In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is not clear, however, if directly insults the axon, soma, or both. The pathways that mediate pressure-induced death are poorly defined, and no molecules known be required. DBA/2J mice deficient in proapoptotic molecule BCL2-associated X protein (BAX) were used investigate roles of BAX-mediated glaucoma. Both Bax+/− Bax−/− protected from contrast, axonal degeneration was prevented either mice....

Abstract Background Glaucoma is a chronic neurodegenerative disease of the retina, characterized by degeneration axons in optic nerve and retinal ganglion cell apoptosis. DBA/2J inbred mice develop hereditary glaucoma are an important model system to study molecular mechanisms underlying this novel therapeutic interventions designed attenuate loss cells. Although genetics these well characterized, etiology its progression, particularly with respect degeneration, not. We have used two...

To evaluate the reproducibility of anterior chamber (AC) angle measurements obtained using segment optical coherence tomography (AS-OCT).Patients with suspected glaucoma and those glaucoma, ocular hypertension, or anatomically narrow angles were recruited from service at National University Hospital, Singapore. All subjects underwent imaging nasal, temporal, inferior AC an AS-OCT prototype under standardized dark light conditions. For short-term analysis, a single observer acquired two sets...

PURPOSE: To study the accuracy and repeatability of anterior, posterior, net corneal power measured by Fourier-domain optical coherence tomography (OCT). SETTING: Doheny Eye Institute, Los Angeles, California, USA. DESIGN: Cross-sectional study. METHODS: A OCT system (RTVue) was used to scan normal eyes, eyes after myopic laser in situ keratomileusis (LASIK), keratoconic eyes. After surfaces were delineated, calculated anterior posterior powers curve fitting over central 3.0 mm diameter...

PURPOSE: To evaluate the repeatability of Fourier-domain optical coherence tomography (OCT) pachymetric mapping and compare central corneal thickness (CCT) measurements by OCT, ultrasound pachymetry, scanning-slit tomography. SETTING: Doheny Eye Institute, University Southern California, Los Angeles, USA. METHODS: A OCT system was used to map in normal eyes with scans centered on vertex or pupil. Repeatability pericentral sectors assessed pooled standard deviation. The CCT were compared...

Light has been clinically utilized as a stimulation in medical treatment, such Low-level laser therapy and photodynamic therapy, which more widely accepted public. The penetration depth of the treatment light is important for precision safety control. issue highlighted biomedical optics field decades. However, quantitative research sparse even there are conflicts view on capability near-infrared into brain tissue. This study attempts to quantitatively revisit this by innovative...

To measure the correlation between subjective symptom score, conventional clinical tests, and Fourier-domain optical coherence tomography (FD-OCT) of lower tear meniscus parameters in patients with dry eye disease.Eighteen disease requiring medical therapy and/or punctal occlusion were recruited for this prospective, nonrandomized, observational case series. Severity symptoms was assessed using Indiana University Dry Eye Questionnaire 2002. Clinical assessments completed slit-lamp...

Purpose: To develop an intraocular lens (IOL) power calculation formula based on optical coherence tomography (OCT) that would not be biased by previous laser vision correction. Methods: Twenty-seven eyes of 27 cataract patients without prior correction who underwent phacoemulsification were included in the study. An biometer (IOLMaster, Carl Zeiss Meditec) measured anterior corneal curvature and axial eye length. A high-speed (2000 Hz) segment OCT prototype mapped thickness chamber depth...

Purpose.: The differential diagnosis of a patient presenting with anterior uveitis is broad and can present diagnostic challenge. In this study, we evaluate the characteristic findings inflammatory cells on optical coherence tomography (OCT) both in vitro vivo.

Abstract Background Implantable Collamer Lens (ICL) surgery has been proven to be a safe, effective, and predictable method for correcting myopia myopic astigmatism. However, predicting the vault ideal ICL size remains technically challenging. Despite growing use of artificial intelligence (AI) in ophthalmology, no AI studies have provided available choices different instruments combinations further predictions. This study aimed fill this gap predict post-operative appropriate utilizing...

PURPOSE: To study the architecture of clear corneal incisions for phacoemulsification cataract surgery using optical coherence tomography (OCT). SETTING: Doheny Eye Institute and Department Ophthalmology, Keck School Medicine University Southern California, Los Angeles, USA. METHODS: This prospective comprised 20 eyes patients 1 month after performed by 2 experienced surgeons. Temporal single-plane were made with 3.0 mm metal keratomes. Each eye was scanned before a prototype high-speed...

BACKGROUND AND OBJECTIVE: To examine the between-grader repeatability of height, depth, and cross-sectional area measurements lower tear meniscus, using a Fourier-domain optical coherence tomography (OCT) system. PATIENTS METHODS: A total 16 patients with dry eye had meniscus right imaged twice in rapid succession. The were measured by two masked graders computer calipers. variability, calculated pooled coefficient variation (CV%), assessed measurements. RESULTS: CV% was 12.1%, 15.7%, 19.5%...

Parkinson's disease (PD) is associated with structural alterations of the retina. However, it remains unknown whether these changes are present in PD mild cognitive impairment (MCI). The purpose study was to evaluate retinal microvasculature using optical coherence tomography angiography (OCTA) assess possible microvascular impairments and MCI.This included 83 eyes 45 patients 42 healthy controls. All subjects underwent complete neurological ophthalmological examinations before measurements....

New advances in anterior segment optical coherence tomography (OCT) technology development allow visualizing the chamber angle of eye with high speed and resolution. Fourier-domain (FD) OCT instruments working at 840 nm can reliably identify fine structures such as Schwalbe's line. This paper demonstrates quantitative assessment FD-OCT provides diagnostic cutoff values for occludable detection. is useful closure glaucoma diagnosis management. Moreover, a tool postsurgical evaluation patients.

Purpose. To quantify corneal epithelial thickness changes after myopic LASIK by OCT. Methods. Epithelial before and were measured a Fourier-domain OCT system. Average central (within 1 mm diameter) paracentral (5~6 compared. Correlation between change laser spherical equivalent setting was evaluated. An smoothing constant estimated based on mathematical model published previously. Results. Nineteen eyes from 11 subjects included in the study. Eyes had ranging -1.69 D to -6.75 equivalent. The...

Purpose: To examine whether alcohol drinking status and pattern are associated with self-reported visual impairment.Methods: We used data from the Behavioral Risk Factor Surveillance System, a state-based telephone health survey conducted by random-digit dialing among non-institutionalized US adults. The Visual Impairment Access to Eye Care module was implemented 42, 713 adults aged 50 years older in 2005 2006. impairment defined as any degree of difficulty experienced recognizing friend...

Keratoconus is a progressive disorder of the cornea and typically considered noninflammatory disease. However, increasing evidence indicates that immune disorders play an essential role in keratoconus progression, but immune-related etiology remains elusive. Here, we comprehensively utilized bioinformatics approaches experimental methods to explore potential immunoregulatory mechanism progression. Transcriptomics data containing two patient groups was derived from public dataset GSE151631....

Near-infrared spectroscopy (NIRS) has become widely accepted as a valuable tool for noninvasively monitoring hemodynamics clinical and diagnostic purposes. Baseline shift attracted great attention in the field, but there been little quantitative study on baseline removal. Here, we aimed to characteristics of an in-house-built portable medical NIRS device over long time (>3.5 h). We found that measured baselines all formed perfect polynomial functions phantom tests mimicking human bodies,...

Abstract Background To investigate ocular biological characteristics for myopic children with axial length (AL) reduction during orthokeratology (Ortho-K) treatment and provide clinical clues better myopia control effects. Methods Changes in parameters zone (TZ) 75 subjects who completed one-year Ortho-K were retrospectively reviewed. The divided into two groups according to AL change: the group (n = 37) elongation 38). Univariate multivariate regression analyses performed determine...

Purpose To evaluate the repeatability of Fourier domain optical coherence tomography (OCT) pachymetric mapping in patients with corneal opacities and to assess reliability OCT 830 nm wavelength as a measurement tool opaque corneas. Methods A system was used map thickness scars or dystrophy. retrospective study consecutive series conducted. The measured using pooled standard deviation repeated measurements. slit-scanning device provided for comparison. Results Seventeen eyes 12 (7 trauma 3...

With its sequential image acquisition, OCT-based corneal topography is often susceptible to measurement errors due eye motion. We have developed a novel algorithm detect motion and minimize impact on OCT maps. applied the correction topographic scans acquired using 70 kHz spectral-domain device. measurements were compared those from rotating Scheimpflug camera topographer. The provided 2-4 fold improvement in repeatability of agreement with standard Zernike-based mean power, cardinal...