A5100390956- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Cancer and Skin Lesions
- Proteoglycans and glycosaminoglycans research
- Skin and Cellular Biology Research
- Periodontal Regeneration and Treatments
- Infectious Diseases and Mycology
- Developmental Biology and Gene Regulation
- Tissue Engineering and Regenerative Medicine
- Liver physiology and pathology
- Drug Transport and Resistance Mechanisms
- Infectious Diseases and Tuberculosis
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Angiogenesis and VEGF in Cancer
- Moyamoya disease diagnosis and treatment
- Silk-based biomaterials and applications
- Cancer-related gene regulation
- IgG4-Related and Inflammatory Diseases
- Vascular Tumors and Angiosarcomas
- MicroRNA in disease regulation
- Hedgehog Signaling Pathway Studies
- Bone and Dental Protein Studies
Sichuan University
2024
Shenyang Anorectal Hospital
2024
Air Force Medical University
2013-2023
National Clinical Research Center for Digestive Diseases
2020-2023
Wuhan University
2023
Stomatology Hospital
2018-2023
Guangzhou Medical University
2023
Shanghai Ninth People's Hospital
2018-2022
Shanghai Jiao Tong University
2018-2022
Affiliated Eye Hospital of Wenzhou Medical College
2022
Slow vascularization rate is considered one of the main drawbacks scaffolds used in wound healing. Several efforts, including cellular and acellular technologies, have been made to induce vascular growth scaffolds. However, thus far, there no established technology for inducing growth. The aim this study was promote capacities by seeding adipose-derived stem cells (ADSCs) on them compare different seeded with ADSCs. Two kinds extracellular matrix (small intestinal submucosa [SIS] dermal...
Liver sinusoidal endothelial cells (LSECs) critically regulate liver homeostasis and diseases through angiocrine factors. Notch is critical in (ECs). In the current study, signaling was activated by inducible EC‐specific expression of intracellular domain (NIC). We found that activation damaged homeostasis. resulted decreased fenestration increased basement membrane, a gene profile with LSEC‐associated genes continuous EC‐associated genes, suggesting LSEC dedifferentiation. Consistently,...
Abstract Two crucial growth factors, FGF2 and TGFβ 1 , were investigated in this study to determine their inductive effects on the odontoblastic differentiation of human dental pulp stem cells (DPSCs) vitro . DPSCs isolated by immunomagnetic bead selection using STRO‐1 antibody, then co‐cultured respectively with FGF2, + The results showed that can exert a significant effect cell proliferation, while or initiate an odontoblast‐like DPSCs. Moreover, synergistically upregulate DPSCs, as...
Background Endothelial cells ( EC s) form blood vessels through angiogenesis that is regulated by coordination of vascular endothelial growth factor VEGF ), Notch, transforming β, and other signals, but the detailed molecular mechanisms remain unclear. Methods Results Small RNA sequencing initially identified miR‐342‐5p as a novel downstream molecule Notch signaling in s. Reporter assay, quantitative reverse transcription polymerase chain reaction Western blot analysis indicated targeted...
Ocular neovascularization is a comprehensive process involved in retinal vascular development and several blinding diseases such as age-related macular degeneration retinopathy of prematurity, with endothelial growth factor (VEGF) regarded the master regulator. However, qualified effect anti-VEGF therapy reveals that underlying mechanisms are still not clearly identified. To initialize angiogenesis, cells undergo phenotype switching to generate highly migratory invasive cells. This shares...
Many types of skin substitutes have been constructed using exogenous materials. Angiogenesis is an important factor for tissue-engineered constructs. In this study, we a scaffold-free bilayered containing capillary network. First, cocultured dermal fibroblasts with microvascular endothelial cells at ratio 2 : 1. A fibrous sheet was formed by the interactions between and cells, capillary-like structures were observed after 20 days coculture. Epithelial then seeded on to assemble tissue. HE...
Our aim was to establish a "nomogram" model forecast the overall survival (OS) and cancer-specific (CSS) of oral squamous cell carcinoma (OSCC) patients. The clinicopathological data for 10,533 OSCC patients were collected from Surveillance, Epidemiology End Results (SEER) database. We used credible random split-sample method divide into two cohorts: 7046 in modeling cohort 3487 external validation (split-ratio = 2:1). median follow-up period 32 months (1-119 months). developed nomograms...
The spread of antibiotic resistant bacteria (ARB) and resistance genes (ARGs) in hospital wastewater poses a great threat to public health, treatment plants (WWTPs) play an important role reducing the levels ARB ARGs. In this study, high-throughput metagenomic sequencing was used analyze bacterial community composition ARGs two hospitals exposed different use conditions (an eye specialty general hospital) before after treatment. results showed that there were various potential pathogenic...
Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory oral mucosal disease of unknown etiology, and liquefaction degeneration in the basal keratinocytes one specific histological changes. However, understanding still very limited, how does it affect prognosis LP largely unknown. Therefore, objective this study was to clarify intrinsic change behind evaluate effect OLP-typical cytokine, IFN-γ, on these changes.Biopsies were collected from patients with OLP; immunochemistry...
Abstract Nanohydroxyapatite (nHAP) has broad applications because of its nanoscopical dimension, large specific surface area, biocompatibility, and low cytotoxicity. Researchers recently discovered that nHAP synthesized in vitro inhibits the growth different types tumor cells. with potent drug adsorption loading capacity potential diagnosis treatment. Because local tumors areas metastasis also produce pathological vivo to promote progression invasion, role tumorigenesis development is...
Due to its essential roles in angiogenesis, Notch pathway has emerged as an attractive target for the treatment of pathologic angiogenesis. Although both activation and blockage signal can impede may be more promising because it was shown that long-term resulted vessel neoplasm. However, vivo deliverable ligand with highly efficient Notch-activating capacity not been developed. Among all ligands, Delta-like4 (Dll4) is specifically involved In this study, we generated a novel soluble hD4R,...
Background Multidrug resistance-related protein 1 (MRP1/ABCC1) and multidrug resistance (MDR1/P-glycoprotein/ABCB1) are both membrane-bound drug transporters. In contrast to MDR1, MRP1 also transports glutathione (GSH) drugs conjugated GSH. Due its extraordinary transport properties, MRP1/ABCC1 contributes several physiological functions pathophysiological incidents. We previously found that nuclear translocation of multidrug-resistance (MDR) mucoepidermoid carcinoma (MEC). The present study...
MR (mineralocorticoid receptor) antagonists have been demonstrated to provide beneficial effects on preventing atrial fibrosis. However, the underlying cellular and molecular mechanisms remain unclear. We aim determine role of osteoblast in fibrosis explore mechanism. Using knockout mouse combination with mutant TGF (transforming growth factor)-β1 transgenic mouse, we that deficiency osteoblasts significantly attenuated Mechanistically, directly regulated expression OCN (osteocalcin)...
Objectives Multidrug resistance-related protein 1 (MRP1) overexpression is a well acknowledged predictor of poor response to chemotherapy, but MRP1 also correlated better prognosis in some reports, especially for patients not pretreated with chemotherapy. In our previous study, we found nuclear translocation mucoepidermoid carcinoma (MEC) the first time. The purpose this study was further investigate function MEC. Materials and Methods Human MEC tissue samples 125 were selected stained using...
Racial variation exists in the incidence of orofacial granulomatosis (OFG). The epidemiology and clinical characteristics OFG Asian countries are poorly described.To describe epidemiologic features China from data collected on chronic odontogenic infection studied actual practice regarding long-term outcome patients receiving different treatments.Data demographics, medical history, infection, extent disease were collected, outcomes after end treatments evaluated.Of 165 patients, 118 (71.5%;...
Human cancers induce a chaotic, dysfunctional vasculature that promotes tumor growth and dampens most current therapies, but the underlying mechanism has been unclear. Here we show SPEN (split end), transcription repressor, coordinates ribosome RNA (rRNA) synthesis in endothelial cells (ECs) is required for physiological angiogenesis. deficiency attenuated EC proliferation blunted retinal angiogenesis, which was attributed to p53 activation. Furthermore, knockdown activated by upregulating...