A5100406757- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Acute Kidney Injury Research
- Hemoglobin structure and function
- Immune Response and Inflammation
- Drug-Induced Hepatotoxicity and Protection
- Vagus Nerve Stimulation Research
- Pancreatic function and diabetes
- Early Childhood Education and Development
- Anesthesia and Pain Management
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Dietary Effects on Health
- Tryptophan and brain disorders
- Nausea and vomiting management
- Abdominal Trauma and Injuries
- Lipid metabolism and disorders
- Pain Mechanisms and Treatments
- Esophageal and GI Pathology
- Inflammatory mediators and NSAID effects
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Synthesis of Organic Compounds
- Renin-Angiotensin System Studies
- Fatty Acid Research and Health
- Nitric Oxide and Endothelin Effects
- Aldose Reductase and Taurine
Beijing Tian Tan Hospital
2017-2025
Capital Medical University
2017-2025
HKUST Shenzhen Research Institute
2025
Hong Kong University of Science and Technology
2025
University of Hong Kong
2025
Hebei Medical University
2021-2023
Guangzhou University
2020-2023
Huashan Hospital
2023
Fudan University
2023
Weifang People's Hospital
2015-2023
The dynamic erosion effect of the corrosive medium formed by aqueous solution and CO2 gas on rock will lead to decline mechanical properties seriously threaten long-term stability durability mass in reservoir area. In this paper, a test method is proposed study deterioration rock, based gas–liquid cycle. A total 210 limestone samples were tested under various cycles (0, 5, 10, 15, 20, 25, 30 cycles). systematic analysis key physical related degradation behavior (Young's modulus, uniaxial...
For participants with intracranial aneurysm who underwent stent treatment, light transmission aggregation–guided antiplatelet therapy helped reduce ischemic events without increasing bleeding risks.
Objectives: Abnormal rheological properties induce adverse effects during sepsis. This study sought to investigate the hypothesis that resveratrol (Res) improves blood in rats following a lipopolysaccharide (LPS) challenge, and provide novel approach for treatment of Methods: The were intraperitoneally or intramuscularly injected with vehicle, LPS (8 mg/kg), Res (30 both yield four groups: control, Res, LPS, + Res. After 6 h and/or injection, mean arterial pressure (MAP), regional flow,...
This study tested the potential mediating roles of various cognitive abilities in middle childhood (i.e., short-term memory [STM], sustained attention, and inhibitory control) associations between home learning environment early child adjustment multiple domains during adolescence internalizing externalizing problems, language skills, social competence), based on data from National Institute Child Health Human Development Study Early Care Youth (N = 1,364). Results demonstrated that quality...
Background Many studies have revealed that transforming growth factor‐beta ( TGF ‐β) signals play important roles in maintaining normal status of articular cartilage human osteoarthritis OA ). However, SMAD 3 had inhibitory effect on ‐β‐induced chondrocyte maturation. Method To evaluate the association genetic variants with risk knee , we conducted this hospital‐based case‐control study involving 350 patients and 400 controls a Chinese population. Genotyping was performed using...
Lymphatic reactivity has been shown to exhibit a biphasic change following hemorrhagic shock, and nitric oxide (NO) is involved in this process. However, the precise mechanism responsible for NO regulation of lymphatic along with progression shock unclear. Therefore, present study was investigate how participates regulating shock-induced changes its underlying mechanisms. First, expressions or contents inducible synthase, nitrite plus nitrate, elements cAMP-PKA-KATP cGMP-PKG-KATP pathway...
Vascular hypo-reactivity plays a critical role inducing organ injury during hemorrhagic shock. 17β-estradiol (E2) can induce vasodilation to increase blood flow in various vascular beds. This study observed whether E2 restore induced by shock, and effects are associated with RhoA-Rho kinase (ROCK)-myosin light chain phosphatase (MLCP) pathway. The shock model (40 ± 2 mm Hg for 1 h, resuscitation 4 h) was established ovary intact sham operation (OVI), ovariectomized (OVX), OVX plus supplement...
Kidney injury commonly occurs after hemorrhagic shock. Previous studies have shown that post–hemorrhagic shock mesenteric lymph (PHSML) return negatively affects the kidneys and may induce injury. This study investigates effect of PHSML drainage on proteome in renal tissue. A controlled model was established shock+drainage groups. After 1 h hypotension, fluid resuscitation implemented within 30 min. Meanwhile, drained group. 3 resuscitation, tissue extracted for analysis using...
This study aimed to investigate the effect of mesenteric lymph drainage on acute kidney injury induced by hemorrhagic shock without resuscitation. Eighteen male Wistar rats were randomly divided into sham, shock, and groups. The model (40 mmHg, 3 h) was established in groups; performed from 1 h hypotension group. results showed that renal tissue damage occurred; levels urea, creatinine, trypsin plasma as well intercellular adhesion molecule-1 (ICAM-1), receptor advanced glycation...
Background: Kidney injury commonly occurs following hemorrhagic shock. This study aims to observe the effects of mesenteric lymph duct ligation (MLDL) on adenosine triphosphate (ATP) levels and cell membrane triphosphatase (ATPase) activity in kidneys rats subjected Methods: Wistar were assigned into sham, shock, groups. The shock model was established groups, MLDL performed group after resuscitation. Renal homogenates prepared determine ATP ATPase at 90 min hemorrhage 0, 1, 3, 6, 12, 24 h...
PURPOSE: This study was conducted to investigate the effect of normal mesenteric lymph (NML) from mice on spleen injury induced by lipopolysaccharide (LPS) challenge. METHODS: Mice in LPS and LPS+NML groups received an intraperitoneal injection (35 mg/kg) kept for 6 h.. The group NML treatment at 1 h after injection. Afterward, splenic morphology, levels lipopolysaccharide-binding protein (LBP), cluster differentiation 14 (CD14), phosphorylation mitogen-activated kinases (MAPKs),...
To investigate the effect of mesenteric lymph drainage on spleen injury and expressions inflammatory cytokines in splenic tissue mice following hemorrhagic shock.Male C57 were randomly divided into sham shock, shock shock+drainage groups. The both groups suffered femoral artery bleeding, maintained mean arterial pressure (MAP) 40±2 mmHg for 90 min, resuscitated. And was performed group at time resuscitation. After three hours resuscitation, tissues harvested histological observation protein...
Vascular endothelial injury caused by post-hemorrhagic shock mesenteric lymph (PHSML) return is an important manifestation during refractory hemorrhagic shock. By using human umbilical vein cells (HUVECs) and transcriptome analysis, the present study sought to investigate molecular mechanism underlying adverse effect of PHSML on vascular endothelium. was collected from male rats underwent following resuscitation, while normal (NML) harvested sham rats. HUVECs were incubated with culture...