A5100451745- melanin and skin pigmentation
- Skin Protection and Aging
- Antimicrobial Resistance in Staphylococcus
- Genomics, phytochemicals, and oxidative stress
- Bacterial biofilms and quorum sensing
- Telomeres, Telomerase, and Senescence
- Dermatology and Skin Diseases
- Contact Dermatitis and Allergies
- Cancer-related molecular mechanisms research
- Attachment and Relationship Dynamics
- Reproductive System and Pregnancy
- Dietary Effects on Health
- Click Chemistry and Applications
- Hong Kong and Taiwan Politics
- Impact of Technology on Adolescents
- Analytical chemistry methods development
- Chromium effects and bioremediation
- Hair Growth and Disorders
- Cancer Immunotherapy and Biomarkers
- Retinal and Optic Conditions
- MicroRNA in disease regulation
- Circadian rhythm and melatonin
- Biosensors and Analytical Detection
- Biochemical and Structural Characterization
- Healthcare and Venom Research
Central People's Hospital of Zhanjiang
2024
Hunan Normal University
2006-2023
Hunan Provincial People's Hospital
2017-2023
Zhongnan Hospital of Wuhan University
2020-2022
Wuhan University
2020-2022
Shanghai Jiao Tong University
2020
Hunan First Normal University
2020
State Key Laboratory of Oncogene and Related Genes
2020
Renji Hospital
2020
Weifang People's Hospital
2020
The long-term impact of COVID-19 on the mental health and well-being college students, specifically trends over time after full removal restrictions, has not been well-studied.
Skin aging is often accompanied by disruption of circadian rhythm and abnormal expression rhythm-related genes. In this study, we downloaded skin datasets from the GEO database utilized bioinformatics machine learning methods to explore genes pathways involved in aging, revealing pathological molecular mechanisms aging. Results showed that 39 (CRGs) were identified these CRGs enriched signaling such as glucagon pathway, insulin resistance, thyroid hormone adipocytokine pathway. Three key...
DNA methyltransferase 1 (DNMT1) is a major epigenetic regulator associated with many biological processes. However, the roles and mechanisms of DNMT1 in skin aging are incompletely understood. Here we explored role human fibroblasts senescence its related regulatory mechanisms. expression decreased passage-aged silencing young induced phenotype. MiR-217 predicted to target mRNA miR-217 increased fibroblasts. directly targeted 3'-untranslated region (3'-UTR) HEK 293T cells inhibited...
In patients with dermatitis, the sudden discontinuation of topical corticosteroid (TC) use after long-term treatment could cause flaring symptoms (named "rebounding responses"). Diagnostic criteria for facial corticosteroid-dependent dermatitis (FCDD) are vague and uncertain. We aim to define a category clinical rebounding triad including severe itching, dryness burning. Patients FCDD (n = 268) were evaluated determine distinctive manifestations TC cessation. Data on history presentations...
Staphylococcus aureus (S. aureus) constantly evolves under host and environment pressures. The monitoring network is essential in assessing the epidemiology of S. infections. A total 555 isolates were collected from five hospitals three different geographical regions China for investigation molecular characteristics, antibiotic resistance, virulence gene, wall teichoic acid (WTA) glycosyltransferase gene profiles. 233 (42.0%) identified as MRSA, 323 (58.2%) defined multidrug-resistant (MDR)...
Staphylococcus aureus (S. aureus) can cause a broad spectrum of diseases ranging from skin infections to life-threatening in both community and hospital settings. The surface-exposed wall teichoic acid (WTA) has strong impact on host interaction, pathogenicity, horizontal gene transfer, biofilm formation S. aureus. unusual ST630 strains containing ribitol-phosphate (RboP) WTA glycosyltransferase tarM glycerol-phosphate (GroP) tagN have been found recently. Native PAGE analysis showed that...
Purpose: This study aimed to investigate the molecular characteristics, antimicrobial resistance and virulence genes profiles of S. aureus isolates from Wuhan, central China. Materials Methods: A total 302 non-duplicate were collected successively during January–December 2018 subjected multi-locus sequence typing (MLST), staphylococcal protein ( spa ) Panton–Valentine leucocidin (PVL) enterotoxin A, B, C, D, E, G, H I sea, seb, sec, sed, see, seg, seh sei detection. All methicillin-resistant...
Secretory pathway calcium ATPase 1 (SPCA1) is a pump localized specifically to the Golgi. Its effects on UVA-induced senescence have never been examined. In our study, expression of SPCA1 was increased in UVA-irradiated human dermal fibroblasts (HDFs) by activating mitogen-activated protein kinase (MAPK) and its downstream transcription factor, c-jun. Dual-luciferase reporter chromatin immunoprecipitation assays revealed that c-jun regulated binding promoter. Furthermore, downregulating with...
Leeches are frequently used in traditional Chinese medicine. However, they potentially hazardous to human and animal health by transmitting several pathogens. Studies of diseases transmitted leeches scarce. The purpose this study was analyze the pathogens carried pond-farmed medicinal leech China. were collected from 6 farms Hubei Province central DNA extracted internal organ origin blood meal. Leech genera confirmed through amplification 18S rRNA mitochondrial gene cytochrome oxidase I...
Parental attachment has been argued to play a fundamental role in the development of adolescent Internet morality. However, little is known about mediating and moderating mechanisms parental attachment. The present study tested moderated mediation model that included (predictor variable), empathy (moderator), online social support (mediator), morality (outcome variable) sample 2178 participants aged 12–25 years (Mage = 19.61, SD 2.39) recruited school setting. After controlling for gender,...