A5100667815- RNA modifications and cancer
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Chemokine receptors and signaling
- PI3K/AKT/mTOR signaling in cancer
- Immune cells in cancer
- DNA Repair Mechanisms
- interferon and immune responses
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Inflammatory mediators and NSAID effects
- Selenium in Biological Systems
- Cancer, Hypoxia, and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Circular RNAs in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Natural product bioactivities and synthesis
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
University of Hawaiʻi at Mānoa
2017-2025
Hainan University
2024-2025
Hua Medicine (China)
2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2025
Shanghai University of Traditional Chinese Medicine
2023-2025
Union Hospital
2024
Huazhong University of Science and Technology
2024
Harbin Medical University
2023-2024
Fourth Affiliated Hospital of Harbin Medical University
2023-2024
Dali University
2023-2024
Systemic treatment options for NSCLC with brain metastases (BMs) are scarce. We evaluated the activity and safety of camrelizumab plus chemotherapy as first-line therapy in patients advanced nonsquamous BMs. This was a multicenter, single-arm, phase 2 trial (NCT04211090) conducted at seven hospitals China. Eligible had treatment-naive metastatic BMs that were asymptomatic or symptoms controlled dehydration no previous systemic local target lesion. Patients received (200 mg) pemetrexed (500...
Idiopathic pulmonary fibrosis (IPF) is a progressive fatal interstitial lung disease without an effective cure. Herein, we explore the role of 3,5,3′-triiodothyronine (T3) administration on alveolar regeneration and at single-cell level. T3 supplementation significantly altered gene expression in fibrotic tissues. Immune cells were rapidly recruited into after injury; there much more M2 macrophages than M1 lungs bleomycin-treated mice; increased slightly, whereas reduced treatment. enhanced...
Abstract It has been confirmed that BTB domain and CNC homologue 1 (BACH1) are involved in ferroptosis‐related diseases. However, the function of BACH1 cerebral ischemia–reperfusion injury (CIRI)‐induced ferroptosis remains to be largely unrevealed. First, analysis differentially expressed genes CIRI based on GEO dataset GSE119121 revealed was upregulated CIRI. level prominently increased middle artery occlusion (MCAO)/reperfusion model oxygen–glucose deprivation/reoxygenation cell model....
T cell activation triggers metabolic reprogramming to meet increased demands for energy and metabolites required cellular proliferation. Ethanolamine phospholipid synthesis has emerged as a regulator of shifts in stem cells cancer cells, which led us investigate its potential role during activation. As selenoprotein I (SELENOI) is an enzyme participating two pathways the phosphatidylethanolamine (PE) plasmenyl PE, we generated SELENOI-deficient mouse models determine loss-of-function effects...
The Araliaceae family has significant economic and medicinal value. However, the phylogenetic relationships expression patterns of key genes active triterpenoid substance within this are still unclear. In study, we employed comparative transcriptomics to analyze transcriptomes 19 species from 11 genera Araliaceae, aiming elucidate evolutionary history in ginsenoside biosynthesis pathway. Our results divide into two subfamilies: Aralioideae Hydrocotyloideae. is further classified three...
Red ginseng (RG) and Trogopterus Feces (TF) are one of the drug pairs in “nineteen medicaments mutual antagonism” not recommended for compatibility Chinese Pharmacopoeia. In addition, RG functions to “tonify Qi” “nourish blood,” while TF can “promote blood circulation” “relieve pain”. Therefore, two drugs often combined treat stasis syndrome clinical practice traditional medicine (TCM). Nevertheless, application TCM formulas has attracted much attention but still lacks in‐depth research. To...
Abstract Background The difference in the prognoses between treatment with surgical therapy and continuation of local-plus-systemic following successful down-staging intermediate-advanced hepatocellular carcinoma (HCC) remains unclear. Methods Data 405 patients HCC treated at 30 hospitals across China from January 2017 to July 2022 were retrospectively reviewed. All received divided into (n = 100) nonsurgical groups 305) according whether they therapy. differences long-term 2 compared....
Abstract Growing evidence supports a general hypothesis that aging and cancer are diseases related to energy metabolism. However, the involvement of Fanconi Anemia (FA) signaling, unique genetic model system for studying human or cancer, in metabolism remains elusive. Here, we report FA complementation group D2 protein (FANCD2) functionally impacts mitochondrial ATP production through its interaction with ATP5α, whereas this relationship was not observed mutant FANCD2 (K561R)-carrying cells....
The mechanisms driving metabolic reprogramming during B cell activation are unclear, particularly roles for enzymatic pathways involved in lipid remodeling. We found that murine with lipopolysaccharide (LPS) led to a 1.6-fold increase total lipids included higher levels of phosphatidylethanolamine (PE) and plasmenyl PE. Selenoprotein I (SELENOI) is an ethanolamine phospholipid transferase the synthesis both PE PE, SELENOI expression was also upregulated activation. Selenoi knockout (KO)...
Elevated plasma total homocysteine (tHcy) level has been established as an independent risk factor for cardiovascular diseases. Danshensu, active ingredient of Salvia miltiorrhiza, shows wide benefit. However, in terms its own methylation, danshensu could elevate tHcy level, which would act against benefit, thus posing a 'therapeutic paradox'. As this paradox not fully assessed, we have evaluated the effects on levels to uncover underlying mechanisms. EXPERIMENT APPROACH: We influence (Hcy)...