A5102065364- Asthma and respiratory diseases
- Tribology and Wear Analysis
- Neonatal Respiratory Health Research
- Metal and Thin Film Mechanics
- Allergic Rhinitis and Sensitization
- Privacy, Security, and Data Protection
- Ginseng Biological Effects and Applications
- Pneumonia and Respiratory Infections
- Mechanical stress and fatigue analysis
- IL-33, ST2, and ILC Pathways
- Labor market dynamics and wage inequality
- Microbial Metabolic Engineering and Bioproduction
- Probiotics and Fermented Foods
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Endoplasmic Reticulum Stress and Disease
- Respiratory and Cough-Related Research
- Muscle and Compartmental Disorders
- Immune Cell Function and Interaction
- Genomics, phytochemicals, and oxidative stress
- Bacterial Genetics and Biotechnology
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Transplantation: Methods and Outcomes
- Innovative Human-Technology Interaction
- Aluminum toxicity and tolerance in plants and animals
Northeastern University
2023-2024
Shanghai Jiao Tong University
2024
Tsinghua University
2024
Southwest Jiaotong University
2022-2023
First Hospital of Jilin University
2013-2022
Jilin University
2013-2022
University of Jinan
2020
Jilin Medical University
2015-2018
This study investigated the frequency and absolute numbers of different subsets peripheral blood cells, including CD4+ T cells CD19+ interleukin (IL) 10+ B regulatory (Breg) their potential association with clinical laboratory measurements in children diagnosed simple asthma or plus allergic rhinitis (AR).The interferon (IFN) gamma+ T-helper (Th) type 1, IL-4+ Th2, IL-17A+ Th17, CD4+CD25+ Forkhead Box P3+ (Treg) IL-10+ Bregs 22 asthma, 17 AR, 25 healthy controls were determined by flow...
The function and mechanism underlying the suppression of human osteosarcoma cells by ginsenoside-Rg5 (Rg5) was investigated in present study. MG-63, HOS, U2OS cell proliferation determined MTT assay after Rg5 treatment for 24 h. inhibited effectively a dose-dependent manner. range effective inhibitory concentrations 160-1280 nM. Annexin V-FITC PI double-staining revealed that induced apoptosis. Western blotting, qRT-PCR, FACS experiments via caspase-3 activity which related to LC3-mediated...
Low Clostridium leptum levels are a risk factor for the development of asthma. C. deficiency exacerbates asthma; however, impact early-life exposure on cesarean-delivered mice remains unclear. This study is to determine effects asthma in infant mice.We exposed (fed-CL) and then induced using allergen ovalbumin (OVA).Fed-CL increased regulatory T (Treg) cells compared with vaginally delivered mice. Compared OVA-exposed mice, + OVA did not develop typical phenotype, which includes airway...
Alzheimer’s disease (AD) is a neurodegenerative and threatens the health of aged population worldwide. In present study, we investigated cognitive improvement by aloe emodin in aluminum‐induced AD rats. We orally administered aluminum chloride (150 mg/kg) to Sprague–Dawley rats for 8 weeks induce AD. 5th 8th week, were injected intraperitoneally with AE (5, 10, 15 mg/kg). Behavioral, histopathological, biochemical assessments performed. The results showed that alleviated impairment inhibited...
Elevated lactate concentrations are implicated in various acute and chronic diseases, such as sepsis mitochondrial dysfunction, respectively. Conversely, ineffective clearance is associated with poor clinical prognoses high mortality these diseases. While several groups have proposed using small molecule inhibitors enzyme replacement to reduce circulating lactate, there few practical effective ways manage this condition. Recent evidence suggests that exchanged between the systemic...
Oxidative stress or the production of reactive oxygen species (ROS) has been implicated as an important factor in development bleomycin (BLM)-induced pulmonary toxicity; however, mechanism behind toxicity remains to be elucidated. The present study aimed investigate key involved BLM‑induced toxicity. was conducted human fibroblast (HPF) cells and a mouse model. ROS level, cell death assay, protein gene expression levels Kruppel‑like 9 (Klf9) other associated factors were assessed. A...
Elevated lactate concentrations are implicated in various acute and chronic diseases such as sepsis mitochondrial dysfunction, respectively. Conversely, ineffective clearance is associated with poor clinical prognoses high mortality these diseases. While several groups have proposed using small molecule inhibitors enzyme replacement to reduce circulating lactate, there few practical effective ways manage this condition. Recent evidence suggests that exchanged between systemic circulation the...
Purpose: Bronchiolitis obliterans (BO) is a highly debilitative and fatal syndrome associated with series of severe lower airway disorders. The pathogenesis BO complicated not entirely understood. An appropriate animal model may aid research into its pathogenesis. Here, we establish mouse to provide insight this disease. Materials Methods: 6–8 week old BABL/c mice were exposed 5% nitric acid (NA) aerosol through nebulizer for 3 hours, controls distilled water instead. Symptoms, resistance...
Bronchiolitis is the most common lower respiratory infectious disease in infants presenting with cough and/or wheeze and occurs frequently winter months. Treatment of bronchiolitis by means nebulization inhaled corticosteroids bronchodilator such as salbutamol or ipratropium bromide considered an effective method. Usually, 0.9% normal saline used together medications mentioned above. However, there are studies showing that 3% hypertonic might be a better choice compared saline. Objective:...
Objective To investigate the effects of exposure to cigarette smoke on counts and functions tolerogenic dendritic cells(tDC) regulatory T cells(Treg) in a mouse model asthma. Methods Forty female BALB/c mice at age 20 days were randomly allocated into four groups including normal saline (NS)/air treatment group, NS/cigarette (CS) ovalbumin (OVA)/air group OVA/CS (n=10). A asthma was established by intraperitoneally injecting OVA an interval two weeks for three weeks. The percentages...
Home cameras can detect emergencies of older adults and send timely life-saving alerts, such as fall detection. However, also pose a threat to privacy, there are still controversies about how protect adults’ privacy while supporting live at home. In this study, we assessed attitudes toward the issue home using surveys (N=389) interviews (N=20). Furthermore, conducted co-design workshop (N=6) in which designers collaborated develop camera appearance prototype. We found that for adults,...
Abstract The synergy of tribology design and surface engineering is vitally important for fulfilling the long-term anti-wear requirements mechanical equipment. Here, Q345 steel was processed by shot peening (SP) forming a volcano-like hardened layer (77.72 HV) with high roughness (3.77 μ m) low residual tensile stress (210.75 MPa). Then, zinc-rich epoxy coating painted on SP-strengthened to construct double-layer protection. system shows excellent tribological behaviors, especially wear...
Epilepsy is a group of chronic brain diseases characterized by transient central nervous system dysfunction caused repeated abnormal synchronization neuronal discharges in the brain, with sudden onset and seizures. has been listed as one five major neuropsychiatric World Health Organization (WHO). Hereditary epilepsy refers to syndromes previously classified idiopathic generalized epilepsies (IGEs), which encompasses several different ranging clinical severity from relatively benign febrile...