A5047441348- Cytokine Signaling Pathways and Interactions
- S100 Proteins and Annexins
- Macrophage Migration Inhibitory Factor
- Neurological Disease Mechanisms and Treatments
- Medicinal Plant Pharmacodynamics Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease and Transplantation
- Phytochemical compounds biological activities
- Heme Oxygenase-1 and Carbon Monoxide
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Pharmacological Effects of Natural Compounds
- Biochemical effects in animals
- Organ Transplantation Techniques and Outcomes
- Advanced battery technologies research
- Phytochemistry and Biological Activities
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Fuel Cells and Related Materials
- Immune Response and Inflammation
- Biological Activity of Diterpenoids and Biflavonoids
- RNA regulation and disease
- ATP Synthase and ATPases Research
- Bioactive natural compounds
- Spinal Dysraphism and Malformations
Weifang Medical University
2019-2024
Southwest University of Science and Technology
2024
Jiangxi University of Traditional Chinese Medicine
2023-2024
Sun Yat-sen University Cancer Center
2021-2023
Sun Yat-sen University
2021-2023
Fujian Provincial Hospital
2023
Southwest Medical University
2022
Hainan University
2022
Central South University
2022
Wenzhou Medical University
2021
The mortality rate of sepsis remains high despite improvements in the diagnosis and treatment using symptomatic supportive therapies, such as anti-infection therapy fluid resuscitation. Nucleic acid-based drugs have therapeutic potential, although their poor stability low delivery efficiency hindered widespread use. Herein, it is confirmed that miR-223 can polarize proinflammation M1 macrophages to anti-inflammation M2 macrophages. A pH-sensitive nano-drug system comprising...
Toona sinensis (A. Juss.) Roem., which is widely distributed in China, a homologous plant resource of medicine and food. The leaves, seeds, barks, buds pericarps T. can be used as with traditional efficacy. Due to its extensive use the ancient world, has significant development potential. In this review, 206 compounds, including triterpenoids (1–133), sesquiterpenoids (134–135), diterpenoids (136–142), sterols (143–147), phenols (148–167), flavonoids (168–186), phenylpropanoids (187–192)...
Membrane with remarkable proton conductance and selectivity plays a key role in obtaining high vanadium flow battery (VFB) performance. In this work, the trade-off effect between ion blocking was overcome by introduction of cross-linking structure to prepare covalent cross-linked fluorine-containing sulfonated polyimide (CFSPI-PVA) membranes. Herein, CFSPI-PVA-15 membrane possesses excellent comprehensive properties, including acceptable area resistance (0.21 Ω cm2), lower permeability (0.76...
Microglia, neuron, and vascular cells constitute a dynamic functional neurovascular unit, which exerts the crucial role in recovery after ischemic stroke. Paeoniflorin, principal active component of Paeoniae Radix, has been verified to exhibit neuroprotective roles cerebralischemic injury. However, mechanisms underlying regulatory function Paeoniflorin on unit cerebral ischemia are still unclear.In this study, adult male rats were treated with following transient middle artery occlusion...
Asarum essential oil (AEO) has been shown to have good pharmacological activities for the anti-inflammatory and analgesic effects, but increasing dose may cause toxicity. Therefore, we studied toxic pharmacodynamic components of AEO by molecular distillation (MD). Anti-inflammatory activity was assessed using RAW264.7 cells. Neurotoxicity in PC12 cells overall toxicity evaluated mouse acute assay. The results showed that is primarily composed safrole, methyl eugenol, 3,5-dimethoxytoluene....
Hepatic ischemia-reperfusion injury (HIRI) is a complex process observed during liver resection and transplantation.
In order to investigate the mechnism of hepatoprotective N-acetyl-L-tryptophan (L-NAT) against ischemia-reperfusion (I/R) injury, effects L-NAT were investigated in hepatic injury (HIRI) models both vitro and vivo, which made by BRL cells Sprague-Dawley (SD) rats, respectively. The cell viability hepatocyte was assessed counting kit-8 (CCK-8) staining. activation autophagy detected electron microscopy (EM), quantitative real-time PCR (qRT-PCR), Western blotting immunofluorescence. mitophagy...
The objective of the present study was to identify chemical constituents volatile oil from Pyrolae herba (PHVO) and evaluate antiproliferative activity PHVO against SW1353 human chondrosarcoma cells. prepared by hydrodistillation characterized gas chromatography-mass spectroscopy (GC-MS). A total 12 components in were identified representing 81.62% integrated chromatographic peaks. major compounds found be n-hexadecanoic acid (29.29%), cedrol (17.08%), 6,10,14-trimethyl-2-pentadecanone...
The aim of this study was to investigate the changes TLR4/NLRP3 signal during hepatic ischemia-reperfusion injury (HIRI) and verify whether N-acetyl-L-tryptophan (L-NAT) protected hepatocytes by regulating activation signal. We have established rat HIRI model H 2 O -induced cell damage simulate detect corresponding indicators. Compared with sham group, Suzuki score level serum ALT increased after HIRI, accompanied an expression NLRP3, ASC, Caspase-1, IL-1β, TLR4, NF-κB. While L-NAT...
Curcumin has attracted much attention due to its wide range of therapeutic effects. In this study, we used serum collected from patients undergoing one-lung ventilation (OLV) establish an in vitro acute lung injury (ALI) model explore the potential protective mechanism curcumin on ALI. Our study provides a new reference for prevention and treatment ALI induced by OLV.A549 cells were treated with 20% OLV model. Curcumin, at dose 40 μg/ml, was administered two hours prior The levels...
Hepatic ischemia-reperfusion injury (HIRI) is one of the major sources mortality and morbidity associated with hepatic surgery. Ac2-26, a short peptide Annexin A1 protein, has been proved to have protective effect against IRI. However, whether it exerts on HIRI not reported. The mice model oxidative damage H 2 O -induced AML12 cells were established investigate Ac2-26 could alleviate by regulating activation IL-22/IL-22R1/STAT3 signaling. was measured various biochemical parameters related...
The synthesis of α-galactosylceramide (KRN7000) and its C-6 modified analogs remains a challenge due to the difficult α-1,2-cis-glycosidic bond. A non-participating benzyl (Bn) protecting group has been commonly used favor α-glycosylation product. Here, we report α-selective glycosylation by using bulky 4,6-O-di-tert-butylsilylene (DTBS) galactosyl donor, regardless 2-benzoyl (Bz) participating group. Compared with Bn, Bz groups can be selectively removed in basic conditions without...
Moxifloxacin (MXF) has been shown to possess immunomodulatory properties in addition its antimicrobial effects. We investigated the effects of MXF on cytokine secretion and signal transduction mechanisms naive control allergen-exposed airway smooth muscle cell (ASMC) stimulated with tumour necrosis factor (TNF)-α.An animal model was established. ASMC derived from rat tissue cultured vitro, then incubated 10 ng/mL TNF-α. Interleukin (IL)-8 eotaxin were measured by enzyme-linked immunosorbent...
To construct the active component-action target network diagram and protein-protein interaction(PPI) of Aurantii Fructus Immaturus volatile oil, so as to explore mechanism oil in treatment slow transit constipation(STC) by analyzing functions pathways involved target. The chemical constituents were determined gas chromatography-mass spectrometry(GC-MS). targets studied PubChem, TCMSP, STITCH Swiss Target Prediction. OMIM, Genecards-Search Resuits TTD used screen out Slow Transit...
Indian hedgehog (Ihh), one of the gene families, is indicated in regulation chondrocyte differentiation. Tougu Xiaotong formula (TXF), a traditional Chinese medicinal compound, has been used for treatment bone and joint disease. However, underlying molecular mechanisms TXF on function marrow stromal cells (BMSCs) remain unclear. In present study, affect proliferation chondrogenic differentiation was investigated primary BMSCs from four‑week‑old Sprague Dawley rats. The cell viability treated...