A5004185708- Retinoids in leukemia and cellular processes
- Ubiquitin and proteasome pathways
- Arsenic contamination and mitigation
- DNA Repair Mechanisms
- RNA modifications and cancer
- Hemoglobin structure and function
- Genomics, phytochemicals, and oxidative stress
- Ferroptosis and cancer prognosis
- Chemical synthesis and alkaloids
- High Altitude and Hypoxia
- Bioactive Natural Diterpenoids Research
- Glutathione Transferases and Polymorphisms
- Epigenetics and DNA Methylation
- Physiological and biochemical adaptations
- Histone Deacetylase Inhibitors Research
- Protease and Inhibitor Mechanisms
- Traditional Chinese Medicine Analysis
- Plant-based Medicinal Research
- Natural product bioactivities and synthesis
- Graphene and Nanomaterials Applications
- HIV/AIDS drug development and treatment
- Phytochemistry and Biological Activities
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
Binzhou University
2025
Binzhou Medical University
2025
University of British Columbia
2024-2025
University of California, Riverside
2015-2022
Shanghai Normal University
2022
Guiyang Medical University
2020
University of Helsinki
2011-2012
Abstract Background Our lab established an in vitro damage model using human colonoids grown as 2D Intestinal Epithelial Cells (IECs) monolayers Air-Liquid Interface (ALI) culture. Upon repeated injury by submergence, these colonoid lost their epithelial barrier integrity and regrowth potential. Changes mRNA expression global proteomic profiling of this were found to be very similar those Inflammatory Bowel Disease (IBD) pre-colon cancer like state. Aims Preliminary proteomics studies on is...
Arsenic toxicity is a serious public health problem worldwide that brings more than 100 million people into the risk of arsenic exposure from groundwater and food contamination. Although there accumulating evidence linking with aberrant cytosine methylation in global genome or at specific genomic loci, very few have investigated impact on oxidation 5-methylcytosine (5-mC) mediated by Ten-eleven translocation (Tet) family proteins. Owing to high binding affinity As(III) toward cysteine...
Aims: Colorectal cancer (CRC) has high mortality and morbidity rates; however, the mechanism of CRC cells uncontrolled proliferation is unclarified, E3 ligases are widely reported to have crucial functions in cancers.HERC3 was once recognized as an important role CRC, however its effects on cell cycle blank.Methods: Correlation between HERC3 clinical characteristics analyzed.Coimmunoprecipitation, mass spectrometry analysis GST-pull down were performed identify interacting-proteins...
Activation of the nuclear factor erythroid 2–related 2 (Nrf2) antioxidant response signaling pathway is a major mechanism for cellular defense against oxidative stress. Arsenite, widespread contaminant in drinking water, known to induce stress and activate Nrf2-dependent through stabilization Nrf2 protein by inhibiting its ubiquitination via Cul3–Rbx1–Keap1 (cullin 3, RING-box 1, Kelch-like ECH-associated 1) E3 ubiquitin ligase, degradation 26S proteasome, though underlying mechanism,...
Human exposure to arsenic in drinking water is known be associated with the development of bladder, lung, kidney, and skin cancers. The molecular mechanisms underlying carcinogenic effects species remain incompletely understood. DNA interstrand cross-links (ICLs) are among most cytotoxic type lesions that block replication transcription, these can induced by endogenous metabolism exogenous agents. Fanconi anemia (FA) a congenital disorder manifested elevated sensitivity toward cross-linking...
Arsenic is a ubiquitous environmental contaminant with widespread public health concern. Epidemiological studies have revealed that chronic human exposure to arsenic in drinking water associated the prevalence of skin, lung, and bladder cancers. Aberrant histone modifications (e.g., methylation, acetylation, ubiquitination) were previously found be accompanied by exposure; thus, perturbation epigenetic pathways thought contribute carcinogenesis. Arsenite known interact zinc finger motifs...
Further study on the constituents of Salvia miltiorrhiza BUNGE (Labiatae) afforded a novel seco-abietanoid named tanshinlactone. The structure tanshinlactone was characterized basis spectral data. biogeneses and related compound are discussed.
Arsenic pollution in drinking water is a widespread public health problem, and it affects approximately 200 million people over 70 countries. Many human diseases, including neurodegenerative disorders, are engendered by the malfunction of proteins involved important biological processes elicited protein misfolding and/or loss quality control during translation. exposure results proteotoxic stress, though detailed molecular mechanisms remain poorly understood. Here, we showed that arsenite...
Arsenic is known to cause damage the body's immune system by inducing epigenetic changes. However, molecular mechanism of this remains elusive. Here, we report that arsenic disrupts morphology lymphocytes, decreases cell viability, and results in abnormal proportions T lymphocyte subsets. Moreover, our revealed can reduce global acetylation histone H4 at K16 (H4K16 ac) lymphocytes via decreasing level males absent on first but upregulates mRNA protein levels forkhead/winged-helix box P3...
Arsenic contamination in food and groundwater constitutes a public health concern for more than 200 million people worldwide. Individuals chronically exposed to arsenic through drinking ingestion exhibit higher risk of developing cancers cardiovascular diseases. Nevertheless, the underlying mechanisms toxicity are not fully understood. Arsenite is known bind deactivate RING finger E3 ubiquitin ligases; thus, we reason that systematic interrogation about how arsenite exposure modulates global...