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Melodie A. Williams-Aduja

ORCID: 0000-0002-4208-3495
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About
Contact & Profiles
A5022907590
Research Areas
  • Pancreatic function and diabetes
  • Lipid metabolism and biosynthesis
  • Aldose Reductase and Taurine

Hawaii Pacific University
 2021

 Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation
OPENALEX - Publications 
Chi Ma FuKun W. Hoffmann Michael P. Marciel Kathleen E. Page Melodie A. Williams-Aduja and 10 more Ellis N.L. Akana Greg S. Gojanovich Mariana Gerschenson Johann Urschitz Stefan Moisyadi Vedbar S. Khadka Sharon Rozovsky Youping Deng F. David Horgen Peter R. Hoffmann

T cell activation triggers metabolic reprogramming to meet increased demands for energy and metabolites required cellular proliferation. Ethanolamine phospholipid synthesis has emerged as a regulator of shifts in stem cells cancer cells, which led us investigate its potential role during activation. As selenoprotein I (SELENOI) is an enzyme participating two pathways the phosphatidylethanolamine (PE) plasmenyl PE, we generated SELENOI-deficient mouse models determine loss-of-function effects...

10.1016/j.molmet.2021.101170 article EN cc-by-nc-nd Molecular Metabolism 2021-01-20
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