A5027833675- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Polymer Surface Interaction Studies
- Virus-based gene therapy research
- Nanoparticle-Based Drug Delivery
- Surface Modification and Superhydrophobicity
- Click Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Silk-based biomaterials and applications
- Bacteriophages and microbial interactions
- Dendrimers and Hyperbranched Polymers
- Anesthesia and Neurotoxicity Research
- Chemical Synthesis and Analysis
- Bone Tissue Engineering Materials
- Supramolecular Chemistry and Complexes
- Coenzyme Q10 studies and effects
- Biopolymer Synthesis and Applications
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
Wuhan University
2014-2022
The University of Melbourne
2017-2019
Severe side effects of cancer chemotherapy prompt developing better drug delivery systems. Injectable hydrogels are an effective site-target system. For most injectable hydrogels, once delivered in vivo, some properties including release and degradation, which critical to chemotherapeutic safety, challenging monitor. Developing a system for therapy with vivo real-time noninvasive trackability is highly desired. Although fluorescence dyes used imaging the cytotoxicity limits their...
The manipulation of interfacial properties has broad implications for the development high-performance coatings. Metal-phenolic networks (MPNs) are an emerging class responsive, adherent materials. Herein, host-guest chemistry is integrated with MPNs to modulate their surface and properties. Macrocyclic cyclodextrins (host) conjugated catechol or galloyl groups subsequently used as components assembly functional MPNs. assembled cyclodextrin-based highly permeable (even high molecular weight...
En route to target cells, a gene carrier faces multiple extra- and intracellular hurdles that would affect delivery efficacy. Although diverse strategies have been proposed functionalize carriers for individually overcoming these barriers, it is challenging generate single multifunctional capable of surmounting all barriers. Aiming at this challenge, we developed supramolecular modular approach fabricate cationic system. It consists two prefunctionalized modules: (1) host module: polymer...
Novel pH and reduction dual-sensitive biodegradable polymeric micelles for efficient intracellular delivery of anticancer drugs were prepared based on a block copolymer methyloxy-poly(ethylene glycol)-b-poly[(benzyl-l-aspartate)-co-(N-(3-aminopropyl) imidazole-l-aspartamide)] [mPEG-SS-P(BLA-co-APILA), MPBA] synthesized by combination ring-opening polymerization side-chain reaction. The pH/reduction-responsive behavior MPBA was observed both dynamic light scattering UV–vis experiments....
Novel reduction degradable and photosensitive disulfide-containing azobenzene-terminated branched poly(2-(dimethylamino)ethyl methacrylate)s (Az-ss-BPDMs) supramolecular host-guest self-assembly systems with poly(cyclodextrin) (PCD) were prepared evaluated as non-viral gene delivery vectors. The light dual sensitive properties of the polycations PCD/Az-ss-BPDMs their polyplexes PCD/Az-ss-BPDMs/DNA confirmed by UV-Vis, SEC, DLS zeta potential analyses, respectively. It was shown that...
ABSTRACT A novel kind of graft polymer poly(aspartic acid)‐ethanediamine‐ g ‐adamantane/methyloxy polyethylene glycol (Pasp‐EDA‐ ‐Ad/mPEG) was designed and synthesized for drug delivery in this study. The chemical structure the prepared confirmed by proton NMR. obtained can self‐assemble into micelles which were stable under a physiological environment displayed pH‐ β‐cyclodextrin (β‐CD)‐responsive behaviors because acid‐labile benzoic imine linkage hydrophobic adamantine groups side chains...
Multifunctional host–guest supramolecular PCD-acetal-PGEA/Ad-PEG-FA polyplexes showing FA-targeting and acid-triggered intracellular gene release resulted in good transfection efficiency low cytotoxicity.
ABSTRACT Biodegradable amphiphilic ABC Y‐shaped triblock copolymer (MPBC) containing PEG, PBLA, and PCL segments was synthesized via the combination of enzymatic ring‐opening polymerization (ROP) epsilon‐caprolactone, ROP BLA‐ N ‐carboxyanhydride click chemistry, where are poly(ethylene glycol), poly(benzyl‐ l ‐aspartate), polycaprolactone, respectively. Propynylamine employed as initiator for preparation alkynyl‐terminated PBLA methyloxy‐PEG with hydroxyl azide groups at chain‐end used...
Abstract The manipulation of interfacial properties has broad implications for the development high‐performance coatings. Metal–phenolic networks (MPNs) are an emerging class responsive, adherent materials. Herein, host–guest chemistry is integrated with MPNs to modulate their surface and properties. Macrocyclic cyclodextrins (host) conjugated catechol or galloyl groups subsequently used as components assembly functional MPNs. assembled cyclodextrin‐based highly permeable (even high...
Reduction degradable Pasp-SS-CD/Ad<sub>4</sub>-PEI/pDNA supramolecular nanoparticles <italic>via</italic> host–guest interaction exhibited improved cellular internalization and higher gene transfection efficiency with lower cytotoxicity.
Biodegradable and thermosensitive polyaspartamide derivatives containing pendant azide groups P(Asp-Az)X-HPAs were synthesized from poly(l-succinimide) via the ring-opening reaction with 2-azidoethylamine (Az) 5-hydroxypentylamine (HPA). Then hydrophobic phenethyl (PEA) imidazole (IMZ) moieties introduced successfully very high efficiency above 90% to side chains of P(Asp-Az)X-HPA by click obtain thermoresponsive aromatic rings P(Asp-Az)X-HPA-PEAs thermo/pH-responsive P(Asp-Az)X-HPA-IMZs,...
It is very challenging to fabricate a non-viral gene carrier system containing multifunctional components overcome multiple extra- and intracellular barriers. Herein, we developed novel PEGylated, targeted fluorescence traceable supramolecular host-guest vector system. This was based on poly(β-cyclodextrin) (PCD), disulfide-containing azobenzene-terminated branched polymer (Az-ss-BPDM-RhB) with rhodamine-fluorescent functional groups adamantyl terminated folate-modified PEG (Ad-PEG-FA)....