Objective Diabetes mellitus is a chronic condition that requires constant blood glucose monitoring to prevent serious health risks. Accurate prediction essential for managing fluctuations and reducing the risk of hypo- hyperglycemic events. However, existing models often face limitations in horizon accuracy. This study aims develop hybrid deep learning model combining Transformer Long Short-Term Memory (LSTM) networks improve accuracy extend horizon, using personalized patient information...

Previous studies examining associations between subclinical hypothyroidism (SCH) with in vitro fertilization (IVF) outcome indicate some benefits of levothyroxine (LT4) treatment. But IVF outcomes treated SCH women whose serum Thyroid Stimulating Hormone (TSH) concentration did and not exceed 2.5 mIU/L before the cycle has been studied thoroughly. In this study, we performed a prospective cohort study 270 patients undergoing their first retrieval at single cite. receiving LT4 replacement...

Type 1 diabetes mellitus (T1DM) is well-known to trigger a disruption of lipid metabolism. This study aimed compare profile changes in T1DM patients after achieving glucose control and explore the underlying mechanisms. In addition, we seek identify novel biomarkers associated with under conditions glycemic control. A total 27 adults (age: 34.3 ± 11.2 yrs) who had maintained for over year, 24 healthy controls 35.1 + 5.56 were recruited. Clinical characteristics all participants analyzed...

Objectives Patients with type 1 diabetes (T1D) face unique challenges in glycaemic control due to the complexity and uniqueness of dietary structure China, especially terms postprandial response (PPGR). This study aimed establish a personalized model for predicting PPGR patients T1D. Materials methods Data provided by First People’s Hospital Yunnan Province, 13 T1D, were recruited an intervention at least two weeks. All asked wear continuous glucose monitoring (CGM) device under free-living...

Abstract Purpose The pathogenesis of Graves’ orbitopathy/thyroid-associated orbitopathy (TAO) is still unclear, and abnormal DNA methylation in TAO has been reported. Thus, selecting exploring biomarkers associated with may provide a reference for new therapeutic targets. Methods TAO-associated expression data were downloaded from Gene Expression Omnibus database. Firstly, weighted gene co-expression network analysis was used to obtain the TAO-related genes, which intersected differentially...

<title>Abstract</title> Type 1 diabetes (T1D) is an increasingly common chronic disease, and its incidence continues to rise globally, posing huge challenges the public health system. At same time, due need for long-term strict diet control blood sugar monitoring, management process of relatively complicated, which brings a lot inconvenience patients' daily life. Predicting glucose concentration (BGC) in T1D patients can help avoid abnormal events improve patients. However, accurate...

Cuproptosis-related long non-coding RNA (lncRNA) disease is associated with the development and progression of tumors. We aimed to investigate prediction cuproptosis-related lncRNA on prognosis immunotherapy patients thyroid carcinoma (THCA).The cancer-associated expression data lnc RNAs were downloaded from The Cancer Genome Atlas (TCGA) Ensembl database. prognostic model lncRNAs was successfully constructed through Lasso regression analysis Cox analysis. Then, value tested survival...

Objective To investigate the relationship between serum dipeptidyl peptidase 4 (DPP-Ⅳ) and body fat content distribution in type 2 diabetes (T2DM). Methods A total of 40 T2DM inpatients treated Department Endocrinology First People's Hospital Yunnan Province from July 2013 to November were enrolled. The height, weight, mass index (BMI) measured; cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol (LDL-C) detected by electrochemiluminescence assay DPP-Ⅳ enzyme linked...

Dipeptidyl peptidase-4 (DPP-4) may exert pleiotropic effects on lipid metabolism by inactivating glucagon-like peptide-1 (GLP-1),neuropeptide Y(NPY) and regulating energy balance.Nonalcoholic fatty liver disease (NAFLD) is a chronic injury without history of alcohol abuse,which characterized degeneration in parenchyma cells fat storage.Obesity,hyperlipidemia insulin resistance play important roles the development progression NAFLD.DPP-4 key modulator inhibitors,an emerging class drugs for...

The optimization of glucose control in type-1 diabetes is challenged by postprandial glycemic variability. This study aimed to compare the effects carbohydrate counting and modified fat-protein unit (FPU) algorithms following meals with different protein fat emphases adults diabetes.Thirty aged 18 45 years participated a randomized crossover trial. In random order, participants consumed four test equivalent energy macronutrient on separate mornings. FPU were used determine insulin dose for...

Abstract BackgroundPrevious evidence suggests that perfluoroalkyl and polyfluoroalkyl substances (PFASs) adversely affect ovarian function female fecundity. However, the remains insufficient to infer a direct relationship between PFAS exposure adverse assisted reproductive technology (ART) outcomes. To fill this gap, we examined follicular fluid ART outcomes in patients with poor reserve (POR) prospective study.MethodsIn total, 147 women POR were included. Eight PFASs measured (n=104)...