A5064862848- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- CAR-T cell therapy research
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Histone Deacetylase Inhibitors Research
- Circular RNAs in diseases
- Multiple Myeloma Research and Treatments
- Ubiquitin and proteasome pathways
- DNA and Nucleic Acid Chemistry
- Biosimilars and Bioanalytical Methods
- Cancer, Hypoxia, and Metabolism
- Calcium signaling and nucleotide metabolism
- NF-κB Signaling Pathways
- Cancer Treatment and Pharmacology
- Acute Lymphoblastic Leukemia research
- Ginseng Biological Effects and Applications
- Algal biology and biofuel production
- Glutathione Transferases and Polymorphisms
- Curcumin's Biomedical Applications
- Bioactive natural compounds
Second Affiliated Hospital of Xi'an Jiaotong University
2017-2025
First Affiliated Hospital of Henan University
2021-2024
Liaocheng University
2024
Xi'an Jiaotong University
2019-2024
Southwest University
2024
Henan University of Traditional Chinese Medicine
2015-2021
Shanghai Institute of Hematology
2010-2013
Shanghai Institutes for Biological Sciences
2013
Shanghai Jiao Tong University
2010-2013
Ruijin Hospital
2010
The autologous anti-B-cell maturation antigen (BCMA) chimeric receptor (CAR) T-cell therapy LCAR-B38M has been approved for the treatment of relapsed and refractory multiple myeloma in many countries across world under name ciltacabtagene autoleucel. LEGEND-2 was first-in-human trial yielded deep durable therapeutic responses. Here, we reported outcomes after a minimal 5-year follow-up.
Circular RNAs (circRNAs) are a family of novel non-coding associated with various diseases, especially cancer. Recent studies have demonstrated that circRNAs participate in pathogenesis mainly by acting as microRNA (miRNA) sponges. The expression profile acute myeloid leukemia (AML) has rarely been reported.Profiles were analyzed using an Arraystar human circRNA microarray 5 bone marrow samples from patients newly diagnosed AML and iron-deficiency anemia. Quantitative reverse transcription...
Eriocalyxin B (EriB), a diterpenoid isolated from Isodon eriocalyx , was previously reported to have antitumor effects via multiple pathways, and these pathways are related immune responses. In this study, we demonstrated that EriB efficacious in experimental autoimmune encephalomyelitis (EAE), an animal model for sclerosis. Treatment with led amelioration of EAE, which correlated reduced spinal cord inflammation demyelination. treatment abolished encephalitogenic T-cell responses myelin...
LBA3001 The full, final text of this abstract will be available at abstracts.asco.org 7:30 AM (EDT) on Monday, June 5, 2017, and in the Annual Meeting Proceedings online supplement to 20, issue Journal Clinical Oncology. Onsite Meeting, printed Monday edition ASCO Daily News.
Natural killer (NK) cells are innate immune effectors with potent antitumor activity. However, tumor can create an immunosuppressive microenvironment to escape surveillance. Although accumulating evidence indicates that microenvironmental hypoxia plays important role in favoring development and evasion, it remains unclear by what means directly impairs NK cell In this study, we confirmed hypoxic showed significantly lower cytotoxicity against cells. Consistent finding, found the reduction...
As a key reactive oxygen species (ROS), hypochlorous acid (HClO) plays an important role in many physiological and pathological processes. The mitochondria-targeting probes for the highly sensitive detection of HClO are desirable. In present work, we designed synthesized original mitochondria-localizing turn-on fluorescent probe detecting HClO. 4-Aminonaphthalimide was employed as section, (2-aminoethyl)-thiourea unit utilized typical sensing unit, quaternized pyridinium moiety used...
Abstract GC (Gastric cancer) is one of the most common malignant tumours, with over 95% gastric cancer patients being adenocarcinoma and having no apparent symptoms in early stages. Finding biomarkers for screening exploring new targets treatment are urgent problems to be solved cancer, significant clinical outcomes survival rate patients. The AAA+ family ATPase thyroid hormone receptor-interacting protein 13 (TRIP13) has been reported play an essential role developing various tumours....
To investigate the inhibition effect of oxymatrine induces human lung cancer A549 cells apoptosis. The were cultured for 24 h, than various concentration (2 mmol/L, 4 8 15 mmol/L) added into different experimental group cells, and 5-fluorouracil positive control 12 36 48 h respectively. rate, apoptosis, expression Bcl-2 Bax examined by MTT method, Annexin V/PI double staining real-time quantitative PCR western blot, At same time, morphological changes observed with an inverted microscope. In...
Mesenchymal stem cells (MSCs) are multipotent capable of differentiating into a variety cell types. Bortezomib, the first approved proteasome inhibitor used for treatment multiple myeloma (MM), has been shown to induce osteoblast differentiation, making it beneficial bone disease. In present study, we aimed investigate effects and underlying mechanisms bortezomib on cycle during osteogenic differentiation. We confirmed that low doses can MSCs towards but high toxic. course bortezomib-induced...
Context:Panax ginseng C. A. Meyer (Araliaceae) root and leaf have always been considered in the traditional theory as hot cold properties, respectively.Objective: To clarify properties of from a thermodynamic viewpoint.Materials methods: Thirty ICR male mice were randomly assigned to control (water), group (GRP) (GLP) with concentration 0.075 g/mL; volume was 0.1 mL/10 g (body mass) per day by intragastric administration for 20 days. Ultra-Performance Liquid Chromatography (UPLC) used...
The objective of this study was to investigate the effect human esophageal fibroblast-derived exosomal miR-21 on cisplatin sensitivity against squamous EC9706 cells. cells were co-cultured indirectly with fibroblasts (HEF) or mimics transfected-HEF in transwell system. exosomes HEF-culture conditioned medium extracted by differential ultracentrifugation. HEF-derived directly. revealed via half maximal inhibitory concentration (IC50) values using MTT assay. expressions miR-21, programmed cell...
<title>Abstract</title> GC (Gastric cancer) is one of the most common malignant tumors, with over 95% gastric cancer patients being adenocarcinoma and having no obvious symptoms in early stages. Therefore, finding biomarkers for screening exploring new targets treatment are urgent problems to be solved cancer, it has important clinical significance improving survival rate patients. The AAA + family ATPase thyroid hormone receptor interacting protein 13 (TRIP13) been reported play an role...
Abstract The emergence of abnormal protein bands (APBs), also known as oligoclonal bands, has been documented in patients with multiple myeloma (MM) post hematopoietic stem cell transplantation. However, the incidence rate and clinical significance APBs remain contentious. Few studies have explored occurrence prognostic implications MM treated B‐cell maturation antigen (BCMA)–specific chimeric receptor (CAR)‐T therapy. In this retrospective study, we examined frequency, isotypes, duration...
The effects of the tested factors including pH value, NaCl concentration, ODN concentration and charge ratio on size zeta potentials nanoparticles (ODN-PLL, PLL: poly(l-lysine)s) were investigated by use uniform design NGR peptides used to modify nanoparticles, indicating that none was correlated with size, however, a linear correlation (r = 0.8505) found between potential. A nanosize delivery system (ODN-PLL-NGR) function targeting tumor cells developed PLL condense oligonucleotide into...