrid biomaterial is used stimulate transiently inflammatory responses precise tempospatial...
Abstract The interplay between bacteria and their host influences the homeostasis of human immune microenvironment, this reciprocal interaction also affects process tissue damage repair. A variety immunomodulatory commensal reside in body, capable delivering membrane vesicles (MVs) to cells regulate local microenvironment. This research revealed, for initial time, significant enhancement mucosal cutaneous wound healing by MVs secreted Lactobacillus reuteri (RMVs) through modulation...
Harnessing developmental processes for tissue engineering represents a promising yet challenging approach to regenerative medicine. Tooth avulsion is among the most serious traumatic dental injuries, whereas functional tooth regeneration remains uncertain. Here, we established strategy using decellularized matrix (DTM) combined with human pulp stem cell (hDPSC) aggregates simulate an odontogenesis-related microenvironment. The bioengineered teeth reconstructed by this regenerated...
Healthy aging is a common goal for humanity and society, one key to achieving it the rejuvenation of senescent resident stem cells empowerment organ regeneration. However, mechanistic understandings cell senescence potential strategies counteract remain elusive. Here, we reveal that bone microenvironment impairs Golgi apparatus thus diminishing mesenchymal (MSC) function Interestingly, replenishment aggregates-derived extracellular vesicles (CA-EVs) rescues dysfunction empowers MSCs through...
Harnessing the developmental events of mesenchymal condensation to direct postnatal dental stem cell aggregation represents a cutting-edge and promising approach tooth regeneration. Tooth avulsion is among most prevalent serious injuries, odontogenic aggregates assembled by cells from human exfoliated deciduous teeth (SHED) have proven effective in revitalizing avulsed after replantation clinical trial. However, whether how SHED (SA) communicate with recipient components promote synergistic...
The pits and fissures of teeth have high caries susceptibility, sealing these areas is considered as an effective method to prevent caries. However, long-term prophylaxis cannot be maintained because the negative effects derived from technical sensitivity disadvantages materials. Herein, a new strategy proposed occlude fossae by amyloid-mediated biomimetic remineralization. In contrast conventional inward blocking outside fossae, mineralization delivers amyloid-like protein nanofilm into...
Early orthodontic correction of skeletal malocclusion takes advantage mechanical force to stimulate unclosed suture remodeling and promote bone reconstruction; however, the underlying mechanisms remain largely unclear. Gli1+ cells in maxillofacial sutures have been shown participate development damage repair. Nevertheless, it remains be investigated whether these force-induced during treatment malocclusion. In this study, rapid maxillary expansion (RME) mouse models stretch loading cell were...
Abstract Background The emergence of multidrug resistance among enterococci makes effective treatment enterococcal infections more challenging. Giant pandas ( Ailuropoda melanoleuca ) are vulnerable to oral trauma and lesions as they feast on bamboo. Enterococci may contaminate such cause infection necessitating with antibiotics. However, few studies have focused the virulence drug oral-derived enterococci, including Enterococcus faecium , in giant pandas. In this study, we analyzed...
Cleidocranial dysplasia (CCD) is an autosomal-dominant, heritable skeletal and dental disease, involving hypoplastic clavicles, defective ossification of the anterior fontanelle, dentin enamel hypoplasia, supernumerary teeth, which can seriously affect oral mental health patients. Amyloid-like protein aggregation, established by lysozyme conjugated with polyethylene glycol (Lyso-PEG), forms a mineralized nanofilm layer on healthy surface. However, whether it form remineralization in tissues...
<title>Abstract</title> Periodontitis is a prevalent and progressive detrimental disease which characterized by chronic inflammation, the immunopathological mechanisms being not yet fully understood. Mesenchymal stem cells (MSCs) play crucial roles as immunoregulators maintain tissue homeostasis regeneration, but their <italic>in vivo</italic> function in immunopathology periodontal deterioration still unclear. Here, we utilized multiple transgenic mouse models to specifically mark, ablate...