A5100449042- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Signaling Pathways in Disease
- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
- Genetic Syndromes and Imprinting
- Caching and Content Delivery
- Peer-to-Peer Network Technologies
- Advanced Neuroimaging Techniques and Applications
- Conducting polymers and applications
- Organic Electronics and Photovoltaics
- RNA Interference and Gene Delivery
- Regulation of Appetite and Obesity
- Genetic Associations and Epidemiology
- Neural dynamics and brain function
- Innovative concrete reinforcement materials
- RNA regulation and disease
- Heat Transfer and Optimization
- Cardiovascular Disease and Adiposity
- Landslides and related hazards
- Network Traffic and Congestion Control
- Structural Behavior of Reinforced Concrete
- Grouting, Rheology, and Soil Mechanics
- Structural Load-Bearing Analysis
- Schizophrenia research and treatment
Ministry of Education of the People's Republic of China
2025
Xi'an University of Architecture and Technology
2025
Tsinghua University
2009-2024
Guangdong University of Technology
2024
Huaiyin Institute of Technology
2024
First Affiliated Hospital of Xinjiang Medical University
2024
Xinjiang Medical University
2024
Kailuan General Hospital
2024
Peking University Cancer Hospital
2023
Peking University
2023
The CRISPR-Cas13 system is an RNA-guided RNA-targeting and has been widely used in transcriptome engineering with potentially important clinical applications. However, it still controversial whether Cas13 exhibits collateral activity mammalian cells.
The effects of multi-scale particle shape characteristics on the small-strain stiffness granular soils remain controversial. This study revisits this topic using well-calibrated three-dimensional discrete-element simulations incorporating a roughness–embedded contact model and particles realistic shape. Based numerical simulation results, sands magnitude Hardin's equation parameters are systematically investigated, underlying micro-mechanisms also thoroughly explored. Results indicate that...
Abstract Slot‐die coating is generally regarded as the most effective large‐scale methodology for fabrication of organic solar cells (OSCs). However, corresponding device performance significantly lags behind spin‐coated devices. Herein, active layer morphology, flexible substrate properties, and processing temperature are optimized synergistically to obtain high power conversion efficiency (PCE) both single modules. As a result, 1 cm 2 devices produce an excellent PCE 12.16% compared 12.37%...
Ultra-high-performance concrete (UHPC) is widely used in precast concrete-steel composite beams because of its beneficial properties, including reduced structural weight, higher flexural rigidity, and tensile crack formation. In comparison to conventional steel-concrete beams, steel-UHPC exhibit superior characteristics, deadweight, enhanced stiffness, the capacity withstand cracking. One successful attempt at meeting current demands for expedited girder engineering development with...
Increased cerebellar-default mode network (DMN) connectivity has been observed in first-episode, drug-naive patients with schizophrenia. However, it remains unclear whether increased cerebellar-DMN starts earlier than disease onset. Thirty-four ultra-high risk (UHR) subjects, 31 schizophrenia and 37 healthy controls were enrolled for a resting-state scan. The imaging data analyzed using the seed-based functional (FC) method. Compared controls, UHR subjects shared between right Crus I...
Enhanced heat and mass transfer in a falling film liquid desiccant dehumidifier is crucial for improving the efficiency of air conditioning systems. However, no study has yet been undertaken to examine impact range different enhancing elements on dehumidification performance. This comprehensively investigates compares hydrodynamics performance plates with various based inlet velocity humidity, solution velocity, concentration, as well element spacing height. The results demonstrate that,...
Abstract Subjects with psychosis risk syndrome (PRS) have structural and functional abnormalities in several brain regions. However, regional synchronization of PRS has not been clarified. We recruited 34 subjects 37 healthy controls. Regional homogeneity (ReHo) resting-state magnetic resonance scans was employed to analyze these participants. Receiver operating characteristic curves support vector machines were used detect whether abnormal could be utilized separate from observed that...
Steel-ultra-high-performance concrete (UHPC) composite beams employing single embedded nut bolted shear connectors (SENBs) in full-depth precast deck systems represent a competition attempt recent years, which can fully utilize the exceptional material characteristics of both SENBs and UHPC. Due to demountable SENBs, this innovative beam could be easily deconstructed repair or recycle deteriorated components. However, generally combine tensile loads during service stages. Nevertheless,...
As described by Zhixiang Wei and co-workers in article number 1805089, for large-area organic solar cells, high active-layer thickness tolerability is generally required, the methods to reduce power conversion efficiency losses are critical, printing suitable roll-to-roll highly important. By combining material requirements, modular designs, methods, application of cells will be successfully realized near future.
Summary The CRISPR-Cas13 system is an RNA-guided RNA-targeting system, and has been widely used in transcriptome engineering with potentially important clinical applications. However, it still controversial whether Cas13 exhibits collateral activity mammalian cells. Here, we found that knocking down gene expression using RfxCas13d the adult brain neurons caused death of mice, which was not resulted from loss target function or off-target effects. Mechanistically, showed exhibited cells,...
Classical forward and reverse mouse genetics require germline mutations and, thus, are unwieldy to study sleep functions of essential genes or redundant pathways. It is also time-consuming conduct EEG/EMG-based screening because labor-intensive surgeries genetic crosses. Here, we describe a highly accurate SleepV (video) system adeno-associated virus (AAV)-based adult brain chimeric (ABC)-expression/KO platform for somatic analysis in male female mice. A pilot ABC screen identifies CREB...
It has been suggested that the imprinted gene, H19, plays a crucial role in development of cancer. In present study, we attempted to treat abnormal expression and methylation status H19 A549 cells using valproic acid (VPA), ascorbic (Vc), 5-aza-Cytidine (5-Aza). The results VPA administration could alter pattern while hypomethylation DMR was unchanged. Furthermore, overexpression HDAC1 DNMT1 associated with decreased VPA-treated cells. Western blot showed p53 protein increased following...
In order to study the effects of soda residue content, particle size, moisture and curing age on unconfined compressive strength (UCS) cement lime soil (SRCLS), a 4-factor, 4-level orthogonal experimental design was employed in this study. Different conditions SRCLS UCS their impacts were tested analyzed. The internal microstructure hydration products studied using SEM XRD explore strengthening mechanism SR SRCLS. results indicate that as content gradually increased, initially increased then...
Endogenous Netrin-1 (NT-1) protein was significantly increased after cerebral ischemia, which may participate in the repair transient ischemic injury. In this work, we explore whether NT-1 can be steadily overexpressed by AAV and exogenous promote neural stem cells migration from subventricular zone (SVZ) region ischemia. Adult CD-1 mice were injected stereotacticly with adeno-associated virus carrying gene (AAV-NT-1). Mice underwent 60 minutes of middle artery occlusion one week injection....
The majority of renal cell carcinomas (RCCs) are characterized by loss function the tumor suppressor gene von Hippel Lindau (VHL), which acts as ubiquitin ligase for hypoxia-inducible factor-1α (HIF-1α). In absence VHL, HIF-1α protein becomes stabilized and contributes to tumorigenesis. Recent data demonstrate antitumor efficacy VHL promoter in RCC cells. This study demonstrates that N-Myc downstream-regulated 2 (NDRG2) is a potential regulator VHL. NDRG2 involved proliferation invasion...