A5043112848- Inflammatory Bowel Disease
- Gut microbiota and health
- Microscopic Colitis
- Pharmacological Effects of Natural Compounds
- Anorectal Disease Treatments and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Traditional Chinese Medicine Studies
- Mycobacterium research and diagnosis
- Pelvic floor disorders treatments
- Pregnancy and Medication Impact
- Effects and risks of endocrine disrupting chemicals
- Immune Cell Function and Interaction
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Metabolomics and Mass Spectrometry Studies
- Ginger and Zingiberaceae research
- Probiotics and Fermented Foods
- Herbal Medicine Research Studies
- Diagnosis and treatment of tuberculosis
- Colorectal Cancer Surgical Treatments
- Selenium in Biological Systems
- Medical Research and Treatments
- Circular RNAs in diseases
Nanjing University of Chinese Medicine
2017-2025
Jiangsu Province Hospital
2019-2023
ORCID
2021
Nanjing Medical University
2015-2020
Weatherford College
2020
Nanjing Children's Hospital
2015
Second Affiliated Hospital of Nanjing Medical University
2014
Patients with ulcerative colitis (UC) have a high prevalence of mental disorders, such as depression and anxiety. Gut microbiota imbalance disturbed metabolism been suggested to play an important role in either UC or disorders. However, little is known about their detailed multi-omics characteristics patients depression/anxiety. In this prospective observational study, 240 Chinese were enrolled, including 129 active (69 Phase 1 60 2; divided into depression/non-depression anxiety/non-anxiety...
Abstract Background and aims Ulcerative colitis (UC) is a metabolism-related chronic intestinal inflammatory disease. Disease extent key parameter of UC. Using serum metabolic profiling to identify non-invasive biomarkers disease may inform therapeutic decisions risk stratification. Methods The orthogonal partial least squares–discriminant analysis (OPLS-DA) was performed the metabolites. Least absolute shrinkage selection operator (LASSO) regression, random forest–recursive feature...
Dehydrocostus lactone (DL), one of the main active constituents in Aucklandia lappa Decne. (Muxiang), reported to have anti-inflammatory, antiulcer, and immunomodulatory properties. However, effect DL on ulcerative colitis (UC) has not been reported. To analyze anti-inflammatory potential role UC, we provide a mechanism for pharmacological action DL.The experimental model UC was induced by using oral administration 2% dextran sulfate sodium (DSS) with drinking water BALB/c mice. Mesalazine...
Ulcerative colitis (UC) is a chronic and relapsing inflammatory disease of the intestine. Dysbiosis, especially expansion facultative anaerobic Enterobacteriaceae, maybe main pathogenesis UC. Gegen Qinlian decoction (GD), traditional Chinese medicinal formula chronicled in Shang Han Lun, commonly used to treat UC has shown an excellent effect on inducing remission. However, role GD regulating gut microbiota not been fully clarified. Herein, we investigated potential inhibiting...
Approximately 20% of patients with ulcerative colitis become steroid dependent. Azathioprine is recommended in steroid-dependent colitis, but its side effects limit use. Chinese herbal medicine has been widely used to treat China. However, effectiveness not evaluated. This study aims investigate the efficacy traditional combination therapy 5-aminosalicylic acid colitis.This a parallel, multicenter, randomized controlled trial. One hundred and twenty eligible will be randomly assigned group...
Aim: This study aimed to determine whether nuclear factor erythroid 2-related 2 antagonized the oxidative stress induced by di- N-butylphthalate (DBP) in testicular Leydig cells. Methods: Mouse TM3 cells were treated with Nrf2 knockdown (KD) or overexpression presence and absence of DBP. Oxidative profiles examined. target antioxidant genes studied, effects inducer sulphoraphane (SFN) tested. Results: DBP intracellular a similar extent KD. Expression protein levels increased together its...
Abstract Background Hirschsprung's disease ( HSCR ) is one of the common digestive disorders in new born. Long non‐coding RNA s (lnc s) play an important role various biological processes. However, knowledge on lnc limited. Methods The expression profile was obtained using microarray. A total 2078 differentially expressed were detected by microarray tissues compared with matched normal colon (fold change ≥2, p < 0.05). Candidate biomarkers selected from these based artificial criterion...
Qing-Chang-Hua-Shi (QCHS) is a Chinese herbal formula, which composed of 11 herbs. Studies have also shown that QCHS granules can alleviate colitis in animal models by preventing inflammatory responses and suppressing apoptosis through the MEK/ERK signaling pathway. To determine efficacy safety patients with moderately active UC. We performed multicenter, randomized, placebo-controlled, double-blind study UC who did not respond to 4 weeks mesalazine therapy at maximum dose. Patients were...
Ulcerative colitis (UC) is a universal chronic nonspecific intestinal inflammatory disease of unknown etiology. Although 5-aminosalicylic acid (5-ASA) used as first-line treatment for mild-to-moderate UC, some patients do not react well to it. Traditional Chinese medicine (TCM) plays complementary role in the management UC. A large number randomized controlled trials (RCTs) have shown that TCM has significant effect However, due diversity treatments, its relative effectiveness and safety...
Abstract Background: Hemorrhoidal disease (HD) is one of the commonest proctologic condition in general population. Medical therapy for HD has not been formally confirmed due to inconsistent results. Liang-Xue-Di-Huang Decoction, a kind ancient Chinese classical prescription, used treat from 19th century China. However, clinical research Decoction treatment was lack. We designed this study evaluate efficacy and safety HD. Methods/Design: A randomized, controlled, double blind, double-mimetic...
<title>Abstract</title> <bold>Background</bold>: Ulcerative colitis (UC) is a metabolic-related chronic intestinal inflammatory disease. Disease extent an intrinsic aspect of UC and influences the treatment modality. Identifying serum metabolic profiling different disease may help to elucidate underlying molecular mechanisms UC. <bold>Methods</bold>: patients with healthy controls were included in this study. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method detected...
Background and Objectives: Ulcerative Colitis (UC) subtypes defined by disease extent shared pathophysiology are important. Analyzing the clinical characteristics of UC with different optimizing typing conducive to pathogenesis research, monitoring precise treatment. Methods: 188 patients active were divided into distal extensive colitis. The two groups analyzed propensity score. Spearman is used for correlation analysis, receiver operating characteristic (ROC) curve was evaluate ability...
Abstract Background Ulcerative colitis (UC) is an intestinal inflammatory disease characterized by inflammation of the colonic mucosa. With unknown pathogenesis, it has become a chronic lifetime disorder worldwide. In patients with moderately active UC, several therapies (e.g., aminosalicylates, corticosteroids, immunosuppressants, and biologics) are recommended for induction (or maintenance) remission. Given side effects burden, difficult most to achieve ideal treatment goals in clinical...
Abstract Background: Ulcerative colitis (UC) is an intestinal inflammatory disease characterized by inflammation of the colonic mucosa. With unknown pathogenesis, it has become a chronic lifetime disorder worldwide. In patients with moderately active UC, several therapies (e.g. aminosalicylates, corticosteroids, immunosuppressants and biologics) are recommended for induction (or maintenance) remission. Given side effects burden, difficult most to achieve ideal treatment goals in clinical...
Abstract Background: Hemorrhoidal disease (HD) is one of the commonest proctologic condition in general population. Medical therapy for HD has not been formally confirmed due to inconsistent results. Liang-Xue-Di-Huang Decoction, a kind ancient Chinese classical prescription, used treat from 19th century China. However, clinical research Decoction treatment lack. We designed this study evaluate efficacy and safety HD. Methods/Design: A randomized, controlled, double blind, double-mimetic...
Abstract Background: Hemorrhoidal disease (HD) is one of the commonest proctologic condition in general population. Medical therapy for HD has not been formally confirmed due to inconsistent results. Liang-Xue-Di-Huang Decoction, a kind ancient Chinese classical prescription, used treat from 19th century China. However, clinical research Decoction treatment lack. We designed this study evaluate efficacy and safety HD. Methods/Design: A randomized, controlled, double blind, double-mimetic...
Abstract Background:Ulcerative colitis (UC) patients have a high incidence of mental disorders. The microbiota-gut-brain axis dysfunction is considered as one important pathogenesis diseases. At present, little known about how gut microbiota interact with the host in UC depression and anxiety.Results: This prospective observational study enrolled 240 Chinese two cohorts: discovery cohort, including 69 active patients, 49 non-inflammatory bowel disease (IBD) anxiety 62 healthy people,...
Abstract Background: Hemorrhoidal disease (HD) is one of the commonest proctologic condition in general population. Medical therapy for HD has not been formally confirmed due to inconsistent results. Liang-Xue-Di-Huang Decoction, a kind ancient Chinese classical prescription, used treat from 19th century China. However, clinical research Decoction treatment lack. We designed this study evaluate efficacy and safety HD. Methods/Design: A randomized, controlled, double blind, double-mimetic...