A5034455677- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Aluminum Alloy Microstructure Properties
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Landslides and related hazards
- Bone Metabolism and Diseases
- Hepatitis C virus research
- Endoplasmic Reticulum Stress and Disease
- Military Defense Systems Analysis
- Insect-Plant Interactions and Control
- Growth Hormone and Insulin-like Growth Factors
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Gout, Hyperuricemia, Uric Acid
- Cardiovascular Function and Risk Factors
- Microstructure and mechanical properties
- Inflammasome and immune disorders
- Additive Manufacturing Materials and Processes
- NF-κB Signaling Pathways
- Mycorrhizal Fungi and Plant Interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Artificial Intelligence in Healthcare
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Kunming University of Science and Technology
2016-2025
First People's Hospital of Yunnan Province
2015-2025
Chongqing University of Posts and Telecommunications
2023-2024
Harbin Institute of Technology
2023-2024
Shenyang University of Technology
2024
Northeast Agricultural University
2022-2023
Chinese Academy of Agricultural Sciences
2023
Ministry of Agriculture and Rural Affairs
2023
Zhengzhou Fruit Research Institute
2023
Foshan Maternity and Child Health Care Hospital
2023
Introduction Early screening for diabetic retinopathy (DR) with an efficient and scalable method is highly needed to reduce blindness, due the growing epidemic of diabetes. The aim study was validate artificial intelligence-enabled DR investigate prevalence in adult patients diabetes China. Research design methods prospectively conducted at 155 centers A non-mydriatic, macula-centered fundus photograph per eye collected graded through a deep learning (DL)-based, five-stage classification....
BACKGROUND The lack of specific predictors for type-2 diabetes mellitus (T2DM) severely impacts early intervention/prevention efforts. Elevated branched-chain amino acids (BCAAs: Isoleucine, leucine, valine) and aromatic (AAAs: Tyrosine, tryptophan, phenylalanine)) show high sensitivity specificity in predicting animals predict T2DM 10-19 years before onset clinical studies. However, improvement is needed to support its utility. AIM To evaluate the effects body mass index (BMI) sex on...
Chlamydiae, a diverse group of obligate intracellular pathogens replicating within cytoplasmic vacuoles eukaryotic cells, are able to acquire lipids from host cells. Here we report that activation the Raf-MEK-ERK-cPLA2 signaling cascade is required for chlamydial uptake glycerophospholipids. Both MAP kinase pathway (Ras/Raf/MEK/ERK) and Ca(2+)-dependent cytosolic phospholipase A2 (cPLA2) were activated in chlamydia-infected The inhibition cPLA2 activity resulted blockade glycerophospholipids...
2219 Al alloy is widely used in the aerospace industry owing to its outstanding properties. In this study, we evaluated effects of extrusion temperature and ratio on microstructure mechanical properties extruded specimens, including changes during post-extrusion aging. range 380–500 °C, bar after at 470 °C were best. Furthermore, ratios up 25:1 produced rods with excellent microstructure. Increasing increased dissolution eutectic θ phase solid solution accelerated breakage inclusions...
Objective Diabetes mellitus is a chronic condition that requires constant blood glucose monitoring to prevent serious health risks. Accurate prediction essential for managing fluctuations and reducing the risk of hypo- hyperglycemic events. However, existing models often face limitations in horizon accuracy. This study aims develop hybrid deep learning model combining Transformer Long Short-Term Memory (LSTM) networks improve accuracy extend horizon, using personalized patient information...
The diabetic autonomic neuropathy is one of the most common complications in type 2 diabetes mellitus (T2DM), especially gastrointestinal (GAN), which occurs up to 75% patients. study aimed investigate gut microbiota composition, structure, and function T2DM patients with GAN (T2DM_GAN) set a link between clinical characteristics patients.DNA was extracted from fecal samples three groups using kit method: healthy volunteers (n = 19), 76), T2DM_GAN 27). Sequencing 16S ribosomal DNA performed...
Alzheimer's disease (AD) is one of the most frequent diseases in elderly people and causes high mortality. Its incidence increasing annually no effective therapeutic treatment currently exists. In present study, salidroside, a major active ingredient Rhodiola rosea, was able to protect PC‑12 cells from toxicity apoptosis induced by AD inducer amyloid (A)β1‑42. Salidroside significantly protected inhibiting Aβ1‑42‑induced cytotoxicity mitochondria‑mediated endogenous caspase apoptotic...
Introduction: The outbreak of coronavirus disease has negatively impacted college students' mental health across the world. In addition, substance abuse also is trouble among these students. This study aims to find gender difference in Chinese international and during COVID-19 pandemic. Method: We conducted an online survey using PHQ-9, GAD-7, several questions related frequency, self-injury, suicidal thoughts, 535 male 475 female students whose ages ranged from 18 23 years old ( x = 20.19,...
Abstract Chlamydia trachomatis, an obligate intracellular bacterial species, is known to inhibit host cell apoptosis. However, the chlamydial antiapoptotic mechanism still not clear. Because NF-κB activation antiapoptotic, we tested potential role of in activity current study. First, no obvious was detected chlamydia-infected cells when these were resistant apoptosis induced via either intrinsic or extrinsic pathways. Second, inhibition with pharmacologic reagents failed block activity....
Introduction Phytoremediation is an effective strategy for saline land restoration. In the Western Songnen Plain, northeast China, soil fungal community recovery phytoremediation has not been well documented among different cropping patterns. this study, we tested how rotation, mixture, and monoculture patterns impact communities in saline-alkali soils to assess variability between Methods The of types were determined using Illumina Miseq sequencing. Results Mixture rotation promoted...
The application of Ericoid mycorrhizal (ErM) fungi is considered to be an important strategy for increasing plant yield and drought resistance. In this study, we isolated identified two ErM that can promote the growth lingonberry. We tried understand potential these lingonberry strategies help plants cope with water shortage. use value was evaluated by inoculating Oidiodendron maius FC ( Om FC) or Lachnum pygmaeum ZL6 Lp ZL6), well-watered (WW) severe stress (SDS). results showed mycelium...
Abstract Mosquitoes and mosquito-borne illnesses significantly impact public health human well-being. To address this concern, environmentally compatible larvicides have become a critical component of integrated mosquito management. However, the number available is at historical low. Currently, that harness microbials insect growth regulators account for most products. Screening new active ingredients (AIs) or improvement existing AIs thus necessary to augment capacity control. S-methoprene...
Abstract Postmenopausal osteoporosis (PMOP) is a common disease that endangers the health of elderly women. Cucumber seeds have shown excellent therapeutic effects on PMOP, but mechanism cucumber seed peptide (CSP) remains unclear. The expression levels NF-κB and osteoclast-related genes were detected by RT-qPCR. apoptosis-related proteins Western blotting. Nuclear translocation p65 osteoclast formation immunofluorescence tartrate-resistant acid phosphatase (TRAP) staining, respectively....
Current studies have shown that type I or II interferon-modified mesenchymal stem cells great potential for the application of tumor-targeted therapy, but underlying mechanism remains largely elusive. Here, we compared different effects IFN-β and IFN-γ on antitumor activity human amniotic fluid-derived (AFMSCs) revealed mechanism. In detail, AFMSCs primed with plus IFN-γ, not inhibited proliferation cancer in an immunocompetent mouse H460 subcutaneous model, although they all...
Wire arc additive manufacturing technology of 7050 aluminum alloy has a broad application prospect in aerospace field. But the lack comprehensive properties caused by coarse columnar grains and pores becomes an important bottleneck. In this study, hot compression is conducted to simulate forging process investigate microstructure improvement as‐deposited Al plastic deformation. The effect temperature at 390–540 °C deformation 20%–60% on porosity revealed. results, only slip occurs 420 below....
7075 aluminum alloy is widely used in the aerospace field because of its low density, high specific strength, fracture toughness, and good machinability. Herein, evolution microstructure properties at different temperatures systematically studied. Based on rolling heat treatment process, a short process proposed, which can significantly improve properties. The study finds that nanophases are distributed “streamline‐like” or “lip‐like” shape after rolling. When temperature below 550 °C,...
Brain network provides an essential perspective for studying normal and pathological brain activities. Reconstructing the in source space becomes more needed, example, as a target non-invasive neuromodulation. Precise estimating activities from scalp EEG is still challenging because it ill-posed question of volume conduction effect. There no consensus on how to reconstruct network. This study uses simultaneous stereo-EEG investigate effect inverse solutions, connectivity measures, node sizes...
Type 1 diabetes mellitus (T1DM) is well-known to trigger a disruption of lipid metabolism. This study aimed compare profile changes in T1DM patients after achieving glucose control and explore the underlying mechanisms. In addition, we seek identify novel biomarkers associated with under conditions glycemic control. A total 27 adults (age: 34.3 ± 11.2 yrs) who had maintained for over year, 24 healthy controls 35.1 + 5.56 were recruited. Clinical characteristics all participants analyzed...
Background and Purpose Type 2 diabetes mellitus patients have an increased fracture risk despite having higher areal bone mineral density (aBMD) measured by DXA. This apparent paradox might be explained the overestimation of BMD DXA due to fat mass in type patients. Volumetric (vBMD) as assessed quantitative CT (QCT) is not influenced mass. We association vBMD fasting plasma glucose a large cohort Chinese subjects compared healthy diabetic subjects. In addition, we relation between aBMD,...
Abstract Purpose The pathogenesis of Graves’ orbitopathy/thyroid-associated orbitopathy (TAO) is still unclear, and abnormal DNA methylation in TAO has been reported. Thus, selecting exploring biomarkers associated with may provide a reference for new therapeutic targets. Methods TAO-associated expression data were downloaded from Gene Expression Omnibus database. Firstly, weighted gene co-expression network analysis was used to obtain the TAO-related genes, which intersected differentially...
Diabetic cardiomyopathy is a subset of heart disease that directly associated with diabetes, and left ventricular diastolic dysfunction the earliest sign. We aimed to investigate association between sex differences function in patients type 2 diabetes.This was cross-sectional study included diabetes who visit National Metabolic Management Center (MMC) at First People's Hospital Yunnan from 2018 2021. Patients hypertension, history or ejection fraction <50% were excluded study. Logistic...
Type 2 diabetes is a well described extra-hepatic manifestation of hepatitis C virus (HCV) infection. This study aimed to explore the potential mechanism KCNQ1 overlapping transcript 1 (KCNQ1OT1) in type mellitus (T2DM) caused by HCV infection.Min6 cells were infected with establish vitro model, and copy number was detected real-time quantitative PCR (RT-qPCR). The mRNA protein expressions IL-1β, IL-18, NLRP3, caspase-1, GSDMD analyzed RT-qPCR Western blot. Flow cytometry TUNEL assay used...
Trichothiodystrophy nonphotosensitive 1 (TTDN1) is a disease with mental retardation, brittle hair. Some cases of the diseases are caused by mutations MPLKIP gene. We carefully identified clinic characteristics, sulfur level and pattern hair shafts female patient symptom hypergonadotropic hypogonadism, her parents brother whose healthy. also collected blood sample performed exon sequencing. One G insertion in was after analyzing obtained sequencing profile. The sites patient, brother, were...
Mitogen‑activated protein kinase (MAPK) signal transduction pathways may be involved in the destruction of pancreatic islet β cells induced by inflammatory cytokines. The present study aimed to investigate role different MAPK interleukin‑1β (IL‑1β)‑induced inhibition glucose‑stimulated insulin secretion (GSIS) Min6 mouse cells. were stimulated with concentrations glucose (0.0, 5.5, 11.1 and 22.2 mmol/l), or IL‑1β (0.00, 0.25 2.50 ng/ml) combination high (22.2 mmol/l) culture supernatant was...