A5005172664- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Ophthalmology and Eye Disorders
- Ocular Surface and Contact Lens
- Retinal Imaging and Analysis
- Optical Coherence Tomography Applications
- Proteoglycans and glycosaminoglycans research
- Retinal and Macular Surgery
- Ocular Infections and Treatments
- Ocular Oncology and Treatments
- Cerebral Venous Sinus Thrombosis
- Facial Rejuvenation and Surgery Techniques
- Peripheral Artery Disease Management
- Retinal Development and Disorders
- Retinopathy of Prematurity Studies
- Dermatologic Treatments and Research
- Facial Trauma and Fracture Management
- Cancer Treatment and Pharmacology
- Phytochemistry and Biological Activities
- Coronary Interventions and Diagnostics
- Retinal and Optic Conditions
- Ocular Disorders and Treatments
- Advanced MRI Techniques and Applications
National University Hospital
2014-2023
National University Health System
2011-2022
National University of Singapore
2011-2022
Ophthalmology Associates (United States)
2018
Sheffield Teaching Hospitals NHS Foundation Trust
2017
Singapore National Eye Center
2000-2015
Singapore Eye Research Institute
2003-2015
University Health System
2012-2013
Sydney Hospital
2012
University of Aberdeen
2011
The aim of this study was to compare the efficacy and safety micropulse continuous wave diode transscleral cyclophotocoagulation in refractory glaucoma.Randomized, comparative, exploratory a tertiary hospital setting.Patients with refractory, end-stage glaucoma.Forty-eight patients were randomized either treatment. intraocular pressure, visual acuity, number medicines repeat treatment monitored for 18 months. Complications that include acuity decline, prolonged anterior chamber inflammation,...
Transscleral diode laser cyclophotocoagulation (TSCPC) is an established method of treatment for refractory glaucoma, but associated with significant complications. This study evaluates the efficacy and safety a new form TSCPC using micropulse trans-pars plana novel contact probe.Prospective interventional case series 40 eyes 38 consecutive patients glaucoma treated probe. Outcomes measured were success, hypotony response rates.The mean age was 63.2 +/- 16.0 years. The follow-up period 16.3...
To evaluate different mechanisms of primary angle closure and to quantify anterior chamber parameters in these using segment optical coherence tomography an Asian population.Hospital-based cross-sectional observational study.Forty-eight consecutive patients with glaucoma.Patients underwent complete ophthalmic examination imaging nasal-temporal angles tomography. Images were categorized into four mechanisms: pupil block, plateau iris configuration, Thick peripheral roll exaggerated lens...
To evaluate the reproducibility of anterior chamber (AC) angle measurements obtained using segment optical coherence tomography (AS-OCT).Patients with suspected glaucoma and those glaucoma, ocular hypertension, or anatomically narrow angles were recruited from service at National University Hospital, Singapore. All subjects underwent imaging nasal, temporal, inferior AC an AS-OCT prototype under standardized dark light conditions. For short-term analysis, a single observer acquired two sets...
<h3>Objective</h3>To determine whether the timing of cataract surgery after trabeculectomy has an effect on function in terms intraocular pressure control.<h3>Methods</h3>This was a cohort study nested within randomized clinical trial. There were 235 participants with glaucoma who had single previous augmented either intraoperative 5-fluorouracil or placebo. Cataract lens implantation performed judged to have significant opacity. Cox regression evaluate time between and failure, adjusting...
Anterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted genome-wide association study (GWAS) on ACD to discover novel genes PACG total of 5,308 population-based individuals Asian descent. Genome-wide significant was observed at sequence variant within ABCC5 (rs1401999; per-allele effect size = −0.045 mm, P 8.17×10−9). This locus associated with an increase in separate case-control 4,276 cases and 18,801 controls (per-allele OR 1.13...
Glaucoma is the leading cause of irreversible blindness. Although primary open-angle glaucoma more common, angle-closure (PACG) likely to result in By 2020, 5·3 million people worldwide will be blind because PACG. The current standard care for PACG a stepped approach combination laser iridotomy surgery (to open drainage angle) and medical treatment reduce intraocular pressure). If these treatments fail, (eg, trabeculectomy) indicated. It has been proposed that, lens eye plays major role...
Purpose This study compared the intraocular pressure (IOP)-lowering efficacy of 2 fixed combination products, brinzolamide 1%/timolol 0.5% suspension (Azarga, Brinz/Tim) and dorzolamide 2%/timolol solution (Dorz/Tim), in patients with open-angle glaucoma or ocular hypertension who required a change therapy due to elevated IOP while receiving IOP-lowering medication. Methods was one-year, multicenter, randomized, double-masked, active-controlled, parallel-group trial Brinz/Tim Dorz/Tim....
Effective feature selection plays a vital role in anterior segment imaging for determining the mechanism involved angle-closure glaucoma (ACG) diagnosis. This research focuses on use of redundant features complex disease diagnosis such as ACG using optical coherence tomography images. Both supervised [minimum redundancy maximum relevance (MRMR)] and unsupervised [Laplacian score (L-score)] algorithms have been cross-examined with different mechanisms. An AdaBoost machine learning classifier...
Purpose To identify the factors which significantly contribute to thickness variabilities in macular retinal layers measured by optical coherence tomography with or without magnification correction of analytical areas normal subjects. Methods The {retinal nerve fiber layer (RNFL), ganglion cell plus inner plexiform (GCLIPL), RNFL GCLIPL (ganglion complex, GCC), total retina, retina minus GCC (outer retina)} were scans (RS-3000, NIDEK) 202 eyes Asian subjects aged 20 60 years. defined three...
Purpose To measure changes in angle width after phacoemulsification and intraocular lens (IOL) implantation using anterior segment optical coherence tomography (AS-OCT). Materials Methods Twenty-one patients undergoing cataract surgery were recruited from the National University Hospital, Singapore. AS-OCT images obtained of nasal temporal quadrants before at 1-month surgery. Optical measurements central chamber depth obtained, gonioscopic measurement was recorded. parameters measured...