A5083095046- Effects of Radiation Exposure
- Listeria monocytogenes in Food Safety
- Microplastics and Plastic Pollution
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Microbial Inactivation Methods
- Phytochemicals and Antioxidant Activities
- Cancer, Hypoxia, and Metabolism
- Recycling and Waste Management Techniques
- Nanoparticles: synthesis and applications
- Phytoestrogen effects and research
- Food Safety and Hygiene
- Postharvest Quality and Shelf Life Management
- Circular RNAs in diseases
- Morinda citrifolia extract uses
- Essential Oils and Antimicrobial Activity
- Acupuncture Treatment Research Studies
- Radiation Therapy and Dosimetry
- Histone Deacetylase Inhibitors Research
- Radiation Effects and Dosimetry
- Biochemical effects in animals
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Plant chemical constituents analysis
- Healthcare and Venom Research
Shanghai University of Traditional Chinese Medicine
2024-2025
Shandong Normal University
2025
Nanchang University
2022-2024
First People's Hospital of Kunshan
2024
Jiangsu University
2024
Capital Medical University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2023
Tumor Hospital of Guangxi Medical University
2019
Louisiana State University
2016-2018
University of Delaware
2012-2016
Nanoplastics (NPs) have recently emerged in the context of global plastic pollution. They may be more toxic than macroplastics litter and microplastic fragments due to its abundances, tiny sizes, cellular accessibility. The female reproductive toxicity NPs has been widely documented for aquatic animals, but their effects underlying mechanisms remain poorly understood mammals. This study aimed explore on reproduction using human ovarian granulosa cells (GCs) mice. accumulation polystyrene...
Purpose: Caffeic acid phenethyl ester (CAPE) is the main polyphenol extracted from honeybee propolis, which inhibits growth of several kinds tumor. This study aimed to assess inhibitory effect CAPE in nasopharyngeal carcinoma (NPC), evaluate synergistic action radiotherapy sensitivity NPC cell lines and further elucidate possible molecular mechanism involved. Materials methods: CCK-8 assay was used analyze proliferation ability. Colony formation clonogenic ability radio-sensitiveness cells...
Abstract Ozonated water washing is one of the emerging techniques to inactivate foodborne pathogens on produce, and limited information available optimize processing parameters (treatment time, temperature, pH) improve ozone efficacy Salmonella inactivation for different produce. The ozonated enterica Typhimurium green onions, grape tomatoes leaf lettuces were studied in our research. Surface inoculated fresh produce washed by 1, 5, or 10 min at room temperature pH 5.60 ± 0.03. Then mild...
Abstract In semiconductor technology, bandgap engineering is a cornerstone challenge that continues to evolve. By employing the full and low-energy tight-binding model, we focused on effects of twist-angle bandgaps twisted bilayer γ -graphyne graphdiyne. Our results indicated reducing from 21.79 ∘ 0.67 can significantly narrow by as much 0.5 eV. Drawing concept hybridization, this reduction in elucidated average interlayer coupling valence band maximum state conduction minimum state....
Inflammation is a crucial element of immune responses, with pivotal roles in host defenses against pathogens. Comprehensive understanding the molecular mechanisms underlying inflammation imperative for developing effective strategies to combat infectious diseases. Here, we conducted screening analysis and identified enkurin domain-containing protein 1 (ENKD1) as promising regulator inflammation. We observed that ENKD1 expression was significantly reduced on activation multiple Toll-like...
WTF-B, a type of water-soluble homogeneous polysaccharide, was isolated and purified from Tremella Fuciformis. To investigate the radioprotective effect we employed 30-day survival assay. Mice were treated with WTF-B once per day for three consecutive days before 8-Gy gamma irradiation. The treatment groups receiving 54 72 mg/kg body weight (b.w.) showed 50% post-irradiation. hematological parameters peripheral blood indicated that when administered at doses b.w., significantly restored...
Abstract The Hippo signalling pathway has been considered as potential therapeutic target in self‐renewal and differentiation of stem progenitor cells. Thus, mammalian Ste20‐like kinase 1/2 (MST1/2) the core serine‐threonine kinases investigated for its role immunological disease. However, little information MST1/2 function bone marrow suppression induced by ionizing radiation was fully investigated. Here, we reported that inhibitor XMU‐MP‐1 could rescue impaired haematopoietic cells (HSCs)...
Rosmarinic acid (RA) is an ester of caffeic and 3, 4-dihydroxyphenyl lactic acid. It a potent antioxidant that functions by scavenging free radicals. Here, we used 30-day survival assay to investigate the radioprotective effects RA. Mice were treated with RA once per day for 10 consecutive days starting at 3 before gamma irradiation 7.5 Gy until 7 post irradiation. 100 200 mg/kg body weight (bw) had rates 89% 72%, respectively, compared 32% in control group, differences statistically...
Mutation of the proto-oncogene K-Ras is one most common molecular mechanisms in non-small cell lung cancer. Many drugs for treating cancer have been developed, however, due to clinical observed mutations, corresponding chemotherapy and targeted therapy such mutation are not efficient enough. In this study, on basis crystal structure K-Ras, 21 analogues (TKR01-TKR21) containing urea or thiourea were rationally designed, which can effectively inhibit A549 growth. The designing these compounds...
Risk stratification for patients with acute pulmonary embolism (APE) is significantly important treatment and prognosis evaluation. We aimed to develop a novel clot burden score on computed tomography angiography (CTPA) based deep learning (DL) algorithm risk of APE.
We previously reported methylstat as a selective inhibitor of jumonji C domain-containing histone demethylases (JHDMs). Herein, we describe the synthesis fluorescent analogue and its application tracer in fluorescence polarization assays. Using this format, have evaluated binding affinities several known JHDM probes, well native cofactor substrate JHDM1A. This fluorophore allowed highly robust miniaturized competition assay sufficient for high-throughput screening.
Abstract Background As we know, radiotherapy plays an irreplaceable role in the clinical management on solid tumors. However, due to non-specific killing effects of ionizing radiation, normal tissues damages would be almost simultaneous inevitably. Therefore, ideal radioprotective agents with high efficiency and low toxicity are always desirable. In this work, atomically precise Ag 14 clusterzymes were developed, their applications radioprotection studied vitro vivo for first time. Methods...