A5082164179- interferon and immune responses
- Cancer, Lipids, and Metabolism
- Inflammasome and immune disorders
- Cancer, Hypoxia, and Metabolism
- Toxoplasma gondii Research Studies
- Metabolomics and Mass Spectrometry Studies
Duke Kunshan University
2024
Soochow University
2022
Second Affiliated Hospital of Soochow University
2022
Abstract Gasdermin-E (GSDME), the executioner of pyroptosis when cleaved by caspase 3, plays a crucial role in tumor defense and response to chemotherapy drugs cells. So far, there are poorly known mechanisms for expression regulation GSDME during cell death. Here, we identify transcription factor Sp1 (Specificity protein 1) as positive regulator GSDME-mediated pyroptosis. directly interacts with promoter at −36 ~ −28 site promotes gene transcription. Further, knockdown or inhibition...
Objective: To observe the lipid metabolism characteristics of tumor-associated macrophages (TAM) after malignant transformation in glioma micro-environment, and analyze biological phenotype changes regulatory mechanisms inhibiting remodeling. Methods: Twelve male Balb/c mice 6-8 weeks were used study. Macrophages (Mφ) derived from mouse bone marrow, malignantly transformed (tMφ1 tMφ2) cloned model stem cell (GSC) through interaction with Mφ vivo vitro. Intracellular droplet formation...