A5101493785- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Glaucoma and retinal disorders
- Colorectal Cancer Treatments and Studies
- Histone Deacetylase Inhibitors Research
- Enhanced Recovery After Surgery
- Child Abuse and Related Trauma
- Lipid metabolism and disorders
- Cancer Cells and Metastasis
- Inflammatory Bowel Disease
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Connective tissue disorders research
- Pharmaceutical studies and practices
- Nasal Surgery and Airway Studies
- Diet and metabolism studies
- Quinazolinone synthesis and applications
- Viral-associated cancers and disorders
- Retinal Imaging and Analysis
- Photodynamic Therapy Research Studies
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Cancer, Stress, Anesthesia, and Immune Response
- Nuclear Receptors and Signaling
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Xiyuan Hospital
2024
Yue Bei People's Hospital
2019-2024
Shantou University
2019-2024
City Of Hope National Medical Center
2021-2023
Harbin Medical University
2021
Second Affiliated Hospital of Harbin Medical University
2021
City of Hope
2021
Fourth Affiliated Hospital of China Medical University
2020
China Medical University
2020
Epigenetic silencing mechanisms play an important role in chemoresistance of human cancer. Here we report the upregulated expression metastasis‐associated protein 1 (MTA1), a component nucleosome remodeling deacetylation (NuRD) complex, chemoresistant prostate cancer (PCa). MTA1 knockdown PC‐3 cells inhibited cell proliferation and enhanced docetaxel (DTX)‐induced death. Conversely, overexpression promotes DTX cells. acted as potent corepressor nuclear receptor NR4A1 transcription by...
The aim of the present study was to investigate correlation between expression levels excision repair cross complementing 1 (ERCC1), thymidylate synthase (TYMS), class III β-tubulin (TUBB3), ribonucleoside-diphosphate reductase (RRM1) and topoisomerase IIα (TOP2A) with clinical characteristics patients esophageal squamous cell carcinoma (ESCC). A total 29 ESCC tissue samples were collected from that had not previously received systematic treatment. ERCC1, TYMS, TUBB3, RRM1 TOP2A determined...
Abstract Chronic myeloid leukaemia (CML) is a haematological malignancy characterized by the constitutive tyrosine kinase activity of BCR‐ABL1 fusion protein. Flumatinib, second‐generation inhibitor, has exhibited superior clinical efficacy compared to its precursor, imatinib. However, with increased use, resistance flumatinib emerged as significant challenge. To investigate mechanisms in CML, we induced human CML cell line K562 using concentration gradient method vitro, successfully...
The present study analyzed the expression of histone deacetylase (HDAC) 1, 2 and 3 in primary esophageal squamous cell carcinoma (ESCC) samples how their levels correlate with clinicopathological parameters. ESCC patients (n=88) had received no previous treatment before undergoing surgical excision. mRNA HDAC1, -2 -3 were detected by semi-quantified PCR distal normal samples. relationship parameters was χ2 test. correlation among these HDACs Pearson's Compared tissues, higher but not HDAC2...
This study was conducted retrospectively to investigate the survival of patients undergoing gastric cancer surgery with epidural combined general anesthesia (EGA) and alone (GA).
Immune checkpoint inhibitors (ICIs) have shown promise in treating a variety of cancers. Their increased use coincides with incidence immunotherapy-mediated colitis (IMC), common adverse effect. Optimal strategy for endoscopic evaluation IMC (full colonoscopy or flexible sigmoidoscopy) is not well-defined.Retrospective review all patients at City Hope referred to gastroenterology due gastrointestinal symptoms was performed. Patients an existing histologic diagnosis established outside...
The hepatocellular carcinoma (HCC) patients with bile duct tumor thrombus (BDTT) usually have no specific clinical symptoms at early stages. HCC BDTT was misdiagnosed when the intrahepatic small, even undetectable. In this study, 5 cases of as choledocholithiasis and cholangitis in local hospital are described. We analyzed retrospectively summarized our experiences these during past years. diagnosis, treatment, outcome discussed. Three underwent hepatectomy thrombectomy T-tube drainage. One...
To study the mutations in exons 3, 6, 7, 11 and 12 of phenylalanine hydroxylase gene (PAH) Shanxi population.The flanking sequences PAH were detected by PCR-DNA sequencing, 59 patients with phynelketonuria(PKU) 100 healthy children from province.By sequence analysis, three single nucleotide polymorphism (SNP) Q232Q (CAA>CAG), V245V (GTG>GTA) L385L (CTG>CTC) both children, frequencies nt 696, 735 1155 cDNA up to 96.2%, 76.1% 7.6% respectively, 97.0%, 77.3% 8.3% respectively controls. In...
ABSTRACT Efforts have been made to find effective medical drugs for cervical cancer treatment. The incidence of ranks second among women, and is a serious threat women's health. Aberrant activation the nonreceptor protein tyrosine kinases such as Src commonly observed in progressive stages human tumors. Thus, targeting kinase could be promising strategy therapy. In this study, we explored potential utility bosutinib treatment cancer. We found that bosutinib, potent dual Src/Abl inhibitor,...
Objective To examine the expression of integrin-linked kinase (ILK) in gastric cancer (GC) cell lines and normal epithelial cells from human, investigate effect ILK inhibitor Cpd22 on proliferation invasion GC cells. Methods The GES1 was analyzed by Western blotting; The AGS MKN1 were treated with an small molecule inhibitor, Cpd22, to downregulate function; Cell determined methyl thiazol tetrazolium (MTT) assay, monolayer colony formation assay Transwell assay. alteration...
Introduction: Immune checkpoint inhibitors (ICIs) have shown promise in treating a variety of cancers. Their increased use has coincided with higher prevalence immunotherapy-mediated colitis (IMC), common adverse effect. Optimal strategy for endoscopic evaluation IMC (full colonoscopy or flexible sigmoidoscopy) is not well-defined. In this cross-sectional, single-center study, we evaluate the clinical, endoscopic, and histopathological features patients undergoing assess diagnostic yield...
Abstract Background: Ribophorin family (RPNs) are important regulatory subunits of the proteasome. By influencing Ubiquitin-proteasome system activity, RPNs responsible for almost all processes physiology and pathology mammalian cells. Nevertheless, little is known about role in HCC. Methods: In this work, using online databases Oncomine, UCSC, Kaplan-Meier Plotter, UALCAN, cBioPortal, TIMER2, GeneMANIA,and STRING, we first evaluated expression, diagnostic, prognostic, genetic alteration,...