A5101424753- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Extracellular vesicles in disease
- Bone and Joint Diseases
- Autophagy in Disease and Therapy
- Neuroendocrine Tumor Research Advances
- Medicinal Plants and Neuroprotection
- Mesenchymal stem cell research
- Neuroscience and Neuropharmacology Research
- Synthesis and Biological Evaluation
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Folate and B Vitamins Research
- Microplastics and Plastic Pollution
- RNA Research and Splicing
- Toxoplasma gondii Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Family Business Performance and Succession
- Insect Pest Control Strategies
- Cardiac Fibrosis and Remodeling
- Infectious Disease Case Reports and Treatments
- Apelin-related biomedical research
- Hedgehog Signaling Pathway Studies
Chinese PLA General Hospital
2025
Texas Tech University
2017-2024
Liaoning University of Traditional Chinese Medicine
2017-2024
Zhejiang University
2011-2023
Institute of Biophysics
2023
Xiangyang Hospital of Traditional Chinese Medicine
2021
Binzhou Medical University
2008-2020
Binzhou University
2016-2020
Xian Yang Central Hospital
2020
Hubei University of Chinese Medicine
2017-2019
Nanoplastics have been recently found widely distributed in our natural environment where ubiquitously bacteria are major participants various material cycles. Understanding how nanoplastics interact with bacterial cell membrane is critical to grasp their uptake processes as well analyze associated risks ecosystems and human microflora. However, little known about the detailed interaction of differentially charged bacteria. The present work experimentally theoretically demonstrated that...
Mesenchymal stem cells (MSCs) with multipotential differentiation capacity can differentiate into bone under specific conditions and be used to treat osteonecrosis (ON) of the femoral head (ONFH) through cell transplantation. The current study aims explore role marrow (BM) MSCs (BMSCs)-derived exosomes carrying microRNA-122-5p (miR-122-5p) in ONFH rabbit models.First, models were established. ONFH-related miRNAs screened using Gene Expression Omnibus (GEO) database. A gain-of-function was...
Abstract Nanoplastics are emerging pollutants of global concern. Agricultural soil is becoming a primary sink for nanoplastics generated from plastic debris. The uptake and accumulation by crops contaminate the food chain pose unexpected risks to human health. However, whether can enter grains their impact on crop grown in contaminated still unknown. Here, translocation polystyrene (PS‐NPs) crops, including peanut ( Arachis hypogaea L.) rice Oryza sativa investigated. It demonstrated PS‐NPs...
Cisplatin is one of the most active cytotoxic agents for non-small cell lung cancer (NSCLC) treatment. However, development cisplatin resistance common. Bu-Zhong-Yi-Qi decoction (BZYQD), a Chinese traditional herbal medicine, widely used enhancement antitumor effect in other medications. In this study, we evaluated and drug-resistance reversal mechanism BZYQD combined with on cisplatin-resistant A549/DDP cells. Our results showed that exhibited direct chemosensitizing effects. Cotreatment...
Protocell fitness under extreme prebiotic conditions is critical in understanding the origin of life. However, little known about protocell's survival and radiations. Here we present a radioresistant protocell model based on assembly two types coacervate droplets, which are formed through interactions inorganic polyphosphate (polyP) with divalent metal cation cationic tripeptide, respectively. Among only polyP-Mn droplet radiotolerant provides strong protection for recruited proteins. The...
Traumatic osteonecrosis of the femoral head (ONFH) is a condition leading to collapse head, and primary treatment total hip replacement, which has poor prognosis. The current study was conducted with aim investigating role exosomes from bone marrow-derived mesenchymal stem cells (BM-MSCs) carrying microRNA-224-3p (miR-224-3p) in traumatic ONFH. Initially, microarray analysis performed screen differentially expressed genes miRs associated Patients nontraumatic ONFH were enrolled, HUVECs...
Human leishmaniasis is an infectious disease caused by Leishmania protozoan parasites. Current chemotherapeutic options against the deadly have significant limitations. The ergosterol biosynthetic pathway has been identified as a drug target in Leishmania. However, remarkable differences efficacy of antifungal azoles that inhibit biosynthesis reported for treatment leishmaniasis. To better understand sterol and elucidate mechanism underlying differential azoles, we developed new LC-MS/MS...
Cisplatin resistance is one of the major obstacles in non-small cell lung cancer (NSCLC) treatment. Intriguingly, elevated lactate levels were observed cisplatin-resistant cells, which spurred further investigation into their underlying biological mechanisms.
The osteogenic differentiation ability of bone marrow mesenchymal stem cells (BMSCs) is an important aspect studying osteoporosis (OP). This study aims to explore the role SYVN1 in regulating BMSCs and suggest its potential as a treatment for OP. were differentiated using induction. expression at different induction time points was analyzed by Western blot (WB). levels markers, including RUNX2, ALP, OCN, measured RT-qPCR. EdU staining colony formation assays performed evaluate impact on...
Breeding to increase folate levels in edible parts of plants, termed biofortification, is an economical approach fight against deficiency humans, especially the developing world. Germplasm with elevated folates are a useful genetic source for both breeding and direct use. Spinach one well-know vegetables that contains relatively high amount folate. Currently, little known about how much folate, their composition varies different spinach accessions. The aim this study was investigate natural...
The Mn-phosphate complex (Mn-Pi) plays a key role in the cellular resistance of radioresistant bacteria. evolutionarily ancient polyphosphate polymers (polyphosphate [PolyP]) could effectively chelate Mn 2+ and donate phosphates.
Glutamate is an excitatory neurotransmitter involved in neural function. Excess accumulation of intercellular glutamate leads to increasing concentration reactive oxygen species (ROS) and nitrogen (RNS) neuronal cells. In this study, we investigated the antioxidant activity several typical superior compounds among four cells, determined scavenging free radicals. The vivo assay was also carried out compare protective effect glutamate-induced cell damage. Hierarchical clustering analysis used...
Deregulated Sonic Hedgehog (SHH) pathway facilitates the initiation, progression, and metastasis of Non-small cell lung cancer (NSCLC), confers drug resistance renders a therapeutic interference option to patients with poor prognosis. In this study, we screened evaluated specificity Chinese herb Scutellariabarbata D. Don extraction (SBE) in repressing SHH signaling block NSCLC progression. Our study confirmed that aberrant activation signal conferred more proliferative invasive phenotypes...
Visceral leishmaniasis is a life-threatening parasitic disease, but current antileishmanial drugs have severe drawbacks. Antifungal azoles inhibit the activity of cytochrome P450 (CYP) 51 enzymes which are responsible for removing C14α-methyl group lanosterol, key step in ergosterol biosynthesis Leishmania. However, they exhibit varying degrees activities culture, suggesting existence unrecognized molecular targets. Our previous study reveals that, Leishmania, lanosterol undergoes parallel...
Abstract: Folate deficiency increases the risk of chronic diseases, including neural tube defects (NTDs) in infants, megaloblastic anemia, cardiovascular disease, and some cancers adults. China is most NTDs prevalent area world. can be reduced by proper supply fresh leafy green vegetables but little known about folate content vitamers commonly consumed Chinese population. The purposes this study were first to analyze important that contribute intake population second estimate significance...
The aim of the present study was to investigate tumor targeting potential a mannose-conjugated pH-sensitive nanosystem for effective delivery gefitinib (Gnb) lung cancers.
Previous studies have demonstrated that ovariectomy may lead to a reduction in antioxidative biomarkers the myocardium, thus suggesting estrogens serve protective role suppression of oxidative stress. Lycium barbarum polysaccharides (LBP) are well‑known antioxidant Chinese traditional medicine, which appear similar function with regards regulation cardiac function. In present study, 30 Sprague‑Dawley rats were randomly divided into following groups: Sham operation group, ovariectomized (OVX)...
Lathosterol oxidase (LSO) catalyzes the formation of C-5-C-6 double bond in synthesis various types sterols mammals, fungi, plants, and protozoa. In Leishmania parasites, mutations LSO or other sterol biosynthetic genes are associated with amphotericin B resistance. To investigate biological roles desaturation, we generated an LSO-null mutant line (lso- ) major, causative agent for cutaneous leishmaniasis. lso- parasites lacked ergostane-based commonly found wild-type L. major instead...
Sterol biosynthesis requires the oxidative removal of two methyl groups from C-4 position by sterol C-4-demethylase and one group C-14 C-14-demethylase. In
Non-small cell lung cancer (NSCLC) accounts for 80% of cancers. Cisplatin (DDP)-based combination chemotherapy is the main treatment NSCLC. Due to resistance DDP, 5-year overall survival rate NSCLC patients very low. Shenqifuzheng injection (SQFZ) essential progression. However, whether SQFZ plays a role in DDP and its molecular mechanism remains unclear.