A5088782356- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Hepatitis Viruses Studies and Epidemiology
- Protein purification and stability
- Pancreatitis Pathology and Treatment
- Folate and B Vitamins Research
- Viral gastroenteritis research and epidemiology
- RNA modifications and cancer
- Blood Pressure and Hypertension Studies
- Plant Toxicity and Pharmacological Properties
- Diet, Metabolism, and Disease
- Metabolism and Genetic Disorders
- Alcohol Consumption and Health Effects
- Venous Thromboembolism Diagnosis and Management
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Helicobacter pylori-related gastroenterology studies
- Lipid metabolism and disorders
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
Beijing YouAn Hospital
2018-2024
Capital Medical University
2017-2024
Beijing Fengtai Hospital
2017
Abstract Background and Aim To identify individuals with metabolic dysfunction‐associated steatohepatitis (MASH) or “at‐risk” MASH among patients steatotic liver disease (MASLD), three noninvasive models are available satisfactory efficiency, which include magnetic resonance imaging [MRI]‐ AST (MAST), FibroScan‐AST (FAST score), elastography [MRE] plus FIB‐4 (MEFIB). We aimed to evaluate the most accurate approach for diagnosing MASH. Methods included 108 biopsy‐proven MASLD who underwent...
Background Recent studies indicated that the neutrophil percentage-to-albumin ratio (NPAR) was a predictor of mortality in several diseases. There has been no evidence to prove predictive function NPAR patients with liver cirrhosis. Therefore, this study aimed investigate association between and clinical outcomes cirrhotic patients. Methods We retrospectively recruited hospitalized decompensated from tertiary grade-A hospital. Patients malignancy or severe cardiac, respiratory kidney...
Several studies have identified that three SAMM50 polymorphisms (rs2073082, rs738491, rs3761472) are associated with an increased risk of non-alcoholic fatty liver disease (NAFLD). However, the clinical significance SNP in relation to NAFLD remains largely unknown. Therefore, we conducted a study and SNP-SNP interaction analysis further elucidate effect on progression elderly.A total 1053 patients over age 65 years were recruited. Liver fat fibrosis detected by abdominal ultrasound or...
Cell death markers, M65 and M30, have been suggested to be sensitive markers of liver inflammation fibrosis in nonalcoholic fatty disease chronic hepatitis C. Our aim was investigate whether these were useful diagnosing B (CHB). We examined 186 patients with CHB; 18 sex- age-matched healthy subjects controls. The blood samples collected from CHB within 1 week before or after biopsy. According METAVIR score system, graded A0 A3, F0 F4. Serum M30 levels parallel the grades inflammation. M65,...
Acute-on-chronic liver failure (ACLF) is divided into three types according to the underlying disease: non-cirrhosis (type A), compensated cirrhosis B) and decompensated C). However, whether chronic diseases impact ACLF prognosis not clear. The present study aimed compare characteristics outcomes of type A B hepatitis virus (HBV)-ACLF patients.According European Association for Study Liver-Chronic Liver Failure (EASL-CLIF) diagnostic criteria, 86 HBV-ACLF 71 were prospectively enrolled....
Regucalcin is a soluble protein that principally expressed in hepatocytes. Studies of regucalcin have mainly been conducted animals due to lack commercially available kits. We aimed develop an enzyme-linked immunosorbent assay (ELISA) quantify serum patients with hepatitis B virus (HBV)-related disease. High-titer monoclonal antibodies and polyclonal antibody were produced, double-antibody sandwich ELISA method was established, determined 47 chronic (CHB) patients, 91 HBV-related...
Objective Hepatic sinusoidal endothelial injury is a prominent characteristic of liver cirrhosis. We determined plasma soluble thrombomodulin (sTM) levels in cirrhosis patients to evaluate the relationship between vascular and long-term prognosis. Methods A prospective single-center study was performed. The participants were followed up for every 6 months or until death transplantation. chemiluminescent enzyme immunoassay used establish baseline sTM. Results Among 219 with decompensated...
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Our recent study showed a high rate of HBsAg clearance in inactive carriers (IHCs) treated with pegylated IFN (PEG-IFN). To better understand the immune-mediated component clearance, this investigated role serum immunoglobulin G (IgG) and its subclasses predicting IHCs PEG-IFN therapy.In study, received for 96 weeks. Subjects who achieved were considered responders (R group), those whom was not cleared non-responders (NR group). The HBsAg, ALT, lgG subtypes (lgG1, IgG2, IgG3, lgG4) tested at...
Abstract Background and aim Pyrrolizidine alkaloids (PA) induced hepatic sinusoidal obstruction syndrome (HSOS) occurred worldwide the mortality rate remained high because there were no specific therapies. Defibrotide was effective for HSOS following hematopoietic stem cell transplantation. But pathogenesis of two types not equivalent. The purpose this study to see if defibrotide also in PA rat HSOS. Methods First we improved model by using higher dose (230 mg/kg) monocrotaline (a kind PA)...
Objective:To systematically review the association of PNPLA3 rs738409 G/C gene polymorphism with non-alcoholic fatty liver disease(NAFLD) in children. Design: Systematic and meta-analysis. Data sources study selection: We searched MEDLINE, PubMed, EMBASE, CENTRAL databases from inception to May 2019. Case-control studies assessing relationship between disease children were selected according inclusion exclusion criteria. extraction analyses: First author's surname, publication year, country,...
Abstract Aim To further explore the association between Transmembrane 6 superfamily member 2 (TM6SF2) rs58542926 T/C gene polymorphism and hepatic fibrosis. Materials Methods In this study MEDLINE, PubMed, EMBASE, CENTRAL databases were queried from inception to March 21, 2020. According inclusion exclusion criteria, case-control studies assessing relationship TM6SF2 significant liver fibrosis selected. NOS scale was used evaluate included literature. Stata 12.0 software for data analysis....
Objective The markers of cell death, M65 and M30, have been suggested to be sensitive liver fibrosis in nonalcoholic fatty disease chronic hepatitis C. Only few studies were carried out on B (CHB) the results inconsistent. Our aim was investigate if these showed difference different stages CHB patients. Methods We examined 186 patients with CHB. Eighteen gender age matched healthy subjects used as controls. Blood samples collected from one week before or after biopsy. Liver...
Objective To analyze the pathogenesis and clinical characteristics of drug-induced liver injury (DILI) to explore corresponding nursing interventions. Methods From January 2011 December 2013, a total 84 patients with chronic in Beijing You'an Hospital were recruited by convenience sampling method according diagnostic criteria Guidelines for Management Drug-Induced Liver Injury. The demographic characteristics, possible drugs inputted into Epidata management database analyzed using...