A5088749465- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
- RNA Research and Splicing
- Immune cells in cancer
- Sepsis Diagnosis and Treatment
- RNA modifications and cancer
- IL-33, ST2, and ILC Pathways
- Ferroptosis and cancer prognosis
- CRISPR and Genetic Engineering
- COVID-19 Clinical Research Studies
- RNA regulation and disease
- Renal cell carcinoma treatment
- Genetic and Kidney Cyst Diseases
- Helicobacter pylori-related gastroenterology studies
- Advanced Steganography and Watermarking Techniques
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Inflammatory Bowel Disease
- Immunodeficiency and Autoimmune Disorders
- Generative Adversarial Networks and Image Synthesis
- Gold and Silver Nanoparticles Synthesis and Applications
- Tuberous Sclerosis Complex Research
- Nuclear Structure and Function
- S100 Proteins and Annexins
Peking University
2020-2023
Soochow University
2023
Weatherford College
2021
Tianjin University
2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented public health crisis. Evidence suggests that SARS-CoV-2 infection causes dysregulation of the immune system. However, unique signature early responses remains elusive. We characterized transcriptome rhesus macaques and mice infected with SARS-CoV-2. Alarmin S100A8 was robustly induced in SARS-CoV-2-infected animal models as well COVID-19 patients. Paquinimod, a specific inhibitor S100A8/A9, could...
The CRISPR-Cas13 system is an RNA-guided RNA-targeting and has been widely used in transcriptome engineering with potentially important clinical applications. However, it still controversial whether Cas13 exhibits collateral activity mammalian cells.
Murine hepatitis virus strain A59 (MHV-A59) was shown to induce pyroptosis, apoptosis, and necroptosis of infected cells, especially in the murine macrophages. However, whether ferroptosis, a recently identified form lytic cell death, involved pathogenicity MHV-A59 is unknown. We utilized macrophages C57BL/6 mice intranasal infection model address this. In primary macrophages, ferroptosis inhibitor inhibited viral propagation, inflammatory cytokines released, syncytia formed after infection....
The combination of chemotherapy with photothermal therapy (PTT) has attracted extensive attention due to its excellent synergetic effect attributing the fact that hyperthermia can effectively promote tumor uptake chemotherapeutic drugs.
Summary The CRISPR-Cas13 system is an RNA-guided RNA-targeting system, and has been widely used in transcriptome engineering with potentially important clinical applications. However, it still controversial whether Cas13 exhibits collateral activity mammalian cells. Here, we found that knocking down gene expression using RfxCas13d the adult brain neurons caused death of mice, which was not resulted from loss target function or off-target effects. Mechanistically, showed exhibited cells,...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease, characterized by relapsing and remitting colon mucosal inflammation. For patients suffering from UC, higher risk of cancer has been widely recognized. Here, we found that Elf4−/− mice developed tumors with 3 cycles dextran sulfate sodium salt (DSS) treatment alone. We further showed ELF4 suppression was prevalent in both UC DSS-induced models, this caused promoter region methylation. ELF4, upon PARylation PARP1,...
Abstract The purpose of this study was to investigate the predictive value combined clinical and imaging features, compared with or radiological risk factors only. Moreover, expected results aimed improve identification severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) patients who may have critical outcomes. This retrospective included laboratory-confirmed SARS-COV-2 cases between January 18, 2020, February 16, 2020. were divided into 2 groups noncritical illness regarding...
Abstract Homozygous mutations in Ig-like domain of LMNA cause severe progeria. Unlike typical HGPS mediated by progerin due to LMNAWT/G608G mutation, it remains elusive how these homozygous We here found that patients with LMNAR527C/R527C mutation developed an atypical progeria autoimmune symptoms. Compare this led more inflammation patients. MSCs from exhibited overt and cellular senescence. Mechanistically, attenuated its binding DNA protein BAF, which aberrant aggregation Lamin A...
Abstract Monogenic autoinflammatory diseases (mAIDs) are a heterogeneous group of affecting primarily innate immunity, with various specific genetic causes. Genetic diagnosis mAIDs can assist in the patient’s management and therapy. However, large number sporadic familial cases remain genetically uncharacterized. Here, we described pediatric patient suffering from recurrent viral bacterial respiratory infection, refractory oral ulcer constipation, who was clinically diagnosed inborn errors...
Abstract Murine hepatitis virus strain A59 (MHV-A59) belongs to the β -coronavirus and is considered as a representative model for studying coronavirus infection. MHV-A59 was shown induce pyroptosis, apoptosis necroptosis of infected cells, especially murine macrophages. However, whether ferroptosis, recently identified form lytic cell death, involved in pathogenicity MHV-A59, unknown. Here, we demonstrate inhibiting ferroptosis suppresses infection upregulates expression Acsl1 , novel...