This paper explores the task of real-time identification dynamic events leading to a layer situational awareness that can become reality due increased penetration phasor measurement units in transmission systems. Two underlying models for this task-data driven and physics based-are explored with examples. Challenges, advantages, drawbacks each model are discussed based on availability data, attributes such processing options. Potential applications improve security power system protection...

Extraskeletal osteosarcoma (ESOS) is a very rare malignant tumor. This study aimed to provide more evidence about the natural history and clinical features of ESOS, clarify impact chemotherapy (CT) radiotherapy (RT) on patient survival postoperative recurrence for sake gaining better understanding disease. Patient/tumor characteristics, recurrence, treatment, follow-up durations were collected by searching studies in PubMed, Web Science, Ovid, Elsevier, SpringerLink, Chinese National...

Shuxuening injection (SXNI) is a widely prescribed herbal medicine of Ginkgo biloba extract (EGB) for cerebral and cardiovascular diseases in China. However, its curative effects on ischemic stroke heart the underlying mechanisms remain unknown. Taking an integrated approach RNA-seq network pharmacology analysis, we compared transcriptome profiles brain ischemia reperfusion injury C57BL/6J mice to identify common differential target genes by SXNI. Models myocardial (MIRI) ligating left...

We performed three sets of experiments to investigate the safety intrathecal magnesium and determine its optimal dose for protection, if any, against ischemic spinal cord injury in rabbits. First, we examined neurotoxicity 0.3, 1, 2, or 3 mg/kg sulfate (n = 6 each). Significant sensory dysfunction was observed 3-mg/kg group 7 days after administration. Motor found two rabbits both 2- groups. The area destruction laminae V-VII one, two, one rabbit 1-, 2-, groups, respectively. Second,...

Involvement of adenosine and triphosphate-sensitive potassium (K ATP ) channels in the development ischemic tolerance has been suggested global ischemia, but not studied extensively focal cerebral ischemia. This study evaluated modulating effects A 1 receptor antagonist DPCPX (8-cyclopentyl-1,3-dipropylxanthine) mitochondrial K channel blocker 5HD (5-hydroxydecanoate) on to ischemia rats. Preconditioning with 30-minute middle artery occlusion (MCAO) reduced cortical subcortical infarct...

Glutamate is an excitatory neurotransmitter involved in neural function. Excess accumulation of intercellular glutamate leads to increasing concentration reactive oxygen species (ROS) and nitrogen (RNS) neuronal cells. In this study, we investigated the antioxidant activity several typical superior compounds among four cells, determined scavenging free radicals. The vivo assay was also carried out compare protective effect glutamate-induced cell damage. Hierarchical clustering analysis used...

Summary Aims Stroke is a leading cause of disability. However, there no pharmacological therapy available for promoting recovery. Although treatment stroke with cystamine has gained increasing interest, the detailed mechanisms underlying this process remain elusive. Thus, our aim to examine effect on function recovery after and investigate further mechanisms. Methods Adult male C57BL/6J mice were subjected photothrombotic model focal or sham operation. Cystamine saline was administered...

Febrile seizures (FS) are the most common type of for children. As a commonly used representative cold formula resuscitation, Zixue Powder (ZP) has shown great efficacy treatment FS in clinic, while its active ingredients and underlying mechanism remain largely unclear. This study aimed to preliminarily elucidate material basis ZP potential through ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS), network pharmacology, molecular...

PURPOSE: This study was conducted to investigate the effect of normal mesenteric lymph (NML) from mice on spleen injury induced by lipopolysaccharide (LPS) challenge. METHODS: Mice in LPS and LPS+NML groups received an intraperitoneal injection (35 mg/kg) kept for 6 h.. The group NML treatment at 1 h after injection. Afterward, splenic morphology, levels lipopolysaccharide-binding protein (LBP), cluster differentiation 14 (CD14), phosphorylation mitogen-activated kinases (MAPKs),...

As the representatives of closely related Chinese medicinal materials (CMMs) originated from Rutaceae family, Aurantii fructus immaturus (AFI), (AF), Citri reticulatae pericarpium viride (CRPV), and (CRP) have better functions in regulating qi promoting gastrointestinal motility. However, differences quality Citrus CMMs not yet been revealed until now. Herein, this study focused on systematic differentiation in-depth understanding by a strategy integrating chemometrics network pharmacology....

As a representative fermented Chinese medicine, Massa Medicata Fermentata (MMF) has been widely used for treating gastrointestinal diseases. Active amino acids are responsible disease treatment. However, the transformation pattern from proteins as primary ingredients to not fully unveiled during fermentation. Also, variation rule clarified processing. In this study, potential capacity in diseases predicated by network pharmacology analysis, were derived phenyl isothiocyanate and analyzed...

As a clinically effective traditional Chinese medicine injection (TCMI), Shuanghuanglian (SHLI) is widely used in the treatment of upper respiratory tract infection and pneumonia. However, shortage quality analysis limitation that remains to be improved clinical application SHLI. In this study, taking advantage ultra-high-performance liquid chromatography tandem Q-Exactive Orbitrap high-resolution mass spectrometry (UHPLC/Q-Orbitrap-MS), 31 chemical components (eight organic acids, eleven...

Qufeng Zhitong capsule (QZC) is a well-known Chinese patent medicine that has been widely applied for the clinical treatment of rheumatoid arthritis and other inflammatory diseases. To date, its material basis still unclear, which greatly limited application. In this study, by taking advantage ultra-high-performance liquid chromatography tandem Q-Exactive Orbitrap high-resolution mass spectrometry, 16 chemical components such as gallic acid, protocatechuic neochlorogenic acid in QZC were...

Qufeng Zhitong capsule (QZC), a Chinese patent medicine officially approved in China for the treatment of rheumatoid arthritis (RA) and other diseases, possesses primary effects dispelling wind, relieving pain, promoting blood circulation, whose clinical applications have been confined owing to incomplete elucidation its chemical compositions underlying molecular mechanism RA. In this study, 61 compounds including 16 phenylpropanoids, 15 organic acids, 13 alkaloids, seven flavonoids, six...

ObjectiveFibulin-1 is a matricellular protein that plays important roles in motility inhibition variety of cells and blocks the proliferation cultured neural stem cells. The biological function fibulin-1 spinal cord has not been fully elucidated.MethodsTo clarify expressions possible functions injury (SCI), we performed an acute contusion model adult rats. Our work studied temporospatial expression patterns fibulin-1.ResultsWestern blot analysis revealed levels significantly increased 5 days...