A5003924296- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Neuroscience and Neuropharmacology Research
- Soft Robotics and Applications
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Cell Image Analysis Techniques
- Viral Infections and Immunology Research
- Plant Molecular Biology Research
- Ferroptosis and cancer prognosis
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Surgical Simulation and Training
- Folate and B Vitamins Research
- Atherosclerosis and Cardiovascular Diseases
- Railway Engineering and Dynamics
- Mechanical Engineering and Vibrations Research
- CRISPR and Genetic Engineering
- bioluminescence and chemiluminescence research
- Cancer-related gene regulation
- Sleep and Wakefulness Research
- Vehicle Dynamics and Control Systems
China Pharmaceutical University
2025
Hunan University
2023-2024
Washington University in St. Louis
2024
Beijing Shijitan Hospital
2022
Capital Medical University
2022
Johns Hopkins University
2021-2022
Zhengzhou University
2020-2022
Northwest A&F University
2021-2022
Zhengzhou People's Hospital
2022
National University of Singapore
2020-2021
Abstract Locus coeruleus (LC)-derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit connectivity, but the underlying synapse-level mechanisms are elusive. Here, we show that NE remodeling of synaptic function is independent from its binding on neuronal receptors. Instead, astrocytic adrenergic receptors Ca 2+ dynamics fully gate effect synapses as astrocyte-specific deletion three astrocyte-silencing approaches all render...
Acute myeloid leukemia (AML) is a hematologic malignancy with increased lethality. We focused on elucidating the role of Neratinib, tyrosine kinase inhibitor, in progression AML and identify potential mechanisms. Upon treatment autophagy suppressor 3-methyladenine (3-MA) ferroptosis stimulator Erastin, viability proliferation HL-60 cells were evaluated by cell counting kit-8 5-Ethynyl-20-Deoxyuridine staining assays. A flow cytometer was to observe cycle apoptosis. Production reactive oxygen...
Calcium imaging has become a popular way to probe astrocyte activity, but few analysis methods holistically capture discrete calcium signals that occur across the domain. Here, we introduce STARDUST, pipeline for Spatio-Temporal Analysis of Regional Dynamics & Unbiased Sorting Transients from fluorescence recordings astrocytes, and provide step-by-step guidelines. STARDUST yields time-series data-defined regions activity performs systematic signal detection feature extraction, enabling...
Abstract Background Giant cell arteritis (GCA) is a prevalent artery and strongly correlated with age. The role of CD4+ Memory T cells in giant has not been elucidated. Method Through single-cell analysis, we focused on the arteritis. eQTL analysis mendelian randomization identified significant genes which have causal effect risk. were subsequently divided into gene-positive gene-negative groups, then further was conducted. Mendelian plasma proteins, blood-urine biomarkers metabolites also...
Background: Lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSCC) are two of the most common subtypes non-small cancer (NSCLC), with high mortality rates rising incidence worldwide. Ferroptosis is a mode programmed death caused by lipid peroxidation, accumulation reactive oxygen species, dependent on iron. The recent discovery ferroptosis has provided new insights into tumor development, clinical relevance for therapy being increasingly appreciated. However, its role in NSCLC...
This study aimed to investigate the virome diversity of SLE disease and association between viral infections disease.
The ability to regulate endogenous gene expression is critical in biological research. Existing technologies, such as RNA interference, zinc-finger regulators, transcription-activator-like effectors, and CRISPR-mediated regulation, though proved be competent significantly altering levels, do not provide a quantitative adjustment of regulation effect. As solution this problem, we place interference under the control blue light: while dCas9 protein constitutively expressed, guide transcription...
Prostate biopsy procedures as a gold standard for early screening of prostate cancer often suffer from multipass needle perforations to irrelevant perineal tissue, high complication risk, and time consumption. To address these challenges, this article proposes transurethral robot that can deliver flexible inside the different angles thus obtain tissue samples multiple locations. Emphasis is on design validation with detailed introduction working principle, mechanism modeling, function...
The TRS-mediated discontinuous transcription process is a hallmark of Arteriviruses. Precise assessment the intricate subgenomic RNA (sg mRNA) populations required to understand kinetics viral transcription. It difficult reconstruct and comprehensively quantify splicing events using short-read sequencing, making identification transcription-regulatory sequences (TRS) particularly problematic. Here, we applied long-read direct sequencing characterize recombined molecules produced in porcine...
Cell growth is well defined for late (postembryonic) stages of development, but evidence early (embryonic) cell during postmitotic morphogenesis limited. Here, we report as a key characteristic tubulogenesis in the Drosophila embryonic salivary gland (SG) and trachea. A BTB/POZ domain nuclear factor, Ribbon (Rib), mediates this growth. Rib binds transcription start site nearly every SG-expressed ribosomal protein gene (RPG) required full expression all RPGs tested. binding to RPG promoters...
Abstract Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease. Many viruses have been reported to be associated with SLE, but the diversity of virome in SLE and mechanisms underlying interactions between viral infection are still unclear. This study identified ten human virus species from 826 RNA-Seq samples blood 688 patients 138 healthy controls. were found higher positive rates than controls, although abundances low comparable both Analysis antiviral...
Abstract Background Activating transcription factor-2 (ATF2) is a member of the basic leucine zipper family DNA-binding proteins, which exhibits both oncogenic and tumor suppression activity in different tumors. However, molecular mechanism its dual function cancer chemotherapy especially gastric has still not been elucidated. Methods The protein expression location ATF2 tissues was detected with immunohistochemistry assay, clinical significance analyzed using TCGA GEO database. activation...
Abstract The ongoing Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) pandemic has acutely highlighted the need to identify new treatment strategies for viral infections. Here we present a pivotal molecular mechanism of protein translation that relies on mitochondrial machinery. We found rare codons such as Leu-TTA are highly enriched in many viruses, including SARS-CoV-2, and these essential regulation expression. SARS-CoV-2 controls its spike gene by hijacking host mitochondria...
ABSTRACT Cell growth is well defined for the late (post-embryonic) stages of development, but evidence early (embryonic) cell during post-mitotic morphogenesis quite limited. Here, we identify as a key characteristic tubulogenesis in Drosophila embryonic salivary gland (SG). A BTB/POZ domain nuclear factor, Ribbon (Rib), mediates this growth. Rib binds transcription start site nearly every SG-expressed ribosomal protein gene (RPG) and required full expression all RPGs tested. binding to RPG...