A5048259771- Sepsis Diagnosis and Treatment
- RNA modifications and cancer
- Cardiac Arrest and Resuscitation
- RNA Research and Splicing
- Respiratory Support and Mechanisms
- Resilience and Mental Health
- Posttraumatic Stress Disorder Research
- RNA regulation and disease
- Nitric Oxide and Endothelin Effects
- Diabetes Management and Research
- Abdominal Surgery and Complications
- Immune Response and Inflammation
- Thermal Regulation in Medicine
- Computational Drug Discovery Methods
- Pancreatitis Pathology and Treatment
- Mitochondrial Function and Pathology
- Pneumonia and Respiratory Infections
- Adipose Tissue and Metabolism
- Disaster Response and Management
- Trauma and Emergency Care Studies
- Clinical Nutrition and Gastroenterology
- Healthcare professionals’ stress and burnout
- Appendicitis Diagnosis and Management
- Metabolism, Diabetes, and Cancer
- Ferroptosis and cancer prognosis
Shanghai Tenth People's Hospital
2013-2025
Tongji University
2013-2025
Guangzhou University of Chinese Medicine
2025
University of Illinois Urbana-Champaign
2015-2016
University of Illinois Chicago
2015-2016
Illinois College
2015-2016
To investigate the predictive value of C-reactive protein (CRP) to serum albumin (ALB) ratio in severity and prognosis acute pancreatitis (AP), compare CRP/ALB with Ranson score, modified computed tomography index (MCTSI) Bedside Index Severity Acute Pancreatitis (BISAP) score.This cohort study retrospectively analyzed clinical data AP patients from August 2018 2020 our hospital. Logistic regression analysis was utilized determine effects ratio, Ranson, MCTSI, BISAP score on severe (SAP),...
Mechanical ventilation is clinically used to assist in the gas exchange for patients who need maintain adequate alveolar ventilation. Its common indications include respiratory failure, heart drug overdose, and surgery. Although mechanical can save lives of with prolonged use lead diaphragm atrophy contraction dysfunction. Currently, there a lack effective assessment monitoring methods dysfunction clinical practice, leading insufficient attention function. Understanding pathophysiological...
Purpose Adult body shape index (ABSI) is widely recognized as a reliable indicator for evaluating fat distribution and dysfunction. However, the relationship between ABSI Klotho protein, known its anti-aging biological function, has not yet been investigated. Therefore, aim of this study was to assess correlation serum levels in adults residing United States. Methods A cross-sectional participants conducted based on 2007–2016 National Health Nutrition Examination Survey. Visceral adiposity...
Abstract Purpose The choice of continuous renal replacement therapy (CRRT) anticoagulation program for patients at high risk bleeding has always been a complex problem in clinical practice. Clinical regimens include regional citrate (RCA) and nafamostat mesylate (NM). This study aimed to evaluate the efficacy safety these two anticoagulants CRRT guide their use better. Patients methods Between January 2021 December 2022, 307 were screened this study. Forty-six finally enrolled: 22 group 24...
Abstract Introduction Malnutrition is a frequent problem associated with detrimental clinical outcomes in critically ill patients. To avoid malnutrition, most studies focus on the prevention of inadequate nutrition delivery, whereas little attention paid to potential role exocrine pancreatic insufficiency (EPI). In this trial, we aim evaluate prevalence EPI and identify its risk factors adult patients without preexisting diseases. Methods prospective cross-sectional study, recruited 563...
Background Sepsis stands as a dire medical condition, arising when the body’s immune response to infection spirals into overdrive, paving way for potential organ damage and mortality. With intestinal flora’s known impact on sepsis but dearth of comprehensive data, our study embarked two-sample Mendelian randomization analysis probe causal link between gut microbiota their metabolites with severe patients who succumbed within 28-day span. Methods Leveraging data from Genome-wide association...
Whether the AutoPulse automated chest compression device is worthy of clinical use for out-of-hospital cardiac arrest (OHCA) remains controversial. A prospective controlled study was conducted to evaluate effect versus manual cardiopulmonary resuscitation (CPR) OHCA patients in northern district Shanghai, China.A total 133 with who were treated at Emergency Medical Center Tenth People's Hospital Affiliated Tongji University between March 2011 and 2012 included. The randomly assigned Manual...
Background: The alarming mortality rate of sepsis in ICUs has garnered significant attention. precise etiology remains elusive. Mitochondria, often referred to as the cellular powerhouses, have been postulated a dysfunctional role, correlating with onset and progression sepsis. However, exact causal relationship be defined. Method: Employing Mendelian randomization approach, this study systematically analyzed data from IEUOpenGWAS UKbiobank databases concerning mitochondrial function-related...
BackgroundInfluenced by socio-cultural and world events, Chinese society has significant intergenerational differences. With rapid economic cultural development, the unique characteristics of Generation Z nursing students in China may influence clinical education environment. However, research on is still its infancy.ObjectivesThis study aimed to explore experiences perceptions during their practicum an intensive care unit (ICU) context China's historical background.MethodsA phenomenological...
Objectives This study aims to investigate the post-traumatic growth of emergency nurses (ENs) in Shanghai, China, 2022 following COVID-19 pandemic. Design A phenomenological qualitative research approach was employed, with 17 ENs being interviewed between July and August 2022. Data collection conducted through semistructured, in-depth interviews, data analysis carried out using Colaizzi’s seven-step method. Setting third-level hospital Shanghai. Participants total were face-to-face,...
Background: Kallistatin (KS) is a serine proteinase. The result of KS on 'Renal Ischemia- Reperfusion Injury' (IRI) has not clearly been researched. In this study, investigative research conducted to draw results the administration human kidney response within mouse model IRI. Materials and Methods: BALB/c mice were used given 30 min ischemia that was injected into which followed with 24 h reperfusion. gene contained an adenoviral vector intravenously before reperfusion 12h after Analyses...
Aim: Tumor protein p53 (TP53) mutant is one of the most frequently mutated genes in glioma. Results: The Cancer Genome Atlas data has shown that TP53 mutation present 49% lower grade (World Health Organization [WHO] grades II and III) glioma patients. Data from Genomics Drug Sensitivity database showed three drugs: (5Z)-7-oxozeaenol, dabrafenib nutlin-3a (−), have more resistance patients with mutation. We identified 1100 differentially expressed genes. Functional enrichment analysis are...
Noninvasive monitoring of intra-abdominal pressure (IAP) by measuring abdominal wall tension (AWT) was effective and feasible in previous postmortem animal studies. This study aimed to investigate the feasibility AWT method for noninvasively IAP intensive care unit (ICU).In this prospective study, we observed patients with detained urethral catheters ICU Shanghai Tenth People's Hospital between April 2011 March 2013. The correlation urinary bladder (UBP) analyzed linear regression analysis....
Endothelial nitric oxide synthase (eNOS) is responsible for maintaining systemic blood pressure, vascular remodeling and angiogenesis. Previous studies showed that bovine eNOS serine 1179 (Serine 1177 human eNOS) phosphorylation enhanced NO synthesis. Meanwhile, heat shock protein 90 (Hsp90) plays a critical role in maintenance of structure function. However, the regulatory difference importance between Serine Hsp90 on activity have not been evaluated. In current studies, S1179D was employed...
ObjectiveThe previous coronavirus disease 2019(COVID-19) epidemic inflicted significant psychological trauma on emergency and critical care nurses due to various factors, potentially leading job burnout. Despite the rise of positive psychology, little is known about post-traumatic growth experience these after pandemic. The aim this study was assess among nurses, in order provide managerial insights for developing effective strategies facilitating transformation nurses' negative emotions...
<h3>BACKGROUND:</h3> The objective was to study the level of monocyte-human leukocyte antigen-DR (mHLA-DR), an immune function-related biomarker, at 24 h after admission, predict outcomes subjects with severe pneumonia. <h3>METHODS:</h3> Subjects community-acquired pneumonia (<i>n</i> = 102) were included in study. Blood samples collected from each subject admission. Data regarding age, sex, P<sub>aO<sub>2</sub></sub>/F<sub>IO<sub>2</sub></sub>, comorbidities, occurrence altered mental...