A5067518465- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- Diet and metabolism studies
- Chemokine receptors and signaling
- Healthcare and Venom Research
- Hedgehog Signaling Pathway Studies
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Cellular transport and secretion
- interferon and immune responses
- Viral-associated cancers and disorders
- Renal and related cancers
- Nuts composition and effects
- Wnt/β-catenin signaling in development and cancer
- Bee Products Chemical Analysis
First Affiliated Hospital of GuangXi Medical University
2019-2020
Guangxi Medical University
2019-2020
Tumor Hospital of Guangxi Medical University
2019
Purpose: Caffeic acid phenethyl ester (CAPE) is the main polyphenol extracted from honeybee propolis, which inhibits growth of several kinds tumor. This study aimed to assess inhibitory effect CAPE in nasopharyngeal carcinoma (NPC), evaluate synergistic action radiotherapy sensitivity NPC cell lines and further elucidate possible molecular mechanism involved. Materials methods: CCK-8 assay was used analyze proliferation ability. Colony formation clonogenic ability radio-sensitiveness cells...
Kidney is an important organ for ketone body metabolism. However, the role of abnormal metabolism and its possible function in tumorigenesis clear cell renal carcinoma (ccRCC) have not yet been elucidated. Three differentially expressed key enzymes involved metabolism, ACAT1, BDH2, HMGCL, were screened out between ccRCC normal kidney tissues using GEO TCGA databases.We confirmed that transcription protein expression HMGCL significantly lower by real-time RT-PCR IHC assays. Those patients...
3-Hydroxybutyrate dehydrogenase type 2 (BDH2) is known to catalyse a rate-limiting step in the biogenesis of mammalian siderophore and regulate intracellular iron metabolism. Here we aim explore expression possible function BDH2 nasopharyngeal carcinoma (NPC).The transcription protein NPC were determined by both real-time RT-PCR immunohistochemistry staining assays. Cell proliferation, migration invasion evaluated MTT assay, wound-healing assay Transwell respectively. The profile genes...
BACKGROUND:Aberrant expression of cadherin family members and their possible biological function have been widely studied in renal cell carcinoma (RCC). However, the 4 (CDH4) its value RCC diagnosis prognosis remains elusive. MATERIAL AND METHODS:The TCGA database was used to analyze CDH4 clinical parameters 891 patients. In addition, real-time PCR verify transcription clear tissue, distribution protein observed by immunohistochemical staining. RESULTS:We found that mRNA level elevated...
BACKGROUND Chemokines are important in inflammation, immunity, tumor progression, and metastasis. The purpose of this research was to find an integrated-RNA signature chemokine family genes predict the survival prognosis head neck squamous carcinoma (HNSC) patients. MATERIAL AND METHODS Relevant data 504 HNSC patients were extracted from Cancer Genome Atlas (TCGA) database. Through analyzing RNA sequencing data, univariate Cox model used identify associated with then develop a multiple-RNA...
Abstract Rab11 family interacting protein 2 (Rab11‐FIP2) is a conserved and effector molecule for the small GTPase Rab11. By with MYO5B, Rab11‐FIP2 regulates endosome trafficking of plasma membrane proteins, promoting cellular motility. The endosomal system in nasopharyngeal carcinoma (NPC) remains unclear. Here, an outlier analysis using Oncomine database suggested that but not MYO5B was overexpressed NPC. We confirmed transcription upregulated NPC cell lines primary tumor tissues as...