A5103255504- Esophageal Cancer Research and Treatment
- Virus-based gene therapy research
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- MicroRNA in disease regulation
- Rabies epidemiology and control
- Animal Virus Infections Studies
- Lung Cancer Diagnosis and Treatment
- Municipal Solid Waste Management
- Brain Metastases and Treatment
- Renal Diseases and Glomerulopathies
- RNA Research and Splicing
- Cancer-related gene regulation
- Plant Molecular Biology Research
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Virology and Viral Diseases
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Chromium effects and bioremediation
- Bacillus and Francisella bacterial research
- Aldose Reductase and Taurine
- Viral Infections and Immunology Research
- Electromagnetic wave absorption materials
- Concrete Properties and Behavior
Shanghai Dianji University
2024
Jiangsu Cancer Hospital
2007-2022
Nanjing Medical University
2012-2022
MetroHealth Medical Center
2022
Case Western Reserve University
2022
Henan Radio and Television University
2021
University of Kentucky
2018-2020
Xi'an Chest Hospital
2020
Southern Methodist University
2017-2018
Soochow University
2018
We report genome-wide single-base resolution maps of methylated cytosines and transcriptome change in Cd-exposed rice. Widespread differences were identified CG non-CG methylation marks between Cd-free rice genomes. There are 2320 non-redundant differentially regions detected the genome. RNA sequencing revealed 2092 DNA methylation-modified genes expressed under Cd exposure. More found hypermethylated than those hypomethylated CG, CHH CHG (where H is A, C or T) contexts upstream, gene body...
<h3>Importance</h3> Most older patients with esophageal cancer cannot complete the standard concurrent chemoradiotherapy (CCRT). An effective and tolerable regimen for is needed. <h3>Objective</h3> To evaluate efficacy toxic effects of CCRT S-1 vs radiotherapy (RT) alone in cancer. <h3>Design, Setting, Participants</h3> A randomized, open-label, phase 3 clinical trial was conducted at 23 Chinese centers between June 1, 2016, August 31, 2018. The study enrolled 298 aged 70 to 85 years....
Hexavalent chromium [Cr(VI)] is a common environmental carcinogen causing lung cancer in humans. This study investigates the mechanism of Cr(VI) carcinogenesis focusing on role epitranscriptomic dysregulation. The effect was determined Cr(VI)-transformed human bronchial epithelial cells, chromate-exposed mouse and lungs. its Cr(VI)-induced cell transformation, stem (CSC)-like property, tumorigenesis were by microarray analysis, soft agar colony formation, suspension spheroid xenograft...
Hexavalent chromium [Cr(VI)] is one of the most common environmental carcinogen causing lung cancer in humans; however, mechanism Cr(VI) carcinogenesis remains elusive. Cancer stem cells (CSCs) are considered as initiating and maintaining cells. Ours other recent studies showed that chronic exposure induces CSC-like property representing an important carcinogenesis. However, how largely unknown. In this study, we found stably knocking down expression c-Myc, a proto-oncogene key stemness...
The molecular mechanisms associated with rabies virus (RV) virulence are not fully understood. In this study, the RV Flury low-egg-passage (LEP) and high-egg-passage (HEP) strains were used as models to explore attenuation mechanism of RV. results our studies confirmed that R333Q mutation in glycoprotein (G(R333Q)) is crucial for mice. stably maintained HEP genome background but LEP during replication mouse brain tissue or cell culture. Further investigation using chimeric viruses revealed...
Our previous in vitro studies suggested that cyclic AMP (cAMP) signaling prevents adriamycin (ADR) and puromycin aminonucleoside (PAN)-induced apoptosis podocytes. As cAMP is an important second messenger plays a key role cell proliferation, differentiation cytoskeleton formation via protein kinase A (PKA) or exchange directly activated by (Epac) pathways, we sought to determine the of PKA Epac cAMP-mediated protection In ADR nephrosis model, found forskolin, selective activator adenylate...
Abstract Esophageal carcinoma is aggressive in nature and its prognosis largely dependent on the degree of invasion. Histone deacetylase 6 (HDAC6), as most unique member HDACs family, has positive activity to promote initiation progression various cancers via targeting multiple non‐histone proteins cytoplasm. In this study, we found that HDAC6 was over‐expressed three esophageal cancer cell lines (KYSE140, KYSE170, KYSE180) when compared non‐carcinoma epithelial HEEC‐1. Then two specific...
Abstract Chronic hexavalent chromium [Cr(VI)] exposure causes lung cancer and other types of cancer; however, the mechanism Cr(VI) carcinogenesis remains to be clearly defined. Our recent study showed that chronic upregulates proto oncogene c-Myc expression, which contributes significantly Cr(VI)-induced cell transformation, stem (CSC)-like property tumorigenesis. is a master regulator abnormal metabolism accumulating evidence suggests dysregulation plays an important role in both...
The rabies Flury Low Egg Passage virus (LEP) has been widely used as a seed to generate inactive vaccine. Here, we established reverse genetic system for LEP and generated recombinant (rLEP-G) that carries two identical G genes. This showed similar properties those of with respect in vitro growth, neurotropism index, virulence mice. rLEP-G produced 4.3-fold more protein than did BHK-21 cells. inactivated vaccine from induced significantly higher neutralization titers mice dogs response...
The aim of this study was to assess if the entire mediastinum (M), bilateral supraclavicular area (S), and left gastric (L) should be all included in irradiation volume. clinical data 204 patients with thoracic esophageal squamous cell carcinoma who had undergone prophylactic postoperative radiotherapy after radical surgery were retrospectively reviewed. They classified into four groups: group A, 26 irradiated M alone; B, 139 + S; C, 10 L; D, 29 S L. 5-year disease-free survival rates 36%...
Background: The People's Republic of China has the largest population affected by osteoporosis in world. However, no population-based survey awareness been reported. This study investigated level basic a large community China. relationship between and quantitative ultrasound (US) measurements at calcaneus was also assessed. Methods: A questionnaire completed 9983 men women aged 40 years or older Nanjing, China, June December 2011. During this time, participants underwent US measurement. Data...
The current study aimed to investigate the function of Hedgehog pathway and its association with epithelial-mesenchymal transition (EMT) in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance non-small cell lung cancer (NSCLC). Lung tumor tissue specimens from EGFR TKI-resistant patients, including those brain metastases, had hyperactive signaling compared TKI-sensitive patients. SHH stimulation promoted GLI1 activation as well motility parental PC9 cells while...
Autophagy inhibition is crucial for the improvement of efficacy radiotherapy in cancer. The aim present study was to determine potential therapeutic value autophagy and its correlation with mitochondria human esophageal carcinoma cells following treatment ionizing radiation (IR). Eca‑109 induced under poor nutrient conditions. formation autophagic vacuoles monitored using electron microscopy. In addition, cell apoptosis after IR mitochondrial membrane (MMP) were analyzed by flow cytometry....
Abstract To examine the outcomes of concurrent versus sequential whole-brain radiotherapy (WBRT) and epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) in nonsmall cell lung cancer (NSCLC) patients with EGFR mutation. Retrospectively 105 NSCLC, brain metastasis, mutation (Affiliated Hospital Guangdong Medical University, 01/2011 to 12/2014) were grouped as: EGFR-TKIs alone (n = 39, group A), + 34, B), followed by 32, C). The intracranial objective response rates groups A,...
The optimal radiation dose for patients with esophageal squamous cell carcinoma (ESCC) has long been debated. We undertook the retrospective study to evaluate survival impact of high vs standard in stage II-III cancer treated definitive chemoradiotherapy (CRT).A total 137 were included our study, 63 classified as standard-dose group and 74 high-dose group. For group, median PFS 1-, 2-, 3-year rates 12.6 months, 58.0%, 26.0% 12.0%, respectively; they 20.0 80.1%, 31.0% 20.0%, respectively (P =...