A5101564614- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Airway Management and Intubation Techniques
- Surgical Simulation and Training
- Augmented Reality Applications
- Neonatal Respiratory Health Research
- Trauma Management and Diagnosis
- Pneumonia and Respiratory Infections
- Anatomy and Medical Technology
- Photodynamic Therapy Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Research Studies
- Respiratory Support and Mechanisms
- Enhanced Recovery After Surgery
- Myasthenia Gravis and Thymoma
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
First Affiliated Hospital of Guangzhou Medical University
2015-2024
Guangzhou Medical University
2015-2024
State Key Laboratory of Respiratory Disease
2016-2024
Zero to Three
2022
Shantou Central Hospital
2022
National Clinical Research Center for Digestive Diseases
2016-2019
Tianjin International Joint Academy of Biomedicine
2018
Nankai University
2018
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2018
Washington University in St. Louis
2018
Optimal treatment for resectable esophageal squamous cell carcinoma (ESCC) is controversial, especially in the context of potential benefit combining PD-1 blockade with neoadjuvant therapy. This phase 2 study aimed to assess camrelizumab plus chemotherapy this population. Patients (clinical stage II-IVA) received two cycles chemoimmunotherapy (NIC) (200 mg on day 1) nab-paclitaxel (260 mg/m2 total 1 and 8) cisplatin (75 days 1-3) each 21-day cycle. Surgery was performed approximately 6 weeks...
Accumulation of myofibroblasts is critical to fibrogenesis in idiopathic pulmonary fibrosis (IPF). Senescence and insufficient mitophagy fibroblasts contribute their differentiation into myofibroblasts, thereby promoting the development lung fibrosis. Bone morphogenetic protein 4 (BMP4), a multifunctional growth factor, essential for early stage development; however, role BMP4 modulating remains unknown.The aim this study was evaluate using BMP4-haplodeleted mice, BMP4-overexpressed primary...
Abstract Chronic obstructive pulmonary disease (COPD) is a chronic, progressive, and lethal lung with few treatments. Formononetin (FMN) clinical preparation extract extensive pharmacological actions. However, its effect on COPD remains unknown. This study aimed to explore the underlying mechanisms of FMN COPD. A mouse model was established by exposure cigarette smoke (CS) for 24 weeks. In addition, bronchial epithelial BEAS‐2B cells were treated CS (CSE) h in vitro FMN. significantly...
Problems associated with intubation, chest drainage and urinary catheterization can have a negative impact on patient's recovery after thoracic surgery. We therefore evaluated the feasibility of new tubeless (spontaneous ventilation without tracheal catheterization, no post-operative drain placement) approach to perform video-assisted thoracoscopic surgery (VATS) for small pulmonary nodules (SPN) less than 2cm in diameter.From 1 January 2012 31 December 2014, 34 patients SPNs were treated...
This study aims to explore the feasibility and safety of video-assisted thoracic surgery (VATS) double sleeve lobectomy in patients with non-small lung cell cancer (NSCLC).Between June 2012 August 2014, 13 NSCLC underwent thoracoscopic mediastinal lymphadenectomy at three institutions. A retrospective analysis clinical characteristics, operative data, postoperative events follow-up was performed.Thirteen (median age, 60 years; range, 43-67 years) lobectomy. There were no conversions...
Hydrogen sulfide (H2S), an endogenous gaseous signal molecule, regulates many pathologies related to aging. Sirtuin 1 (SIRT1) has been shown protect against mitochondrial dysfunction and other pathological processes, including premature senescence. This study was aimed investigate whether how H2S attenuates senescence apoptosis of alveolar epithelial cells via a SIRT1-dependent mechanism. Our results showed that treatment with sodium hydrosulfide (NaHS), donor H2S, attenuated cigarette smoke...
MicroRNAs are a class of small endogenous non-coding RNAs that play crucial roles in the initiation and progression human cancers. miR-186 was found decreased various malignancies function as tumor suppressor. However, regulating mechanism growth metastasis non-small cell lung cancer (NSCLC) is still poorly understood. We investigated role NSCLC. In present study, we significantly tissues cells. Furthermore, overexpression suppressed proliferation, migration invasion, induced apoptosis....
Abstract Andrographolide (Andro), a component from Chinese medicinal herb Andrographis paniculata , could alleviate pulmonary fibrosis in rodents. Yet, whether and how Andro mitigates epithelial‐mesenchymal transition (EMT) induced by TGF‐β1 remain unknown. This study aimed to explore the effect of on TGF‐β1‐induced EMT human alveolar epithelial cells (AECs) mechanisms involved. We illustrated that inhibited EMT‐related transcription factors A549 cells. also reduced cell migration synthesis...
We report a case of video-assisted thoracoscopic surgery (VATS) tracheal resection and carinal reconstruction in patient with tumor. The presented adenoid cystic carcinoma (ACC) the distal trachea, extending along right main bronchus invasion. procedure was assisted cross-field ventilation. Postoperative clinical course this good. forced expiratory volume first second (FEV1) improved from 0.461 L (17% pred.) to 2.31 (87% 1 month after operation. VATS is feasible option for patients tumor...
Abstract: Trans-sternal thymectomy has long been accepted as the standard surgical procedure for thymic masses. Recently, minimally invasive methods, such video-assisted thoracoscopic surgery (VATS) and, even more recently, non-intubated anesthesia, have emerged. These methods provide advantages including reductions in trauma, postoperative associated pain, and regards to VATS, certain cosmetic benefits. Considering these advantages, we herein present a case of subxiphoid uniportal VATS mass...
Andrographolide (Andro), a diterpenoid extracted from Andrographis paniculata, has been shown to attenuate pulmonary fibrosis in rodents; however, the potential mechanisms remain largely unclear. This study investigated whether and how Andro alleviates bleomycin (BLM)-induced NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation epithelial-mesenchymal transition (EMT) lung epithelial cells.The vivo effects of were evaluated rat model BLM-induced fibrosis. The...
To investigate the impact of prolonged length stay (LoS) on long-term mortality in patients who have undergone curative resection for esophageal cancer (EC).
Abstract: The conventional two-dimensional (2D) and glasses-assisted three-dimensional (3D) display systems can no longer meet the clinical requirements with development of minimally invasive video-assisted thoracoscopic surgery (VATS). glasses-free 3D technology adopts both lenticular lens face-tracking -positioning offers high brightness, large viewing area, strong anti-interference capability, which significantly improve operator's experience. When applied in VATS, it has many advantages...
4028 Background: Despite multidisciplinary therapies, prognosis of pts with resectable esophageal squamous cell carcinoma (ESCC) remains poor. Combining PD-1 blockade to neoadjuvant chemotherapy might be a feasible and effective strategy. Camrelizumab (an anti-PD-1 antibody) was approved for advanced or metastatic ESCC in the second-line setting showed improved anti-tumor activity survival benefit when combined multiple tumors. Methods: In this NIC-ESCC2019 phase 2 study, histologically...
Abstract Few predictive biomarkers exist for identifying patients who may benefit from neoadjuvant therapy (NAT). The intratumoral microbial composition is comprehensively profiled to predict the efficacy and prognosis of with esophageal squamous cell carcinoma (ESCC) underwent NAT curative esophagectomy. Least Absolute Shrinkage Selection Operator (LASSO) regression analysis conducted screen most closely related microbiota develop a microbiota‐based risk prediction (MRP) model on genera...