The importance of mRNA methylation erased by ALKBH5 in biogenesis, decay, and translation control is an emerging research focus. Ectopically activated YAP associated with the development many human cancers. However, mechanism whereby regulates expression activity to inhibit NSCLC tumor growth metastasis not clear.Protein transcript interactions were analyzed normal lung cell cells. Gene was evaluated qPCR reporter assays. Protein levels determined immunochemical approaches. Nucleic acid...

Abstract The roles of aberrantly regulated autophagy in human malignancy and the mechanisms that initiate sustain repression carcinogenesis are less well defined. Activation oncogene UBE2C concurrently underlying initiation, progression, metastasis lung cancer exploration essential association with will confer more options searching novel molecular therapeutic targets cancer. Here we report aberrant activation tumors from patients associates adverse prognosis enhances cell proliferation,...

Eight novel and three known antioxidant peptides isolated from protein hydrolysate of Moringa oleifera seeds, using ultrafiltration, anion-exchange chromatography, gel filtration chromatography reversed phase high performance liquid (RP-HPLC). The were identified as Gly-Tyr (GY), Pro-Phe-Glu (PFE), Tyr-Thr-Arg (YTR), Phe-Gly (FG), Gln-Tyr (QY), Ile-Asn (IN), Ser-Phe (SF), Ser-Pro (SP), the Tyr-Phe-Glu (YFE), Ile-Tyr (IY) Leu-Tyr (LY), respectively, amino acid sequence analyzer electrospray...

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). retracted at the request of Authors. After publication our EBioMedicine [[1]Guo J. et al.The miR 495-UBE2C-ABCG2/ERCC1 axis reverses cisplatin resistance by downregulating drug genes in cisplatin-resistant non-small cell lung cancer cells.EBioMedicine. 2018; 35: 204-221Summary Full Text PDF PubMed Scopus (0) Google Scholar], several...

Recent evidence indicates that metformin inhibits mammalian cancer growth and metastasis through the regulation of microRNAs. Metformin regulates miR-381 stability, which plays a vital role in tumor progression. Moreover, increased YAP expression activity induce non-small cell lung (NSCLC) metastasis. However, molecular mechanism underpinning how metformin-induced upregulation directly targets or its interactions with epithelial-mesenchymal transition (EMT) marker protein Snail NSCLC is...

Saline-tolerant medicinal plants possess novel chemical constituents with high bioactivity because of their unique secondary metabolic pathways.

Our previous researches have showed that the Leptopus genus plants possess significant anti‐tumor and hepatoprotective effects, over 50 triterpenoids were isolated from these plants. In present work, anti‐inflammatory activities of extracts four evaluated before phytochemical experiments. Subsequently, eight flavonoids (1‐8) including two previously undescribed prenylated (1‐2) whole clarkei. The structures new compounds unequivocally elucidated by HRESIMS 1D/2D NMR data. Additionally, all...

// Jiwei Guo 1, * , Yan Wu Lijuan Yang 1 Jing Du Kaikai Gong Weiwei Chen Juanjuan Dai XueLin Li Sichuan Xi Cancer Research Institute, Binzhou Medical University Hospital, 256603, P.R. China These authors contributed equally to this work Correspondence to: Xi, email: xh_xi@yahoo.com Keywords: lung cancer, YAP, NCTD, EMT, cell cycle arrest Received: August 17, 2016 Accepted: November 21, Published: 26, ABSTRACT The efficacy of available cancer therapeutic interference is significantly limited...

A chemical investigation was conducted on the aerial parts of mangrove plant Sonneratia paracaseolaris, yielding five new triterpenoid paracaseolins A–E (1–4, and 11) together with twelve known analogues (5–10, 12–17). Their structures were established by extensive spectroscopic methods comparisons their data those related compounds. The cytotoxicities against P388, HeLa, A549, K562 tumor cell lines anti-H1N1 (Influenza virus) activities for isolates evaluated. Compound 4 showed potent...

Marine sponges continue to serve as a rich source of alkaloids possessing interesting biological activities and often exhibiting unique structural frameworks. In the current study, chemical investigation on marine sponge Pericharax heteroraphis collected from South China Sea yielded one new imidazole alkaloid named naamidine J (1) along with four known ones (2–5). Their structures were established by extensive spectroscopic methods comparison their data those related compounds. All isolates...

Chemical investigation on the soft coral Sarcophyton sp. collected from South China Sea yielded three new polyhydroxylated steroids, compounds (1–3), together with seven known ones (4–10). Their structures were established by extensive spectroscopic methods and comparison of their data those related compounds. All isolates possessed 3β,5α,6β-trihydroxylated steroidal nucleus. The cytotoxicities against selected HL-60, HeLa K562 tumor cell lines anti-H1N1 (Influenza A virus (IAV)) activities...

Context Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) are promising therapeutic targets for AD.Objective To evaluate the inhibitory effects aaptamine on two cholinesterases investigate in vivo effect AD zebrafish model.Materials methods Aaptamine was isolated from sponge Aaptos suberitoides Brøndsted (Suberitidae). Enzyme inhibition, kinetic analysis, surface plasmon resonance...

Genome mining revealed that the genomes of basidiomycetes may include a considerable number biosynthetic gene clusters (BGCs), yet numerous remain unidentified. Herein, we report combination genome with an OSMAC (one strain, many compounds) approach to characterize spectrum melleolides produced by Armillaria tabescens CPCC 401429. Using F1 fermentation medium, metabolic pathway cluster mel was successfully upregulated. From extracts wild-type two new (1 and 2), along five orsellinic...

The Yellow River Delta possesses lots of characteristic medicinal plants due to its high salinity and alkaline environment Limonium sinense is an iconic plant. However, there are very few studies on L. chemical constituents have not been investigated in recent ten years. In the present study, bioactivities were fully studied for first time. UPLC-MS/MS method combined with database comparison identified 109 compounds mainly including flavonoids, alkaloids polyphenols. addition, potential...

Deregulated Sonic Hedgehog (SHH) pathway facilitates the initiation, progression, and metastasis of Non-small cell lung cancer (NSCLC), confers drug resistance renders a therapeutic interference option to patients with poor prognosis. In this study, we screened evaluated specificity Chinese herb Scutellariabarbata D. Don extraction (SBE) in repressing SHH signaling block NSCLC progression. Our study confirmed that aberrant activation signal conferred more proliferative invasive phenotypes...

Long noncoding RNAs (lncRNAs) play a critical role in the development of lung carcinoma. The mechanism MALAT1 carcinoma is not understood very well. This study aimed to investigate progression and underlying miR-491-5p mediated regulation UBE2C expression. results indicated that expression was often augmented cells. Suppression blocked proliferation, invasion migration ability cancer cells inhibited UBE2C. restoration attenuated knockdown-induced anti-cancer effects. Moreover, were as...

Context Aaptamine is a potent ocean-derived non-traditional drug candidate against human cancers. However, the underlying molecular mechanisms governing aaptamine-mediated repression of lung cancer cells remain largely undefined.Objective To examine inhibitory effect aaptamine on proliferation and progression non-small cell carcinoma (NSCLC) dissect potential involved in its anticancer functions.Materials methods In vitro assays proliferation, cycle analysis, clonal formation, apoptosis...