A5101824771- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Cryospheric studies and observations
- Climate change and permafrost
- Cancer Research and Treatments
- Complex Network Analysis Techniques
- Climate variability and models
- Environmental Changes in China
- Opinion Dynamics and Social Influence
- Gene Regulatory Network Analysis
- Hydrology and Watershed Management Studies
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Electrical Contact Performance and Analysis
- Meteorological Phenomena and Simulations
- Environmental and Agricultural Sciences
- Epigenetics and DNA Methylation
- Remote Sensing and Land Use
- RNA modifications and cancer
- Fire effects on ecosystems
- Neural Networks Stability and Synchronization
- Air Quality and Health Impacts
- Liver physiology and pathology
- Geology and Paleoclimatology Research
- Railway Engineering and Dynamics
Zhejiang University
2012-2025
Zhejiang University of Science and Technology
2015-2024
China Meteorological Administration
2021-2024
First Affiliated Hospital of Wannan Medical College
2022-2024
Shandong Marine Resource and Environment Research Institute
2024
Second Military Medical University
2023
Central South University
2023
Second Xiangya Hospital of Central South University
2023
Eastern Hepatobiliary Surgery Hospital
2023
Shandong Jiaotong University
2022
Abstract Gasdermin-E (GSDME), the executioner of pyroptosis when cleaved by caspase 3, plays a crucial role in tumor defense and response to chemotherapy drugs cells. So far, there are poorly known mechanisms for expression regulation GSDME during cell death. Here, we identify transcription factor Sp1 (Specificity protein 1) as positive regulator GSDME-mediated pyroptosis. directly interacts with promoter at −36 ~ −28 site promotes gene transcription. Further, knockdown or inhibition...
者认为正源是当曲 [1] ; 澜沧江(出国境后称为湄公河)正 源为扎阿曲, 发源于青海省玉树藏族自治州杂多县扎 青乡的果宗木查山.此3条水系发源地合称为三江源 区 , 其 中 黄 河 、
Nonalcoholic fatty liver disease (NAFLD) is one of the most common diseases which lacks ideal treatment options. Kaempferol and kaempferide, two natural flavonol compounds isolated from Hippophae rhamnoides L., were reported to exhibit a strong regulatory effect on lipid metabolism, for mechanism largely unknown. In present study, we investigated effects kaempferol kaempferide oleic acid (OA)-treated HepG2 cells, widely used in vitro model NAFLD. The results indicated an increased...
Abstract In this study, the spatiotemporal distributions of monthly and annual temperature minima (T min ) maxima max ), extreme T , highest (lowest) frost day (FD), icing (ID), summer (SD) tropical night (TR) at 112 stations over ten large river basins on Tibetan Plateau its surroundings (TPS) during 1963–2015 are examined. Mann-Kendall test is applied for trends. The analyses show: northwest experiences hottest while central TPS has coldest winter most frequent days. (southeast) features...
The Yarlung Tsangpo Basin (YB) on the Tibetan Plateau. Characteristics and changes of air temperature, precipitation, snow cover, depth, glacier, streamflow during 1979–2015, land cover/use in 1990 2015, responses to are analyzed. objective is understand major factors that influence YB at both intra-annual inter-annual time scales. experiences significant warming but spatiotemporally varying precipitation changes. Snow decreases glaciers retreat with heterogeneous spatial patterns....
Patients with type 1 diabetes (T1D) and 2 (T2D) present intestinal disturbances. Recent epidemiological data have showed that, worldwide, over half of newly diagnosed T1D patients were adults. However, the gut microbial alterations in adult-onset are unclear. We aimed to identify signatures microbiota metabolites systematically, comparing T2D healthy controls (HCs).
The translocation of YAP from the cytoplasm to nucleus is critical for its activation and plays a key role in tumor progression. However, precise molecular mechanisms governing nuclear import are not fully understood. In this study, we have uncovered crucial SOX9 YAP. promotes by direct interaction. Importantly, identified that binding between Asp-125 Arg-124 essential SOX9-YAP interaction subsequent entry Additionally, discovered novel asymmetrical dimethylation at (YAP-R124me2a) catalyzed...
The dropper is one of the core components high speed railway catenary and failure will lead to serious transportation accidents. It very important carry out defect detection. There are a large number droppers installed in catenary. images collected by high-definition camera on top moving inspection vehicles. image quality consistency poor, it difficult identify defects automatically. department companies lack efficient intelligent detection methods. This article innovatively proposes...
Abstract Investigating the changes in extreme temperature indices is crucial for assessment of climate change and to recommend practical adaptation strategies particularly countries like Nepal, which highly prone impacts climatic events. This study analyses mean temperatures at 25 stations located different physiographic regions Nepal monthly annual time scales 1986–2015. Ten recommended by ETCCDI are selected examined. Quality control first conducted original daily maximum minimum data. In...
Climate change (CC) and land use/cover (LUCC) are the main drivers of streamflow change. In this study, effects CC LUCC on regime as well their spatial variability were examined by using Distributed Hydrology Soil Vegetation Model (DHSVM) for Beichuan River Basin in northeast Tibetan Plateau. The results showed that increased annual maximum upstream but decreased them downstream. also enhanced minimum whole river basin advanced occurrence daily streamflow. Temperature exerted greater...
Based on the hourly visibility data, and its changes during 2010–2020 at monthly annual time scales over 47 international airports in China are investigated, nine artificial-intelligence-based prediction models trained (hourly data 2018–2019) tested 2020) these airports. The analyses show that of eastern central is a poor level all year round, LXA (in Lhasa) has good round. Airports south northwest have better from May to October poorer November April. In months, increasing mainly occurs...
Frozen soil properties and thermohydraulic processes are still not fully understood due to lack of in-situ measurements, especially in the high altitudes latitudes (HAHL). Based on hourly measurements at 10, 40, 80 120 cm depths 21 sites west, south northeast regions Tibetan Plateau (TP) during July 2018 - 2019, we examined particles, spatiotemporal variations their connections with environmental factors reveal heterogenous frozen TP. Sand silt dominant particles clay is less than 10% sites....
Endoscopic ultrasonography (EUS) is recommended as the best tool for evaluating gastric subepithelial lesions (SELs); nonetheless, it has difficulty distinguishing gastrointestinal stromal tumors (GISTs) from leiomyomas and schwannomas. GISTs have malignant potential, whereas schwannomas are considered benign.This study aimed to establish a combined radiomic model based on EUS images in stomach.EUS of pathologically confirmed GISTs, leiomyomas, were collected five centers. Gastric SELs...
Abstract Osteoclasts are over-activated as we age, which results in bone loss. Src deficiency mice leads to severe osteopetrosis due a functional defect osteoclasts, indicating that function is essential osteoclasts. G-protein-coupled receptors (GPCRs) the targets for ∼35% of approved drugs but it still unclear how GPCRs regulate kinase activity. Here, reveal GPR54 activation by its natural ligand Kisspeptin-10 (Kp-10) causes Dusp18 dephosphorylate at Tyr 416. Mechanistically, Gpr54 recruits...
Based on daily precipitation data from 115 climate stations, seasonal and annual their extremes over the Tibetan Plateau its surroundings (TPS) in 1963–2015 are investigated. There exists a clear southeast-northwest gradient extreme but an opposite pattern for consecutive dry days (CDDs). The wet southeast is trending while center northwest 1963–2015. Correspondingly, there drying tendency basins wetting semi-dry summer, which will affect water resources corresponding areas. increase...
Abstract Background: The pharmacokinetic and clinical behaviors of many proton pump inhibitors (PPIs) in peptic ulcer treatment are altered by CYP2C19 genetic polymorphisms. This non-inferiority study evaluated the efficacy safety novel PPI anaprazole compared with rabeprazole. We also explored influence Helicobacter pylori ( H. ) infection status polymorphism on anaprazole. Methods: In this multicenter, randomized, double-blind, double-dummy, positive-drug parallel-controlled, phase III...
Atmospheric conditions, topsoil properties and land cover conditions play essential roles in ground surface temperature (GST), air (SAT) their differences (GST-SAT). They determine the strength of thermal forcing lower atmospheric boundary distributions frozen cold regions. However, relative importance these factors at various time scales underlying physical mechanisms remain less well understood. Here, we investigate spatiotemporal patterns GST-SAT examine 11 potential three categories...
Abstract The means and changes of annual monthly wind speed their extremes over the Tibetan Plateau its surroundings (TPS) in 1970–1999, 2000–2005 2006–2015 are investigated. correlations between eight atmospheric circulation indices variables also investigated for possible mechanisms change region. study shows that strongest appears during February–June, whereas weakest October–January. Weak extreme concentrates southern Gansu, central Sichuan, western Yunnan, near boarders Qinghai,...