A5100685881- Gut microbiota and health
- Bat Biology and Ecology Studies
- Inflammatory Bowel Disease
- Soil Carbon and Nitrogen Dynamics
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Pharmacological Effects of Natural Compounds
- Air Quality and Health Impacts
- Glycogen Storage Diseases and Myoclonus
- MicroRNA in disease regulation
- Physiological and biochemical adaptations
- Food Security and Health in Diverse Populations
- Neurological disorders and treatments
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Diet and metabolism studies
- Anesthesia and Pain Management
- Climate Change and Health Impacts
- Parasites and Host Interactions
- Global Public Health Policies and Epidemiology
- Health disparities and outcomes
- Fluoride Effects and Removal
- Workaholism, burnout, and well-being
- Global Health Care Issues
- Machine Learning in Healthcare
Yunnan University
2022-2025
Jiangsu Province Hospital
2020-2025
Inner Mongolia Agricultural University
2025
Nanjing Maternity and Child Health Care Hospital
2025
Nanjing Medical University
2025
Wannan Medical College
2024
First Affiliated Hospital of Wannan Medical College
2024
Nanjing University of Chinese Medicine
2022-2024
Peking University
2024
National Clinical Research Center for Digestive Diseases
2024
Journal Article Does co-localization analysis reinforce the results of Mendelian randomization? Get access Qiuyuan Yin, Yin State Key Laboratory for Conservation and Utilization Bio-Resources in Yunnan, School Life Sciences, Yunnan University, Kunming 650500, China Search other works by this author on: Oxford Academic PubMed Google Scholar Lei Zhu Correspondence to: University Town, Chenggong District, E-mail: zhulei_evan@126.com Brain, Volume 147, Issue 1, January 2024, Pages e7–e8,...
Abstract Nonalcoholic fatty liver disease (NAFLD) encompasses a broad range of conditions, commencing with simple steatosis and progressing to non‐alcoholic steatohepatitis, the possibility further deterioration into fibrosis, cirrhosis, ultimately, hepatocellular carcinoma. Unfortunately, there is currently no approved medication for treating NAFLD‐associated steatosis. This underscores need improved therapeutic approaches that can modulate lipid metabolism halt transition from chronic...
Ulcerative colitis (UC) is a chronic and relapsing inflammatory disease of the intestine. Dysbiosis, especially expansion facultative anaerobic Enterobacteriaceae, maybe main pathogenesis UC. Gegen Qinlian decoction (GD), traditional Chinese medicinal formula chronicled in Shang Han Lun, commonly used to treat UC has shown an excellent effect on inducing remission. However, role GD regulating gut microbiota not been fully clarified. Herein, we investigated potential inhibiting...
Introduction Soil moisture and soil water retention capacity are key influencing factors for the normal growth development of vegetation. Understanding dynamic change characteristics in blowouts is great significance management blowouts. Methods This study employs drying situ monitoring methods to select typical different regions (sand pits, fringe zones, sand accumulation sand-grass transition zones) on Hulunbuir Grassland. A large area natural grassland surrounding these was chosen as...
Elucidating the gene regulatory mechanisms underlying gut–brain axis is critical for uncovering novel interaction pathways and developing therapeutic strategies gut bacteria-associated neurological disorders. Most studies have primarily investigated how bacteria modulate host epigenetics expression; their impact on alternative splicing, particularly in brain, remains largely unexplored. Here, we effects of gut-associated probiotic Lacidofil® splicing across 10 regions rat brain using...
ABSTRACT Industrialization has driven lifestyle changes in eastern and western Chinese populations, yet we have a poor understanding of the dynamic their gut microbiome resistome under industrialization, which is essential for scientific management public health. Here, this study employed metagenomics to analyze microbiota 1,382 healthy individuals from China, including 415 region advanced industrialization 967 developing industrialization. Compared with populations show significant increase...
Highlights•The amount of dopamine is positively correlated with circulating B cell numbers in humans•Dopamine activates antitumor responses via DRD5•Dopamine enhances through JAK1-STAT1 signaling•Combining the DRD5 agonist PD-1 antibody therapy elicited robust effectsSummaryNeuronal signals have emerged as pivotal regulators cells that regulate immunity and tumor progression. However, functional relevance mechanistic basis effects neurotransmitter (DA) on remain elusive. Here, we discovered...
Osteoporosis is a common degenerative bone disease. The treatment of osteoporosis remains clinical challenge in light the increasing aging population. Human dental pulp stem cells (DPSCs), type mesenchymal (MSCs), are easy to obtain and have high proliferation ability, playing an important role osteoporosis. However, MSCs undergo apoptosis within short time when used vivo; therefore, apoptotic vesicles (apoVs) attracted attention. Currently, osteogenic effect DPSC-derived apoVs unknown; this...
Background MicroRNAs (miRNAs) have pivotal roles in gene regulation. Circulating miRNAs been developed as novel candidate non-invasive biomarkers for diagnosis, prognosis, and treatment response diseases. However, that causal effects on Parkinson’s Disease (PD) remain largely unknown. To investigate the relationships between PD, here we conduct a Mendelian randomization (MR) study. Methods This study utilized summary-level data of respective genome-wide association studies (GWAS) 2083 seven...
Bats have an unusually large volume of endocrine tissue, with a population beta cells, and elevated sensitivity to glucose insulin. This makes them excellent animal models for studying diabetes mellitus. We evaluated bats as in terms lifestyle genetic factors. For factors, we generated data sets 149 body mass index (BMI) 860 forearm (FMI) measurements different species bats. Both showed negative inter-species correlations blood levels sixteen examined. The may reflect adaptation small...
Background: Baicalin is an important active flavonoid isolated from the roots of Scutellaria baicalensis (S. baicalensis), a well-known traditional Chinese herb used in treating inflammatory bowel disease (IBD). The objectives this study were to assess potential benefit baicalin experimental colitis, as well investigate metabolic biomarkers colitis conjunction with network pharmacology. Methods: Using widely utilized pharmacology technique, baicalin's targets and pathways predicted....
Several recent studies speculated that the gut microbiota is associated with sensorineural hearing loss (SNHL) and proposed concept of gut-inner ear axis. However, causal effect on SNHL still unknown. In this study, we performed a two-sample Mendelian randomization (MR) analysis to estimate SNHL.Gut data were obtained from largest available genome-wide association study (n = 18,340) conducted by MiBioGen consortium. The summary statistics FinnGen consortium R8 release (28,310 cases 302,750...
Proteolysis targeting chimeras (PROTACs) have shifted the paradigm for drug development via target protein degradation. However, PROTACs may exhibit systemic toxicity to normal cells due indiscriminate degradation and utility of inhibitors as a warhead targeting. Here, we propose new strategy developing activatable cell-specific histone deacetylase (HDAC) with minimal side effects caging warhead. Molecular docking reveals that hydroxyl group HDAC inhibitor is crucial An enzyme-activatable...
Apoptotic vesicles (apoVs) are apoptotic-cell-derived nanosized that take on dominant roles in regulating bone homeostasis. We have demonstrated mesenchymal stem cell (MSC)-derived apoVs promising therapeutic agents for regeneration. However, clinical translation of MSC-derived has been hindered due to expansion and nuclear substance. As another appealing source apoV therapy, blood cells could potentially eliminate these limitations. whether can release during apoptosis is uncertain, the...
Mammals developed antioxidant systems to defend against oxidative damage in their daily life. Enzymatic antioxidants and low molecular weight (LMWAs) constitute major parts of the systems. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2, encoded by Nrf2 gene) is a central transcriptional regulator, regulating transcription, many enzymes. Frugivorous bats eat large amounts fruits that contain high levels LMWAs such as vitamin C, thus, reliance on might greatly reduce need for enzymes...
Based on self-regulation theory, this study examines the relationship between job crafting, career identity, engagement, and turnover intention among hotel staff in China amid COVID-19 pandemic. This research draws observations of 1453 employees for its empirical data analysis by SPSS AMOS. Job crafting positively impacts identity engagement but negatively intention. The intentions are impacted their feelings engagement. Additionally, mediating role connection is further discussed...