A5101969455- Biofuel production and bioconversion
- Enzyme Catalysis and Immobilization
- Enzyme Production and Characterization
- Microbial Metabolic Engineering and Bioproduction
- Plant-Microbe Interactions and Immunity
- Proteins in Food Systems
- Plant Pathogenic Bacteria Studies
- Microbial Metabolites in Food Biotechnology
- Microencapsulation and Drying Processes
- Microbial Natural Products and Biosynthesis
- Food Chemistry and Fat Analysis
- Biochemical and biochemical processes
- Marine Sponges and Natural Products
- Plant tissue culture and regeneration
- Pharmacological Effects of Natural Compounds
- Plant Parasitism and Resistance
- Antioxidant Activity and Oxidative Stress
- Nematode management and characterization studies
- Protein Hydrolysis and Bioactive Peptides
- Food Quality and Safety Studies
- Studies on Chitinases and Chitosanases
- Genetics, Aging, and Longevity in Model Organisms
- Alkaloids: synthesis and pharmacology
- Phytochemical compounds biological activities
- Medicinal Plants and Neuroprotection
Nanchang University
2024-2025
Chinese PLA General Hospital
2025
Center for Excellence in Molecular Plant Sciences
2013-2024
Chinese Academy of Sciences
2017-2024
Jiangnan University
2012-2023
Shandong Academy of Sciences
2019-2023
Qilu University of Technology
2019-2023
State Key Laboratory of Food Science and Technology
2021-2023
Ghent University
2023
Jiangxi Academy of Forestry
2022
Plant immunity is activated upon pathogen perception and often affects growth yield when it constitutively active. How plants fine-tune immune homeostasis in their natural habitats remains elusive. Here, we discover a conserved suppression network cereals that orchestrates homeostasis, centering on Ca2+-sensor, RESISTANCE OF RICE TO DISEASES1 (ROD1). ROD1 promotes reactive oxygen species (ROS) scavenging by stimulating catalase activity, its protein stability regulated ubiquitination....
Lipids and lipid metabolites play important roles in plant-microbe interactions. Despite the extensive studies of lipases homeostasis seed oil biosynthesis, involvement plant immunity remains largely unknown. In particular, GDSL esterases/lipases, characterized by conserved motif, are a subfamily lipolytic enzymes with broad substrate specificity. Here, we functionally identified two lipases, OsGLIP1 OsGLIP2, rice immune responses. Expression OsGLIP2 was suppressed pathogen infection...
The filamentous fungus Penicillium oxalicum is a potential alternative to Trichoderma reesei for industrial production of complete cellulolytic enzyme system bio-refinery. Comparative omics approaches can support rational genetic engineering and/or breeding fungi with improved cellulase capacity. In this study, comparative genomic, transcriptomic and secretomic profiling P. HP7-1 its xylanase hyper-producing mutant EU2106 were employed screen novel regulators gene expression.The 30.62 Mb...
The calcium (Ca
The osteogenic differentiation ability of bone marrow mesenchymal stem cells (BMSCs) is an important aspect studying osteoporosis (OP). This study aims to explore the role SYVN1 in regulating BMSCs and suggest its potential as a treatment for OP. were differentiated using induction. expression at different induction time points was analyzed by Western blot (WB). levels markers, including RUNX2, ALP, OCN, measured RT-qPCR. EdU staining colony formation assays performed evaluate impact on...
A mesophilic xylanase from Aspergillus oryzae CICC40186 (abbreviated to AoXyn11A) belongs glycoside hydrolase family 11. The thermostability of AoXyn11A was significantly improved by substituting its N-terminus with the corresponding region a hyperthermostable 11 xylanase, EvXyn11(TS) . suitable be replaced selected comparison B-factors between and , which were generated calculated after 15 ns molecular dynamic (MD) simulation process. Then, predicted hybrid (designated AEx11A) modeled,...
The interaction of protein carrier and polyphenol is variable due to their environmental sensitivity. In this study, the between resveratrol whey isolate (WPI), sodium caseinate (SC) soy (SPI) during storage were systematically investigated from aspects loading, antioxidant activity oxidability. It was revealed that loaded more in SPI core existed both SC micelles on particle surface, while WPI mainly formed complexes. loading capacity three proteins ranked order > WPI. ABTS assay showed...
The contribution of disulfide bridges to the thermostability a type A feruloyl esterase (AuFaeA) from Aspergillus usamii E001 was studied by introducing an extra bridge or eliminating native one enzyme. MODIP and DbD, two computational tools that can predict possible in proteins for improvement, molecular dynamics (MD) simulations were used design bridge. One residue pair A126-N152 chosen, respective amino acid residues mutated cysteine. wild-type AuFaeA its variants expressed Pichia...
The AuMan5A, an acidophilic glycoside hydrolase (GH) family 5 β-mannanase derived from Aspergillus usamii YL-01-78, consists of only catalytic domain (CD). To perfect enzymatic properties the a 1 carbohydrate-binding module (CBM) Trichoderma reesei cellobiohydrolase I (TrCBH I), having lowest binding free energy with cellobiose, was selected by in silico design, and fused into its C-terminus forming fusion β-mannanase, designated as AuMan5A-CBM. Then, encoding gene, Auman5A-cbm, constructed...
Breeding for disease resistance is the most effective strategy to control diseases, particularly with broad-spectrum in many crops. However, knowledge on genes and mechanism of trade-off between defence growth crops limited. Here, we show that rice copine OsBON1 OsBON3 are critical suppressors immunity. Both changed their protein subcellular localization upon pathogen challenge. Knockdown dominant negative mutant each enhanced bacterial fungal pathogens either hemibiotrophic or necrotrophic...
Xylanases have attracted much attention owing to their potential applications. The applicability of xylanases, however, was bottlenecked by low stabilities at high temperature or extreme pH. purpose this work enhance the thermostability a mesophilic xylanase N-terminal replacement.The AoXyn11, family 11 from Aspergillus oryzae, enhanced replacing its segment with corresponding one EvXyn11(TS) , hyperthermotolerant xylanase. A hybrid thermostability, NhXyn11⁵⁷, predicted molecular dynamics...