A5100751921- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Aquaculture disease management and microbiota
- Hepatitis C virus research
- Liver physiology and pathology
- Nonmelanoma Skin Cancer Studies
- Drug-Induced Hepatotoxicity and Protection
- Retinal Diseases and Treatments
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer and Skin Lesions
- Diabetic Foot Ulcer Assessment and Management
- Retinal Imaging and Analysis
- Hematopoietic Stem Cell Transplantation
- Cardiovascular Health and Risk Factors
- Diverse Scientific Research in Ukraine
- Glutathione Transferases and Polymorphisms
- Renal cell carcinoma treatment
- Chronic Disease Management Strategies
City of Hope
2024-2025
Xiamen University
2025
Huazhong University of Science and Technology
2025
Peking University
2019-2024
Peking University People's Hospital
2022-2024
Dalian Ocean University
2023-2024
Beijing YouAn Hospital
2024
Capital Medical University
2024
City Of Hope National Medical Center
2023
Guang’anmen Hospital
2020-2021
Hepatitis B virus (HBV) is a hepatotropic causing hepatitis, cirrhosis and hepatocellular carcinoma (HCC). The methylation status of the HBV DNA in its different forms can potentially provide insight into pathogenesis HBV-related liver diseases, including HCC, however this unclear. goal study to obtain comprehensive profiles three putative CpG islands infected livers, with respect disease progression. extent these was first assessed using bisulfite PCR sequencing small set tissue samples,...
Terminally differentiated cells can be generated by lineage reprogramming, which is, however, hindered incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy mimicking the natural regeneration route, permits generating expandable hepatic progenitor functionally competent human hepatocytes. Fibroblasts were first induced into progenitor-like (hHPLCs), could robustly expand in vitro efficiently engraft vivo....
Abstract Background: Clonal hematopoiesis of indeterminate potential (CHIP) and diabetes mellitus (DM) are aging-related phenomena associated with risk premature mortality in the general population. CHIP is highly prevalent patients undergoing HCT, but its association DM survival after HCT unknown. Methods: This single-center study included 1,931 consecutive who underwent autologous for lymphoma or myeloma between 2010-2016. Demographic clinical data were abstracted from medical record....
Hypermethylation of the glutathione S-transferase π 1 (GSTP1) gene promoter region has been reported to be a potential biomarker distinguish hepatocellular carcinoma (HCC) from other liver diseases. However, reports regarding how specific marker it is have ranged 100% 0%. We hypothesized that, large extent, variation specificity depends on location CpG sites analyzed. To test this hypothesis, we compared methylation status GSTP1 DNA isolated HCC, cirrhosis, hepatitis, and normal tissues by...
No final conclusion has yet been reached on characteristics of postoperative pain and pain-related factors after video-assisted thoracoscopic surgery (VATS). This study was designed to explore features acute severe chronic post-surgical (CPSP), the VATS.Data patients who underwent VATS for lung cancer in Cancer Hospital, Chinese Academy Medical Sciences between March 2017 January 2019 were reviewed this retrospective study. A numerical rating scale (NRS) used evaluating intensity including...
Abstract The intake of high dietary fat has been correlated with the progression age‐related macular degeneration (AMD), affecting function retinal pigment epithelium through oxidative stress. A high‐fat diet (HFD) can lead to lipid metabolism disorders, excessive production circulating free fatty acids, and systemic inflammation by aggravating degree Deletion G‐protein‐coupled receptor (RGR‐d) identified in drusen. In this study, we investigated how RGR‐d exacerbates AMD‐like changes under...
Abstract Background To investigate ocular biological characteristics for myopic children with axial length (AL) reduction during orthokeratology (Ortho-K) treatment and provide clinical clues better myopia control effects. Methods Changes in parameters zone (TZ) 75 subjects who completed one-year Ortho-K were retrospectively reviewed. The divided into two groups according to AL change: the group (n = 37) elongation 38). Univariate multivariate regression analyses performed determine...
Objectives The purpose of this study was to investigate the performance ultrasound biomicroscopy (UBM) and high‐frequency (HFUS) in assessment extramammary Paget disease (EMPD) correlate imaging features with pathologic findings. Methods In retrospective study, we described from UBM HFUS based on 17 pathologically proven EMPD cases. for visualizing layer involvement by compared. Additionally, checked consistency between lesions images results. blood flow status lymph nodes were investigated...
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. The beta-catenin gene, CTNNB1, among the most frequently mutated in HCC tissues. However, mutational analysis tumors hampered by difficulty obtaining tissue samples using traditional biopsy. Here, we explored feasibility detecting tumor-derived CTNNB1 mutations cell-free DNA (cfDNA) extracted from urine patients. Using short amplicon qPCR assay targeting hotspot codons 32-37 (exon 3), detected 25% (18/73)...
Myopia is usually caused by excessive elongation of the eye during development. This condition common worldwide. In clinical practice, progression myopia commonly controlled through optical or drug measures, but specific mechanisms underlying these two treatments remain unclear. To verify whether effects on posterior-pole tissues are similar different, we studied a set transcriptional changes in chicken models.Chicks were divided into four groups, and they given intervention measures...
Chronic hepatitis B (CHB) is a global public health problem. Antiviral therapy the primary treatment. Studies have shown that combined of traditional Chinese medicine (TCM) and conventional antiviral drugs has better efficacy than for treatment CHB. YinQiSanHuang-antiviral decoction (YQSH) TCM compound preparation an effect on anti-hepatitis virus slowing progression B-related liver diseases. To evaluate safety YQSH with entecavir its preventive cirrhosis, we designed this randomized,...
There are only four sizes of implantable collamer lens (ICL) available for selection, which cannot completely fit all patients as a result the discontinuity ICL sizes. Sizing an optimal and predicting postoperative vault still unresolved problems. This study aimed to develop validate innovative data-level data-balancing machine learning-based models size vault.
AIM: To describe the distribution of ocular biometrics and to evaluate its associations with refractive error assess contribution from parameters among Chinese myopic children. METHODS: This cross-sectional study evaluated subjects aged 8-12y. Keratometry, biometry, cycloplegic autorefraction were performed on each subject. Spherical equivalent refraction (SER) assessed as a function age gender. The Pearson correlation analysis between SER was carried out. Multiple linear regression analyze...