A5045684734- Analytical chemistry methods development
- Geochemistry and Elemental Analysis
- Cancer, Hypoxia, and Metabolism
- Terahertz technology and applications
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Lichen and fungal ecology
- Organ Transplantation Techniques and Outcomes
- Extraction and Separation Processes
- Heavy metals in environment
- Geology and Paleoclimatology Research
- Conducting polymers and applications
- Renal Transplantation Outcomes and Treatments
- Cancer-related molecular mechanisms research
- Spectroscopy and Laser Applications
- Glioma Diagnosis and Treatment
- Electrochemical sensors and biosensors
- Physics of Superconductivity and Magnetism
- melanin and skin pigmentation
- Advanced Chemical Sensor Technologies
- Plant Genetic and Mutation Studies
- Organ Donation and Transplantation
- Fuel Cells and Related Materials
- Monoclonal and Polyclonal Antibodies Research
- Plant Stress Responses and Tolerance
North China Institute of Aerospace Engineering
2024
Sinovac Biotech
2024
Hefei National Center for Physical Sciences at Nanoscale
2021-2023
Hunan Provincial People's Hospital
2021-2023
University of Science and Technology of China
1999-2023
Hunan Normal University
2021-2023
Chinese Academy of Agricultural Sciences
2020-2021
Institute of Bast Fiber Crops
2020-2021
Fujian Normal University
2020
National Synchrotron Radiation Laboratory
2019-2020
Use of the dioxin toxic equivalency factor (TEF) approach in human risk assessments assumes that combined effects dioxin-like compounds a mixture can be predicted based on potency-adjusted dose-additive combination constituents mixture. In this study, we evaluated TEF experimental 2-year rodent cancer bioassays with female Harlan Sprague-Dawley rats receiving 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3,3 ,4,4 ,5-pentachlorobiphenyl (PCB-126), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), or...
Previous research from this laboratory using a continuous enteral ethanol (EtOH) administration model demonstrated that Kupffer cells are pivotal in the development of EtOH-induced liver injury. When were destroyed gadolinium chloride (GdCl3) or gut was sterilized with polymyxin B and neomycin, early inflammation due to EtOH blocked. Anti-tumour necrosis factor (TNF)-alpha antibody markedly decreased injury increased TNF-mRNA. These findings led hypothesis involves increases circulating...
The role of oxidants in the mechanism tumor promotion by peroxisome proliferators remains controversial. idea that induction acyl-coenzyme A oxidase leads to increased production H<sub>2</sub>O<sub>2</sub>, which damages DNA, seems unlikely; still, free radicals might be important signaling specialized cell types such as Kupffer cells, produce mitogens. Because hard evidence for oxidant vivo after treatment with is lacking, spin-trapping technique and electron spin resonance spectroscopy...
Large language models have demonstrated impressive performance on challenging mathematical reasoning tasks, which has triggered the discussion of whether is achieved by true capability or memorization. To investigate this question, prior work constructed benchmarks when questions undergo simple perturbations -- modifications that still preserve underlying patterns solutions. However, no explored hard perturbations, fundamentally change nature problem so original solution steps do not apply....
Histone deacetylase inhibitors (HDACi) have shown potential as an epigenetic therapy in various cancer treatments. However, its application the treatment of skin melanoma faces challenge drug resistance. This article reviews resistance mechanism HDACi melanoma, analyzes action HDACi, characteristics and solutions to resistance, aiming provide reference for further melanoma.
Epoxide within molecular structures is recognized as hallmarks of potent carcinogenic cells. This paper proposes a novel approach: Magnetic Resonance Therapy (MRT), which selectively eliminates epoxide in cancerous tissues while preserving oxygen healthy tissues, offering potentially side-effect-free method for cancer treatment and prevention. The study presents series vitro, vivo, clinical experiments to support this innovative therapeutic strategy. underlying mechanism MRT grounded the...
Immunohistochemical detection of prostate specific antigen (PSA) is widely used to identify metastatic prostatic adenocarcinoma. However, PSA may not be expressed in some poorly differentiated carcinomas and its immunoreactivity has been found non-prostatic tissues. P501s (prostein) a prostate-specific marker that the cytoplasm benign malignant glandular cells. It detected any other normal or The purpose this study was evaluate expression adenocarcinoma compare with PSA.Immunohistochemical...
Angiomyolipoma with epithelial cysts (AMLEC) is a recently described distinct cystic variant of angiomyolipoma (AML). To date 15 cases AMLEC have been reported in 2 case series. We report the 16th 39-year-old female. Her left kidney tumor was discovered incidentally. Partial nephrectomy performed. Histologically, composed three components: 1) lined by cuboidal to hobnail cells; 2) compact subepithelial mullerian-like AML stroma admixed chronic inflammation; and 3) muscle-predominant...
In this work, we propose a method for distinction of edible oils by using terahertz (THz) spectrum combined with chemometrics.
Flavonoids are a large class of polyphenols widely distributed in plants the free form or as glycosides, and they have antioxidation, antibacterial, antitumor growth, other pharmacological effects. As an important active component traditional Chinese medicine, high medicinal value development prospects. In this work, biomolecular properties 10 common flavonoids, including baicalein, baicalin, apigenin, quercetin, naringenin, hesperetin, daidzein, genistein, puerarin, gastrodin, studied by...
Cell-mediated immune responses are crucial in the protection against tuberculosis. In this study, we constructed epitope DNA vaccines (p3-M-38) encoding cytotoxic T lymphocyte (CTL) epitopes of MPT64 and 38 kDa proteins Mycobacterium order to observe influence spacer sequence (Ala-Ala-Tyr) or ubiquitin (UbGR) on efficacy two CTL epitopes, also vaccines, p3-M-S(spacer)-38, p3-Ub (UbGR)-M-S-38 p3-Ub-M-38. The elicited by four were tested C57BL/6 (H-2b) mice. cytotoxicity cells was detected...
Summary Objective Multiple endocrine neoplasia type 2 is caused by autosomal dominant gain‐of‐function mutations in the RET proto‐oncogene, which includes multiple 2A (MEN2A), 2B (MEN 2B), and familial medullary thyroid carcinoma (FMTC). In this paper we present phenotype–genotype correlation of 20 unrelated Chinese families with 15 cases MEN2A five MEN2B. Design Cross‐sectional study. Patients A total 147 members from were included. Among them, 119 family pedigrees (including probands) 28...
Purpose: This study was meant to analyze immune infiltration and construct a ceRNA network explore the new therapeutic targets for atopic dermatitis (AD) through bioinformatics way. Patients Methods: We downloaded AD patients’ RNA expression profile datasets (GSE63741, GSE124700) from Gene Expression Omnibus (GEO) database, which were analyzed GEO2R. explored hub genes by enrichment analysis protein–protein interaction (PPI) analysis. Moreover, we estimated cell types their proportions...
The concentration of ultratrace rare earth elements (REEs) in tea was accurately determined by inductively coupled plasma mass spectrometry (ICP-MS), based on microwave digestion for sample preparation and AG50W-x8 cation-exchange chromatography separation REEs from the matrix. spectroscopic interferences matrix-induced polyatomic ions BaO+, BaOH+ with Eu+ were eliminated. application potential method evaluated analysis Certified Reference Materials Tea (GSV-4) Bush Twin Leaf (GSV-2). A good...
The current shortage of transplantable organs has renewed interest in kidneys obtained from non-heartbeating donors. Kidneys these donors have suffered warm ischemia (WI). effectiveness two preservation solutions, i.e., the University Wisconsin (UW) and histidine tryptophan ketoglutarate (HTK) for that been subjected to WI was tested dogs. left kidney autotransplanted after 30 min WI, subsequent 24-hr cold storage (CS) either UW (n=6) or HTK (n=6), with immediate contralateral nephrectomy....