A5016468479- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Ocular Surface and Contact Lens
- Retinal Development and Disorders
- Corneal Surgery and Treatments
- Retinal Diseases and Treatments
- Chemokine receptors and signaling
- DNA Repair Mechanisms
- Intraocular Surgery and Lenses
- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
- Ocular Diseases and Behçet’s Syndrome
- Ocular Oncology and Treatments
- Photoreceptor and optogenetics research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Retinal and Optic Conditions
- Glioma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Genomics and Chromatin Dynamics
- Photochromic and Fluorescence Chemistry
- CRISPR and Genetic Engineering
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
Sun Yat-sen University
2016-2025
Key Laboratory of Guangdong Province
2022-2024
Chinese Academy of Sciences
2011-2023
National Astronomical Observatories
2023
Zhongshan Ophthalmic Center, Sun Yat-sen University
2012-2020
National Natural Science Foundation of China
2019
Facilitated by the rapid progress of high-throughput sequencing technology, a large number long noncoding RNAs (lncRNAs) have been identified in mammalian transcriptomes over past few years. LncRNAs shown to play key roles various biological processes such as imprinting control, circuitry controlling pluripotency and differentiation, immune responses chromosome dynamics. Notably, growing lncRNAs implicated disease etiology. With increasing published lncRNA studies, experimental data on (e.g....
Purpose To evaluate a new regression-derived nomogram for high myopic astigmatism in small incision lenticule extraction (SMILE) surgery. Methods In this prospective study, data from 180 eyes with ranging −2.50 to −4.50 diopters (D) at 3 months after SMILE surgery were analyzed construct the astigmatic nomogram. Linear regression between target induced and flattening effect formula was derived as adjust treatment. The applied 112 −2.75 D. Subsequently, 143 (manifest refraction group) greater...
Tetramethylpyrazine (TMP) is one of the active ingredients extracted from Chinese herb Chuanxiong, which has been used to treat cerebrovascular and cardiovascular diseases, pulmonary diseases cancer. However, molecular mechanisms underlying actions TMP have not fully elucidated. In a previous study we showed that TMP-mediated glioma suppression neural protection involves inhibition CXCR4 expression. The SDF-1/CXCR4 axis plays fundamental role in many physiological pathological processes....
Abstract Exosomes derived from tumor cells play a key role in development. In the present study, we identified bioactivity of exosomes released WERI-Rb1 retinoblastoma angiogenesis, as well underlying mechanism, through biochemical methods and animal experiments. Our vitro data showed that could be engulfed by human vesicle endothelial (HUVECs), significantly promote cell viability induce an inflammatory response HUVECs increasing expression series related genes, such IL-1, IL-6, IL-8,...
Purpose: To compare the functional optical zone (FOZ) and visual quality after small-incision lenticule extraction (SMILE) femtosecond laser–assisted laser in situ keratomileusis (FS-LASIK) correcting high myopia. Methods: Ninety-two eyes of 46 myopic patients with same programmed (POZ) received SMILE one eye FS-LASIK contralateral eye. FOZ was calculated using a refractive power method. The decentration, outcomes, wavefront aberrations, contrast sensitivity, vision (QoV) questionnaire were...
To compare the corneal biomechanical changes after small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK) with same programmed optical zone (POZ) similar refractive correction patients high myopia.In this prospective comparative study of contralateral eye, 50 myopia POZ who underwent SMILE one eye FS-LASIK other eye. Corneal parameters central thickness (CCT) were measured using a Corvis ST II. All evaluated during follow-up visits beyond...
To investigate the ciliary body anatomy and position of implantable collamer lens (ICL) in low-vault eyes analyze factors related to insufficient vault.Zhongshan Ophthalmic Center, Guangzhou, China.Retrospective case-control observational study.In this study, 73 patients with an vault (<250 μm) were matched ideal (250 750 μm). Ultrasound biomicroscopy was used determine morphology ICL position. The biometric parameters acquired by Scheimpflug tomography compared. correlation between these...
Purpose: To assess and compare the dry-eye-associated parameters corneal biomechanical status after small-incision lenticule extraction (SMILE) femtosecond laser-assisted in situ keratomileusis (FS-LASIK).Methods: Sixty-five patients' (128 eyes) were collected between November 2012 April 2013. Thirty-five (69 underwent SMILE thirty (59 FS-LASIK. Visual acuity, manifest refraction, tear break-up time (TBUT), Schirmer's test (ST), sensitivity, Ocular Surface Disease Index (OSDI), hysteresis...
Ocular inflammation is a common pathological condition of series retinal degenerative diseases. Tetramethylpyrazine (TMP), Chinese herbal extraction, widely used in the treatment several ocular diseases Eastern countries. However, exact mechanisms correlating vision protective effects TMP have not been elucidated. Thus, this study aimed to investigate TMP's molecular targets anti-inflammatory activity endotoxin lipopolysaccharide (LPS)-induced both vitro and vivo. The primary cultured...
Purpose To examine lenticule decentration and visual quality following small incision extraction (SMILE) using either the coaxially sighted corneal light reflex (CSCLR) or tear film mark (TFM) centration method. Methods A total of 186 eyes from 93 patients were enrolled in this prospective, randomized, contralateral eye comparison study. Each patient had one randomly assigned to CSCLR group (n = 93) TFM 93). Visual outcomes, optical zone decentration, contrast sensitivity, higher order...
The aim of this study was to evaluate the difference between Caucasian and Chinese healthy subjects with regards Corvis ST dynamic corneal response parameters (DCRs). Two thousand eight hundred eighty-nine were included in multicenter retrospective study. Subsequently, eyes matched Caucasians by age, intraocular pressure (IOP), Corneal Thickness (CCT) using a case-control matching algorithm. DCRs assessed Deformation Amplitude (DA) Applanation 1 velocity (A1v), integrated radius (1/R),...
The Square Kilometre Array Observatory (SKAO) will explore the radio sky to new depths in order conduct transformational science. SKAO data products made available astronomers be correspondingly large and complex, requiring application of advanced analysis techniques extract key science findings. To this end, is conducting a series Science Data Challenges, each designed familiarise scientific community with drive development techniques. We present results from Challenge 2 (SDC2), which...
Abstract Background Implantable Collamer Lens (ICL) surgery has been proven to be a safe, effective, and predictable method for correcting myopia myopic astigmatism. However, predicting the vault ideal ICL size remains technically challenging. Despite growing use of artificial intelligence (AI) in ophthalmology, no AI studies have provided available choices different instruments combinations further predictions. This study aimed fill this gap predict post-operative appropriate utilizing...
BackgroundBone marrow stromal cells (BMSCs) are pluripotent and thereby a potential candidate for cell replacement therapy central nervous system degenerative disorders traumatic injury. However, the mechanism of their differentiation effect on neural tissues has not been fully elucidated. This study evaluates BMSCs growth survival in retinal ganglion (RGCs) model by assessing changes expression BMSC-secreted protein, thrombospondin-1 (TSP-1), as putative mechanistic agent acting...
Blue light is a major component of visible and digital displays. Over-exposure to blue could cause retinal damage. However, the mechanism its damage not well defined. Here, we demonstrate that (900 lux) impairs cell viability induces apoptosis in neurocytes vitro. A DNA electrophoresis assay shows severe at 2 h after treatment. γ-H2AX foci, specific marker double-strand breaks (DSBs), mainly located Map2-posotive neuron other than glia cell. After assaying expression level proteins related...
To compare small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK) terms of the predictability central stromal thickness reduction eyes with high myopia.In this prospective, randomized contralateral eye trial, 42 patients received SMILE one FS-LASIK (using Amaris 750S excimer laser [SCHWIND eye-tech-solutions]) fellow for correction myopia (manifest refraction spherical equivalent: < -6.00 diopters). Spectral-domain optical coherence...
To investigate the behaviors of smartphone usage and parental knowledge vision health among primary students in rural areas China.In this school-based, cross-sectional study, a total 52 606 parents from 30 schools Xingguo County were investigated through an online questionnaire July 2020 to August 2020. The self-designed contained three parts: demographic factors both children parents, attitude toward myopia, preventive treatment myopia.A 485 appropriately answered questionnaires received,...
Rationale: Microglia with a repertoire of functions are critical in pathological regulation angiogenesis the retina.However, retinal microglia beneficial contributions and corresponding mechanisms during neovascularization poorly understood.Methods: We conducted bioinformatic comparison public single-cell RNA transcriptome data between from mice oxygen-induced retinopathy (OIR) an antiangiogenic microglial population named MG3 spine.The essential factor thrombospondin-1 (Tsp-1) was...
Purpose: To evaluate the add-on effect of manual cyclotorsion error correction by cornea-marking method over standard small incision lenticule extraction (SMILE) surgery in astigmatic eyes. Methods: Consecutive patients (84) who had preoperative myopic astigmatism −0.75 diopters (D) or more and were seeking surgical refractive SMILE during July 2017 to August included this study randomized treatment with (S group: 30 eyes) compensated (CC 54 eyes). The visual acuity outcomes analyzed...
PURPOSE: To evaluate postoperative clinical outcomes in myopic eyes with astigmatism that underwent femtosecond laser small incision lenticule extraction (SMILE) surgery axis alignment. METHODS: Overall, 622 from 353 patients myopia and greater than −0.75 diopters (D) who had SMILE were included this prospective study. Standard examinations performed visual acuity vector values analyzed preoperatively postoperatively. RESULTS: Preoperative manifest spherical equivalent (SE) was −6.11 ± 1.68...
PURPOSE: To evaluate the corneal epithelial thickness (CET) profile changes after small incision lenticule extraction (SMILE) surgery for myopic astigmatism correction of greater than 2.00 diopters (D). METHODS: This prospective observational study included 40 eyes (23 patients) treated with SMILE myopia cylinders −2.25 to −4.50 D. Along standard ophthalmic examinations, CET maps a diameter 9 mm were measured by high-resolution spectral-domain optical coherence tomography preoperatively and...