A5006579982- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Ophthalmology and Eye Disorders
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Corneal Surgery and Treatments
- Retinal and Macular Surgery
- Cerebral Venous Sinus Thrombosis
- Retinopathy of Prematurity Studies
- Ocular Surface and Contact Lens
- Connexins and lens biology
- Genomic variations and chromosomal abnormalities
- Proteoglycans and glycosaminoglycans research
- Neurological Disorders and Treatments
- Developmental Biology and Gene Regulation
- Connective tissue disorders research
- Ophthalmology and Visual Impairment Studies
- Retinal and Optic Conditions
- Genetic Neurodegenerative Diseases
- Ocular Oncology and Treatments
- melanin and skin pigmentation
- Hedgehog Signaling Pathway Studies
- Sympathectomy and Hyperhidrosis Treatments
University of Iowa
2015-2025
University of Iowa Hospitals and Clinics
1995-2021
Christie's
2015-2016
Prevent Blindness
2007-2015
Research to Prevent Blindness
2007-2015
University of Kansas Medical Center
2014
University Medical Center
2014
Iowa City Public Library
1989-2013
United States Department of Veterans Affairs
2007
Iowa City VA Medical Center
2007
Glaucoma is a major cause of blindness and characterized by progressive degeneration the optic nerve usually associated with elevated intraocular pressure. Analyses sequence tagged site (STS) content haplotype sharing between families affected chromosome 1q-linked open angle glaucoma ( GLC1A ) were used to prioritize candidate genes for mutation screening. A gene encoding trabecular meshwork protein TIGR mapped narrowest disease interval STS radiation hybrid mapping. Thirteen patients found...
Yupik Eskimos of southwestern Alaska have the highest known prevalence hepatitis B virus infection any general population in United States. Prospective serological surveys 1,280 seronegative Eskimos, performed between 1971 and 1976, identified 189 (14.8%) who developed evidence infection. Twenty-six (13.8%) clinical during interval when seroconversion occurred. The proportion patients with clinically apparent increased age (P less than .01), ranging from 9.5% infections were four years or to...
A glaucoma locus, GLC1A, was identified previously on chromosome 1q. gene within this locus (encoding the protein myocilin) subsequently shown to harbor mutations in 2–4% of primary open angle patients. total 1703 patients screened from five different populations representing three racial groups. There were 1284 primarily Caucasian Iowa (727), Australia (390) and Canada (167). group 312 African American New York City 107 Asian Japan. Overall, 61 myocilin sequence variations identified. Of...
A substantial proportion of cases glaucoma have a genetic basis. Mutations causing been identified in the chromosome 1 open-angle gene (GLC1A), which encodes 57-kd protein known as myocilin. The normal role this and mechanism by mutations cause are not known.
Anterior segment developmental disorders, including Axenfeld–Rieger anomaly (ARA), variably associate with harmfully elevated intraocular pressure (IOP), which causes glaucoma. Clinically observed dysgenesis does not correlate IOP, however, and the etiology of glaucoma development is understood. The forkhead transcription factor genes Foxc1 (formerly Mf1) Foxc2 Mfh1) are expressed in mesenchyme from ocular drainage structures derive. Mutations human homolog Foxc1, FKHL7, cause dominant...
purpose. To evaluate a novel automated segmentation algorithm for cup-to-disc from stereo color photographs of patients with glaucoma the measurement progression. methods. Stereo optic disc were obtained by using fixed stereo-base fundus camera in 58 eyes suspected or open-angle glaucoma. Manual planimetry was performed three faculty members to delineate reference standard rim and cup all pairs fellows as well. Pixel feature classification evaluated on corresponding standard, computation...
We report identification of a novel genetic locus ( GLC1P ) for normal tension glaucoma (NTG) on chromosome 12q14 using linkage studies an African-American pedigree (maximum non-parametric score = 19.7, max LOD 2.7). Subsequent comparative genomic hybridization and quantitative polymerase chain reaction (PCR) experiments identified 780 kbp duplication within the that is co-inherited with NTG in pedigree. Real-time PCR showed genes this [ TBK1 (TANK-binding kinase 1), XPOT , RASSF3 GNS ] are...
One hundred fifty asymptomatic patients who were carriers of hepatitis B surface antigen (HBsAg) studied serologically for up to 11.3 years (mean, 6.1 years). Only 9 (6.0%) lost HBsAg during the study period, a mean annual clearance rate 1.0%. We found no difference in by age, but higher percentage females than did males (P less .02). Hepatitis e (HBeAg) was 102 (68.5%) 149 tested. Carriers seropositive HBeAg younger those seronegative .01). The prevalence not affected patients' sex....