A5101718965- Sperm and Testicular Function
- Circular RNAs in diseases
- Reproductive Biology and Fertility
- Cancer Mechanisms and Therapy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Renal and related cancers
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Testicular diseases and treatments
- Ginseng Biological Effects and Applications
- Radiopharmaceutical Chemistry and Applications
- Neonatal Respiratory Health Research
- Monoclonal and Polyclonal Antibodies Research
- Respiratory Support and Mechanisms
- RNA Research and Splicing
- Immune Response and Inflammation
- CRISPR and Genetic Engineering
- Andrographolide Research and Applications
- Platelet Disorders and Treatments
- Infant Nutrition and Health
- Advanced Photonic Communication Systems
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Photonic and Optical Devices
- Vibration Control and Rheological Fluids
Binzhou University
2025
Binzhou Medical University
2025
Simcere Pharmaceutical (China)
2024
Nanjing University
2023
Yunnan Center for Disease Control And Prevention
2023
First People's Hospital of Yunnan Province
2023
Zhejiang University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Air Force Medical University
2008-2021
Weatherford College
2020
Most eukaryotic cells contain nearly equimolar amounts of nucleosomes and H1 linker histones. Despite their abundance the potential functional specialization subtypes in multicellular organisms, gene inactivation studies have failed to reveal essential functions for histones vivo. Moreover, vitro suggest that may not be absolutely required assembly chromosomes or nuclei. By sequentially inactivating genes three mouse (H1c, H1d, H1e), we showed are mammalian development. Embryos lacking die...
Background/Aims: The current study aimed to investigate the role by which fibronectin 1 (FN1) influences cell cycle, senescence and apoptosis in human glioma cells through PI3K/ AKT signaling pathway. Methods: Differentially expressed genes (DEGs) were identified based on gene expression data (GSE12657, GSE15824 GSE45921 datasets) probe annotation files from Gene Expression Omnibus. DEGs connection with ontology (GO) enrichment analysis Kyoto Encyclopedia of Genes Genomes (KEGG) pathway...
Lactoferrin (LF) is a beneficial multifunctional protein in milk. The objective of this study was to determine whether bovine transgenic milk containing recombinant human lactoferrin (rhLF) can modulate intestinal flora the neonatal pig as an animal model for infant. We fed 7-day-old piglets (i) ordinary whole (OM), (ii) 1:1 mixture OM and rhLF (MM), or (iii) (LFM). LFM provided better average daily mass gain than (P = 0.007). PCR-denaturing gradient gel electrophoresis 16S rDNA sequencing...
Deregulated thermal factors have been frequently implicated in the pathogenesis of male infertility, but molecular basis through which certain responses are directed remain largely unknown. We previously reported that overexpression exogenous Metastasis-associated protein 1 (MTA1) protects spermatogenic tumor cells GC-2spd (ts) against heat-induced apoptosis. To further dissect underlying mechanism, we addressed here fine coordination between MTA1 and p53 pachytene spermatocytes upon...
Epigenetic silencing mechanisms play an important role in chemoresistance of human cancer. Here we report the upregulated expression metastasis‐associated protein 1 (MTA1), a component nucleosome remodeling deacetylation (NuRD) complex, chemoresistant prostate cancer (PCa). MTA1 knockdown PC‐3 cells inhibited cell proliferation and enhanced docetaxel (DTX)‐induced death. Conversely, overexpression promotes DTX cells. acted as potent corepressor nuclear receptor NR4A1 transcription by...
Proper control of apoptotic signaling is important for maintenance testicular homeostasis after ionizing radiation (IR). Herein, we challenged the hypothesis that ghrelin, a pleiotropic modulator, potentially involved in IR-induced germ cell injury. Lower body exposure to 2 Gy IR induced notable increase ghrelin expression nuclear differentiating spermatogonia at defined stages, with an impairment Leydig cells (LCs)-expressing ghrelin. Unexpectedly, inhibition pathway by intraperitoneal...
Understanding how castration-resistant prostate cancer (CRPC) cells survive the androgen-deprivation condition is crucial for treatment of this advanced (PCa). Here, we reported first time up-regulation protein S (PROS), an anticoagulant plasma glycoprotein with multiple biological functions, in androgen-insensitive PCa and experimentally induced cells. Overexpression exogenous PROS LNCaP reduced androgen deprivation-induced apoptosis enhanced anchorage-dependent clonogenic ability under...
Abstract Disruption of the nursery function in Sertoli cells (SCs) by reducing lactate production, a preferred energy substrate for developed germ (spermatocytes and spermatids), is tightly associated with spermatogenic failure such as SC-only syndrome (SCOS). However, whether this complicated pathogenesis regulated certain miRNAs at post-transcriptional level remain fascinating but largely unknown. Here we show first time that mmu-miR-320-3p was exclusively expressed murine SCs expression...
Deregulated expression of protein tyrosine phosphorylation has been implicated in testicular response to different stimuli. Herein, YES1, a nonreceptor kinase, was found be significantly up-regulated pachytene spermatocytes (PS) during early recovery from transient heat stress. Coculture PS with Sertoli cells (SCs) could enhance the hyperthermia-induced YES1 activation, indicative positive regulation paracrine signaling. Moreover, SU6656, selective inhibitor, shown effectively block...
Two-dimensional (2-D) optical phased arrays (OPAs) usually suffer from limited scan ranges and small aperture sizes. To overcome these bottlenecks, we utilize an aperiodic 32 × grid to increase the beam scanning range furthermore distribute 128 grating antennas sparsely among 1024 points so as reduce array element number. The genetic algorithm is used optimize uneven spacings sparse distribution of antennas. With measures, a 128-channel 2-D OPA operating at 1550 nm realizes grating-lobe-free...
Casein kinase I alpha (CK1α) is a member of serine/threonine protein kinase, generally present in all eukaryotes. In mammals, CK1α regulates the transition from interphase to metaphase mitosis. However, little known about its role meiosis. Here we examined Ck1α mRNA and expression, as well subcellular localization mouse oocytes germinal vesicle late 1-cell stage. Our results showed that expression level was increased metaphase. Immunostaining colocalized with condensed chromosomes during...
<b><i>Background/Aims:</i></b> The objective of this study is to evaluate the hypouricemic and nephroprotective effects an active fraction from <i>Polyrhachis vicina Roger</i> (AFPR) in potassium oxonate-induced hyperuricemic rats. <b><i>Methods:</i></b> Hyperuricemia was induced by oxonate male AFPR orally administered rats for 12 consecutive weeks. Serum, liver kidney samples were collected mechanism analysis. levels serum uric...
Abstract Acute lung injury (ALI) is a highly lethal pulmonary disease that causes edema, hypoxemia and respiratory failure. Recent evidence indicates nuclear factor-kappa B (NF-κB) plays crucial role in ALI development. However, the regulatory mechanism of NF-κB on remains enigmatic. In this study, we investigated potential molecular induced by lipopolysaccharide (LPS). BALB/c mice were subjected to intratracheal spraying LPS generate an mode, with activity tissues being detected enzyme...
Acute lung injury (ALI), is a rapidly progressing heterogenous pulmonary disorder that possesses high risk of mortality. Accumulating evidence has implicated the activation p65 subunit NF-κB [NF-κB(p65)] in pathological process ALI. microRNAs (miRNAs), group small RNA molecules, have emerged as major governors due to their post-transcriptional regulation gene expression wide array processes, including The dysregulation miRNAs and been human diseases. In current study, we set out decipher...
As somatic cells in the testis seminiferous tubule, Sertoli provide medium for spermatogenesis. One of important functions is synthesizing and secreting cell factors to affect production sperm; however, much those molecular regulation mechanisms remain unknown. Here, we confirm localization protein SPATA2 (spermatogenesis-associated 2), which had previously been shown be highly expressed adult mouse testis. To further conduct a functional study, generated global knockout mice via use...
Abstract We assessed the predictive value of serum ammonia level on admission for 28-day mortality patients with sepsis. retrospectively included septic admitted to emergency department West China Hospital, Sichuan University and The Fourth People's Hospital Zigong city from June 2017 May 2018. Patients were divided into 2 groups according survival. Comparisons sequential organ failure assessment (SOFA) score made between groups. Multivariate logistic regression models employed determine...