A5056412026- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Ophthalmology and Visual Impairment Studies
- Intraocular Surgery and Lenses
- Ophthalmology and Eye Disorders
- Ocular Surface and Contact Lens
- Retinal and Optic Conditions
- Cerebral Venous Sinus Thrombosis
- Corneal Surgery and Treatments
- Ophthalmology and Visual Health Research
- Retinal and Macular Surgery
- Neurological Disorders and Treatments
- Visual perception and processing mechanisms
- Retinal Development and Disorders
- Ocular Infections and Treatments
- Pharmaceutical industry and healthcare
- Obstructive Sleep Apnea Research
- Proteoglycans and glycosaminoglycans research
- Traumatic Ocular and Foreign Body Injuries
- Dental Education, Practice, Research
- Clinical practice guidelines implementation
- Global Health Workforce Issues
- Retinopathy of Prematurity Studies
University of Toronto
2015-2025
University Health Network
2005-2025
Western University
2008-2023
Kensington Health
2021-2023
3M (United States)
2023
Krembil Research Institute
2018-2022
Toronto Western Hospital
2013-2022
St. Michael's Hospital
1987-2020
Krembil Foundation
2019
Western Research Institute
2018
A glaucoma locus, GLC1A, was identified previously on chromosome 1q. gene within this locus (encoding the protein myocilin) subsequently shown to harbor mutations in 2–4% of primary open angle patients. total 1703 patients screened from five different populations representing three racial groups. There were 1284 primarily Caucasian Iowa (727), Australia (390) and Canada (167). group 312 African American New York City 107 Asian Japan. Overall, 61 myocilin sequence variations identified. Of...
The purpose of this study was to determine the mechanical response lamina cribrosa (LC) elevated intraocular pressure (IOP) so as identify possible mechanisms optic nerve damage in early glaucoma. Ten pairs normal human eyes were fixed after 24 hours' exposure 50 mm Hg (experimental eyes) or 5 (contralateral control eyes). Photomicrographs central region head (ONH) taken examine LC morphologically and measure dimensions LC. It found that IOP caused deflect posteriorly without affecting its...
To determine rates of visual field change associated with risk factors for progression in the Canadian Glaucoma Study (abnormal anticardiolipin antibody level, age, female sex, and mean follow-up intraocular pressure [IOP]), to evaluate effect IOP reduction on subsequent progressing patients.Two hundred sixteen patients (median 65.2 years) were followed up at 4-month intervals perimetry monitored progression. Patients reaching an end point based total deviation analysis underwent 20% or...
Blood viscosity and several haemostatic factors were measured in 42 patients with long-standing retinal vein occlusion 33 control subjects. viscosity, haematocrit, plasma fibrinogen, fibrinopeptide A, beta-thromboglobulin increased the 20 subjects capillary nonperfusion or new vessels, but not 22 without these complications. Patients vessels also had a lower platelet count than Increased levels of factor VIII antigen decreased antithrombin III found group as whole. These findings suggest...
To investigate diurnal change and pattern of variation in intraocular pressure (IOP) systolic (SBP) diastolic (DSP) blood pressures a group with untreated primary open-angle glaucoma (uPOAG) compare it an age-matched, normal group.IOP, SBP, DBP were measured 14 patients uPOAG subjects, every hour between 7 AM 10 PM the mean ocular perfusion (MOPP) was calculated. Mixed-effect linear models used to analyze repeated-measures data which both fixed random effects included. The relative...
Background: In a collaborative study, patients with untreated normal-tension glaucoma were randomly assigned to marked intraocular pressure reduction group or no therapy group. It was anticipated that medical and laser trabeculoplasty would generally not achieve adequate lowering fistulizing surgery be required. This hypothesis examined using current observations in the study. Methods: Patients randomized had of at least 30% from their last prerandomization level. achieved within 6 months by...
To compare the efficacy and safety of Ex-PRESS glaucoma shunt with standard trabeculectomy.Consenting patients medically uncontrolled open-angle were prospectively randomized to trabeculectomy or both mitomycin-C. Exclusion criteria included previous ocular surgery exception clear cornea phaco 1 trabeculectomy, uveitis, vitreous in anterior chamber. Standardized data collection sheets completed at baseline postoperative day 1, weeks 2, months 3, 6, 12. Primary outcome was intraocular...
<h3>Aims</h3> To compare the outcomes of Ex-PRESS versus trabeculectomy at 3 years. <h3>Methods</h3> Consenting patients aged 18–85 years with medically uncontrolled open-angle glaucoma scheduled for were included in this study. 63 subjects randomised to undergo (32) or (31). Follow-up data intraocular pressure (IOP), medications, visual acuity (VA), complications and additional interventions. Complete success was defined as IOP between 5 18 mm Hg 20% reduction from baseline without while...
Synthetic prostaglandin analogues, such as latanoprost, are first-line treatments to reduce intraocular pressure (IOP) in the management of glaucoma, treating millions patients daily. Glaucoma is a leading cause blindness, characterized by progressive optic neuropathy, with elevated IOP being sole modifiable risk factor. Despite this importance, underlying latanoprost mechanism still not well defined, associated both acute and long term activities, ocular side effects. Prostaglandins...
Purpose: Conjunctival complications may occur after glaucoma drainage device surgery. We analyzed the frequency, risk factors, management and outcomes of Ahmed valve (AGV)-related conjunctival complications. Methods: Retrospective review postoperative in patients undergoing AGV insertion. Only subjects with ≥1-year follow-up were included. Results: The charts 158 a median age 64±16.2 years reviewed. Median was 43.5 months (range, 12 to 103 mo). Fifty-three (33.5%) wound dehiscences 14 (8.9%)...
To compare the rate of visual recovery after Ex-PRESS implantation versus standard trabeculectomy.Subjects enrolled in a prospective randomized controlled trial comparing to trabeculectomy were analyzed for postoperative changes acuity (VA). Risk factors loss (split fixation, cup-disc ratio, intraocular pressure, field mean deviation, and hypotony) evaluated.Sixty-four subjects (33 Ex-PRESS, 31 trabeculectomy). There was no significant difference logMAR VA between groups at baseline or any...
Social participation benefits health. We assessed the relationship between self-reported visual impairment (VI) and glaucoma versus seniors' social participation.Data from individuals aged ≥65 years responding to Canadian Community Health Survey Healthy Aging 2008/2009 (n = 16,369) was analyzed. Participation in eight activities by seniors with without VI or compared.Seniors had significantly reduced (p<0.05) sports/physical (18.0% vs. 33.6%), family/friendship outside household (39.7%...
Retinal ganglion cells (RGCs) have been shown to die by apoptosis after damage their axons caused optic nerve crush and the death can be reduced some neurotrophic factors. Since (-)-deprenyl reduce apoptotic in neuronal systems, we determined whether it increase RGC survival crush. Fluoro-Gold (FG), a fluorescent retrograde tracer, was injected into both superior colliculi pre-label bodies retinal cell layers (RGCLs) of adult Sprague-Dawley rats. Fours days later, left crushed immediately...
This paper deals with our findings on the quantities of melanin in tissues from blue and brown eyes. The amount iris, ciliary body retinal pigment epithelium-choroid was separately determined. results are expressed as mg tissue well whole tissue. showed that there no statistically significant difference between content iris However eyes had more than corresponding Blue higher colour intensity lesser colour. It is suggested differences their may have relevance to pharmacokinetics drugs bind...
A longitudinal, retrospective study investigated the cost of primary open angle glaucoma (POAG).Patient files from two tertiary care practices were reviewed. Patients diagnosed with POAG and >/=2.5 years follow-up data included. Data collected included visual field mean deviation, physician's assessment, resource utilization (physician visits, procedures, medications). Costs, reported in 2001 Canadian dollars, compared between groups, based on initial including mild (<5 dB), moderate (5 to...