A5100362390- Advanced biosensing and bioanalysis techniques
- Retinal Development and Disorders
- CRISPR and Genetic Engineering
- Biosensors and Analytical Detection
- RNA regulation and disease
- Antibiotic Resistance in Bacteria
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Photosynthetic Processes and Mechanisms
- Plant biochemistry and biosynthesis
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Algal biology and biofuel production
- Inflammasome and immune disorders
- Cancer-related gene regulation
- Ocular Disorders and Treatments
- Spectroscopy and Quantum Chemical Studies
- Orthoptera Research and Taxonomy
- Animal Behavior and Reproduction
- Cancer, Stress, Anesthesia, and Immune Response
- Trace Elements in Health
- Heme Oxygenase-1 and Carbon Monoxide
- Acute Kidney Injury Research
- MicroRNA in disease regulation
Agricultural Genomics Institute at Shenzhen
2025
Chinese Academy of Agricultural Sciences
2025
Ministry of Agriculture and Rural Affairs
2025
Zhengzhou University
2025
Yantai Academy of Agricultural Sciences
2024
Hainan Medical University
2024
Capital Medical University
2008-2024
Nankai University
2023-2024
Shenyang Pharmaceutical University
2023
Cancer Hospital of Huanxing Chaoyang District Beijing
2023
This work used sulfite as a coreactant to enhance the anodic electrochemiluminescence (ECL) of mercaptopropionic acid modified CdTe quantum dots (QDs). strategy proposed first ECL QDs and led sensitive emission in aqueous solution at relatively low potential. In presence dissolved oxygen, stable resulted from excited QDs. Thus, an detection method was +0.90 V (vs Ag/AgCl) based on quenching by analyte. Using tyrosine model compound, whose electrooxidized product could quench thus emission,...
A highly sensitive competitive immunosensor based on the electrochemiluminescence (ECL) of quantum dots (QDs) was proposed by coupling with an enzymatic amplification. The fabrication process traced atomic force microscopic images and electrochemical impedance spectra. strong cathodic ECL emission immobilized QDs could be detected at a relatively low potential. reduction dissolved oxygen during provided self-produced coreactant, H2O2, for emission. Using human IgG (HIgG) as model protein,...
Abstract Exosomes derived from tumor cells play a key role in development. In the present study, we identified bioactivity of exosomes released WERI-Rb1 retinoblastoma angiogenesis, as well underlying mechanism, through biochemical methods and animal experiments. Our vitro data showed that could be engulfed by human vesicle endothelial (HUVECs), significantly promote cell viability induce an inflammatory response HUVECs increasing expression series related genes, such IL-1, IL-6, IL-8,...
The high mutation rate of SARS-CoV-2 largely complicates our control the pandemic. In particular, it is currently unclear why spike ( S ) gene has an extraordinarily among all genes. By analyzing occurrence fixed synonymous mutations between and RaTG13, profiling DAF (derived allele frequency) polymorphic sites millions worldwide strains, we found that both show higher rates in than other majority are C-to-T, representing APOBEC-mediated C-to-U deamination instead previously proposed A-to-I...
Abstract Evolutionary adaptation is generally thought to occur through incremental mutational steps, but large leaps can during its early stages. These are challenging study in nature due the difficulty of observing new genetic variants as they arise and spread, characterizing their genomic dynamics important for understanding factors favoring rapid adaptation. Here, we report consequences recent, adaptive song loss a Hawaiian population field crickets (Teleogryllus oceanicus). A discrete...
Abstract Antibiotic resistance is an emerging public health issue. Plasmids are one of the popular carriers to disseminate genes among pathogens. However, response plasmid-carrying bacteria antibiotic treatment and how these evolve increase their remain elusive. In this study, we conjugated plasmid pNDM-HK E. coli J53 recipient cells selected survivors using different concentrations broad spectrum meropenem. After selection, transconjugants conferred varying minimum inhibitory with respect...
Esophageal cancer is the sixth leading causes of cancer-related death in world. It suggested that beta-adrenoceptor involved control cell proliferation, but its role pathogenesis esophageal remains unknown. We therefore studied beta-adrenergic signaling regulation growth an squamous-cell carcinoma line HKESC-1. Results showed both beta(1)- and beta(2)-adrenoceptors were expressed HKESC-1 cells. Stimulation beta-adrenoceptors with epinephrine significantly increased proliferation accompanied...
Abstract Hepatic ischemia-reperfusion (I/R) injury is a common complication in liver transplantation. The connection between I/R-induced response and heterogeneity has yet to be fully understood. In this study, we converge histopathological examination with spatial transcriptomics dissect I/R patterns their associated molecular changes, which reveal that the pericentral zones are most sensitive terms of histology, transcriptomic cell type dynamics. Bioinformatic analysis injury-related...
Autosomal recessive retinitis pigmentosa (RP), a heterogeneous group of degenerations the retina, can be due to mutations in MFRP (membrane-type frizzled-related protein) gene. A patient with RP mutations, one which is novel and first splice site mutation reported, was characterized by noninvasive retinal visual studies. The phenotype, albeit complex, suggested that this degeneration may candidate for gene-based therapy. Proof-of-concept studies were performed rd6 Mfrp mutant mouse model....
All mitochondrial tRNAs in kinetoplastid protozoa are encoded the nucleus and imported from cytosol. Incubation of two vitro-transcribed tRNAs, tRNAIle(UAU) tRNAGln(CUG), with isolated mitochondria Leishmania tarentolae, absence any added cytosolic fraction, resulted a protease-sensitive, ATP-dependent importation, as measured by nuclease protection. Evidence that protection represents importation was obtained finding Bacillus subtilis pre-tRNAAsp protected digestion also cleaved an...
Unchecked mitogenic signals due to the overexpression of epidermal growth factor (EGF) and its receptor (EGFR) is implicated in promotion progression cancer. In addition, β-adrenoceptor involved control cancer cell proliferation. This study sought elucidate whether a functional connection exists between these two disparate systems. EGF was used stimulate HKESC-1 cells, an esophageal squamous line, which activity monitored by measuring intracellular cAMP levels absence or presence...
Wear particle-induced aseptic loosening is the most common complication of total joint arthroplasty (TJA). Excessive osteoclast formation and bone resorptive activation have been considered to be responsible for extensive destruction prosthesis failure. Therefore, identification anti-osteoclastogenesis agents a potential therapy strategy treatment other osteoclast-related osteolysis diseases. In present study, we reported, first time, that piperlongumine (PL), key alkaloid compound from...
The dissemination of extended-spectrum β-lactamases (ESBLs) genes among bacteria is commonly achieved by plasmid conjugation. In the last decade, CTX-M type enzyme was most widespread and prevalent ESBLs in world. Hong Kong mainland China, found CTX-M-carrying plasmids were pHK01 pHK01-like plasmids, which belong to incompatibility group FII (IncFII). this work, we studied physiological effect caused bacterial host Escherichia coli J53. did not affect cell growth but reduced their motility....