A5054506603- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Pharmacological Effects of Natural Compounds
- Natural Compounds in Disease Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Heavy Metal Exposure and Toxicity
- Plant-based Medicinal Research
- Edible Oils Quality and Analysis
- Aluminum toxicity and tolerance in plants and animals
- Ginkgo biloba and Cashew Applications
- CRISPR and Genetic Engineering
- Cholesterol and Lipid Metabolism
- RNA and protein synthesis mechanisms
- Gout, Hyperuricemia, Uric Acid
- Ferroptosis and cancer prognosis
- T-cell and B-cell Immunology
- Alzheimer's disease research and treatments
- Advanced Chemical Sensor Technologies
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Pesticide Exposure and Toxicity
- Behavioral Health and Interventions
- Spectroscopy and Chemometric Analyses
First Affiliated Hospital of Henan University
2021-2025
Huazhong University of Science and Technology
2021-2024
Weihai Municipal Hospital
2022-2024
Shandong University
2024
Sichuan Agricultural University
2024
Ministry of Ecology and Environment
2023
Tianjin University of Traditional Chinese Medicine
2023
Qilu Hospital of Shandong University
2023
Qingdao University
2016-2022
Chongqing Public Health Medical Center
2022
The authors have each completed and submitted an ICMJE form for disclosure of potential conflicts interest. declare that they no competing interests, financial or otherwise, related to the current work. All report since initial planning work, this study was funded by Chongqing Natural Science Foundation (Chongqing Technology Development Foundation) (No. CSTB2024NSCQ-KJFZMSX0027).
Abstract Background Obesity is rapidly globally increasing. Meanwhile, there an increase in negative perception of the body image and, consequently, weight control management. Body plays important mediating role between overweight or obesity and behaviours. This study aims to examine whether associated with dietary management behaviours among Chinese children adolescents. Methods Child health from Health Nutrition Survey (2015) were assessed, 729 boys 640 girls who aged 6 17 years included...
Lonicera japonica flos (LJF) is a common clinical herb with outstanding medicinal and nutritional value. This study aimed to evaluate the antidepressant effects of LJF's active extract compound chlorogenic acid (CGA) around BDNF-TrkB pathway. The results showed that LJF extracts CGA had significant effects, different was highly positively correlated content (FST, r = 0.998; TST, 0.934). Moreover, LJF-70% ethanolic improved CUMS induced depressive behavior, upregulated protein expression...
Febrile seizures (FS) are the most common type of for children. As a commonly used representative cold formula resuscitation, Zixue Powder (ZP) has shown great efficacy treatment FS in clinic, while its active ingredients and underlying mechanism remain largely unclear. This study aimed to preliminarily elucidate material basis ZP potential through ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS), network pharmacology, molecular...
Alzheimer’s disease (AD) is a neurodegenerative and threatens the health of aged population worldwide. In present study, we investigated cognitive improvement by aloe emodin in aluminum‐induced AD rats. We orally administered aluminum chloride (150 mg/kg) to Sprague–Dawley rats for 8 weeks induce AD. 5th 8th week, were injected intraperitoneally with AE (5, 10, 15 mg/kg). Behavioral, histopathological, biochemical assessments performed. The results showed that alleviated impairment inhibited...
Abstract Xenotransplantation, specifically the use of porcine organs for human transplantation, has long been sought after as an alternative patients suffering from organ failure. However, clinical application this approach impeded by two main hurdles: 1) risk transmission endogenous retroviruses (PERVs) and 2) molecular incompatibilities between donor pigs humans which culminate in rejection graft. We previously demonstrated that all 25 copies PERV elements pig genome could be inactivated...
Abstract Aims Corni Fructus (CF) and some CF‐contained prescriptions are commonly used in clinical treatment of depression. This investigation aims to evaluate the main active compound CF antidepressant properties its key target. Methods Firstly, this study established a behavioral despair model high‐performance liquid chromatography method antidepressant‐like effects water extract, 20%, 50%, 80% ethanol extracts CF, compound. Then, created chronic unpredictable mild stress (CUMS) assess...
This aim of the present study was to observe effect high mobility group AT‑hook 2 (HMGA2) on proliferation and invasion ability ACHN renal cell carcinoma (RCC) cells. Human cells, an RCC line, HKC normal human tubular epithelial cells were cultured. HMGA2 small interfering (si)RNA, Mock‑siRNA their negative control designed synthesized. Subsequently, transiently transfected using RNA interference technology. Finally, mRNA protein expression levels detected reverse transcription-polymerase...